Manic Depressive Treatments Essay

Aretaeus of Cappadocia began the process of detailing symptoms in the medical field in the early 1st century in Greece. The ancient Greeks and Romans were responsible for the terms “mania” and “melancholia” now known as manic and depression. In 1970, lithium is approved to treat mania. In 1980, bipolar disorder replaces manic-depressive disorder.

There is more to the treatment of bipolar disorder than medication, but the medication Lithium has been the primary treatment since the 1960’s. In four studies

(392) Before answering the question let’s figure out what lithium is. We know it is a drug to treat bipolar disorders, but it is a silvery white element found throughout the world in various simple mineral salts (Comer, 2013, pp.280). Individuals who take lithium suffer from bipolar disorders

Bipolar Disorder The aspect of bipolar disorder has been a mystery since the 16th century. It was rumored that Vincent Van Gough suffered from bipolar disorder. There is a large group of people suffering from this disorder, however there are no causes or cures for it. Bipolar disorder impairs one’s ability to obtain and sustain social and occupational success. The journey for even a cause will continue for many years to come.

Bipolar disorder is characterized by unusual and sudden changes in mood, energy, activity levels affecting the ability to perform everyday tasks, impacting negatively relationships, professional life and often leading to suicide. Bipolar disorder usually show signs in adolescence or early adulthood and is a long term condition that must be appropriately treated in order to improve the life quality of the patient. Often people suffering from bipolar disorder also suffer addiction to drugs and alcohol and one of the reasons is that people with bipolar disorder sometimes try to self treat their symptoms with alcohol and drugs, which make bipolar symptoms worse. The causes of bipolar disorder are unknown, however most scientist agree that a

According to the Centers for Disease Control and Prevention, 8% of persons over the age of twelve reports being currently depressed, this includes 6% of the male population (2014). This literature also reports males aged forty to fifty-nine having higher rates of depression (7%), when compared to males sixty years or older (5%) (2014). In 2010 there were 63.3 million visits to primary care physicians, hospital outpatient units and emergency rooms attributed to mental health diagnosis (CDC, 2014). In the same year, there were 395,000 psychiatric inpatient discharges with major depressive disorder as the primary diagnosis. These individuals had an average stay of six and a half days (CDC, 2014). Inpatient and outpatient treatment is seemingly a revolving door. One article examines the growing number of people being diagnosed with depression, yet the declining number of people seeking outpatient care. This article reports 2.88 out of 100 people seek outpatient treatment for their depression (ScienceDaily, 2010). It is imperative for practitioners of group practice to understand that men and women experience depression differently and to then formulate treatment based on the individual’s unique needs (NIH, 2014).

Jann States that sufferers of BPD are three times more likely to suffer a depressive episode than a manic or hypomanic episode. (Jann, 2014) The Joanna Briggs institute Identified that the suicide rate for bipolar suffers are 15 times higher than that of non-affected individuals of the same age and sex. Eighty percent of these suicides occur during a depressive episode. (Hung Chu, 2016). Therefore appropriate pharmacological therapy not only during the maintenance period to reduce reoccurrence but also during these acute episodes is highly important. Pharmaceutical treatment includes the use of medication such as mood stabilizers, anti-psychotics and anti-depressants. The Joanna Briggs institute recommends that combination therapy involving both mood stabilizers such as Sodium valproate or lithium valproate and antipsychotics risperidone, olanzapine, quetiapine and haloperidol is best to treat acute mania associated with Bipolar. As it increases adherence to medication regime. (Tufanaru, 2016) The same institute encourages the use Olanzapine as a monotherapy or in combination with fluoxetine in the treatment of Depression associated with Bipolar disorder. (Hung chu, 2016) Lithium continues to be the first line mood stabilizer under current guidelines but may be used in conjunction with Carbamazepine where depression is evident. (Hung chu, 2016) The Australian and New Zealand Journal of Psychiatry 2015 also shows preference for combination therapy

Antipsychotic drugs such lithium is one that is commonly prescribed to help reduce anger, threatening behavior, outbursts, and combativeness in ASPD. It alters sodium transport and inhibits neuronal signaling that dials down the activity of hyperactive circuits involved in producing mania (Vallerand, Sanoski, & Deglin, 2017). Lithium dosage is PO in tablets or capsules at 300-600mg TID for adults but precise dosing is based on serum lithium levels. Side effects include polyuria, polydipsia, diarrhea, mild ataxia, leukocytosis, renal toxicity, drowsiness, and weight gain.

Lithium Carbonate is also known as Lithobid or also Eskalith. When taking Lithium, it alters the sodium transport nerve and muscle cells. The alterations of the sodium transport in the two areas can cause the intraneuronal metabolism of catecholamines. When taking any medication,

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Lithium can inhibit thyroid function. Concomitant use with iodine may have additive or synergistic hypothyroid

There are not nearly as many treatments for bipolar disorder. In fact, there is only one treatment that seems to have lasting effects. This treatment uses therapy with a professional coupled with medications. “Antibipolar drugs, also called mood stabilizers, help steady the mood of those with a bipolar disorder” (Chapter 2, 2009). The advances in treatment are due to the discovery of lithium as a medication. This drug works extremely well to eliminate manic episodes and even help with the depression. The drugs

Lithium is a top choice for acute mania and for maintenance in ‘classic’ bipolar disorder. Because of its narrow therapeutic range, blood levels must be monitored; also heart and kidney function (EKG, blood and urine tests). Medications such as diuretics, that block its excretion require caution.