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Mechanical Hyperalgesia Case Study

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Figure 1. Enhanced mechanical hyperalgesia was persistent in CCI model until 56 days post-surgery (A). * denotes significant differences compared to naive (p ≤ .05 and .001) and # denotes significant differences compared to sham (p ≤ .01 and .001) using 2-way ANOVA and Bonferroni test. CCI showed higher mechanical hyperalgesia 56 days compared to 14 days post-surgery (B). * denotes significant differences compared to baseline (p ≤ .0001) and # denotes significant differences compared to CCI 14 days (p ≤ .0001) using 1-way ANOVA and Bonferroni test. Figure 2. Tactile threshold was decreased in CCI group compared to control groups over time (A). * denotes significant differences compared to naive (p ≤ .001) and # denotes significant differences compared to sham (p ≤ .001) using 2-way ANOVA and Bonferroni test. CCI showed higher tactile allodynia 28 days compared to 14 days post-surgery (B). * denotes…show more content…
Enhanced acetone response was changeable in CCI model over 56 days post-surgery (A). * denotes significant differences compared to naive (p ≤ .001) and # denotes significant differences compared to sham (p ≤ .001) using 2-way ANOVA and Bonferroni test. CCI showed a threefold increase in time reaction over 42 and 56 days compared to 14 and 28 days after surgery (B). * denotes significant differences compared to baseline (p ≤ .0001) and # denotes significant differences compared to CCI 14 and 28 days (p ≤ .0001) using 1-way ANOVA and Bonferroni test. Figure 4. Thermal threshold was decreased in CCI group compared to control groups over time (A). * denotes significant differences compared to naive (p ≤ .001) and # denotes significant differences compared to sham (p ≤ .05, .01 and .001) using 2-way ANOVA and Bonferroni test. CCI showed a constant thermal hyperalgesia threshold over time compared to baseline and no difference between CCI evaluations (B). * denotes significant differences compared to baseline (p ≤ .0001) using 1-way ANOVA and Bonferroni
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