Melanoma Skin Cancer Research Paper

These brown coloured cancerous growths develop when unrepaired DNA has committed damage to the body’s skin cells. It is known that it is the most commonly triggered by vigorous amounts of sunshine, over excessive use of tanning bed and UV lights which result in making mutations in the skin that produces the skin cells to over multiply at a quick rate which can eventually form nasty tumours.

Although there are several types of skin cancer, the most aggressive form is melanoma. This cancer of the skin involves mass replication of the pigment producing melanocyte cells, which are located in the epidermis, below the basal layer. There are several factors involved with the onset of melanoma including, exposure to ultraviolet rays, genetic predisposition, numerous nevi (moles), immunosuppression, and environmental exposure to carcinogens.

Melanoma is a dangerous invasive cancer which starts in melanin producing cells (melanocytes) usually located at the bottom of the skins epidermal layer. Although certain individuals have a genetic propensity for melanoma, it is usually triggered by excessive UV exposure from sunlight or tanning beds (Mayo Clinic, 2016a). At early stages it is relatively easy to treat, however, recurrences are common. At later stages melanoma treatments are less effective since it tends to metastasize and spread easily through the lymphatic system (Mayo Clinic, 2016a).. The root cause of malignant melanoma is due to mutations in the p53 gene protein which invariably leads to further mutations.

There are three primary layers of the skin: the outer layer, the epidermis and the layer beneath, the dermis and the hypodermis. The epidermis is thin, tough and waterproof while protecting the body from outside bacteria invading the body. It also contains keratinocytes which are from the basal layer which is the deepest layer of the skin. The keratinocytes reach up to the epidermis, shed and new ones form again. The dermis is the second layer of the skin and is the thickest. It is made from fibrous and elastic tissues which are made from fibrillin, elastin and collagen to create the strength and flexibility. It also contains sweat and oil glands, nerve endings, blood vessels and hair follicles. Sweat glands help the body cool off during heat

Melanoma is a malignant condition arising from melanocytes in the basal layer of the skin. Melanocytes are the cells that produce melanin, which gives skin its pigmentation and shields the deeper layers of skin from the damaging effects of ultraviolet radiation. When skin is exposed to ultraviolet radiation, melanocytes increase their production of melanin, which generates darker pigmentation of the skin. Ultraviolet radiation stimulates malignant changes within the melanocytes by mutating DNA, stimulating cutaneous growth factors, decreases immune defenses, and promotes species of melanin that cause DNA impairment and suppress apoptosis. The abnormalities caused by ultraviolet radiation in the melanocytes predispose it to

Melanoma can be anywhere on your body. Moles, warts, or even a sun burn can lead to melanoma. Melanoma is a form of cancer that begins in melanocytes, cells in the skin that produce the brown color known as melanin. These are the cells that darken when exposed to the sun, a protective response to protect the deeper layers of the skin from the harmful effects of the sun.

Malignant melanoma is the most commonly seen skin cancer and it has the highest number of deaths among diseases of the skin (Friedman, Rigel, Kopf and Polsky, 2005). Among the many factors that cause this cutaneous cancer genetic modifications, viruses, carcinogens and excessive exposure to ultraviolet rays are the most commonly occurring (Friedman, Rigel, Kopf and Polsky, 2005). Malignant melanoma affects all areas of the skin and the disease forms in melanocytes, which are the cells in which pigments (melanin) are synthesized (Melanoma Treatment). The cancer has its origin in the epidermis and affect squamous and basal cells. The disease usually affects the trunk, arms and legs but can also be present in the eye, affecting the

Malignant melanoma of the nail apparatus is extremely rare but there have been a few cases reported. It seems that almost half of the population that has been diagnosed with this disease has been misdiagnosed or did not receive the proper treatment to cure the disease. Since the cases are easily misdiagnosed, fatality is usually the outcome for most. Survival rate of this particular disease in recent studies has shown that humans live on average five years after being diagnosed with melanoma of the nail. The disease can affect either the upper or lower nail extremities. The scientist tested seven people, three males and four females, to see how this disease effects each of the patients.

There’s different type of cancers that affects the whole body, and in detail there’s different types of cancers on specific parts of the body. Malignant Melanoma is a form of skin cancer, the most aggressive form of skin cancer. Annually, Melanoma kills more than 10,000 people in the United States. More than 76,000 people are diagnosed every year with this disorder. Once Melanoma is spotted, it’s best to seek treatment, the earlier the better. This form of cancer can spread to other parts of the body if it’s not treated early, and it can become fatal. Moles, brown spots, and growth of either of these things is usually where Melanome can be found, for the most part it can be harmless. Although if you see a growth it’s best to contact your physician

Squamous Cell Carcinoma – Accounts for 20% of non-melanoma cancers and causes death in about 10% of affected patients.

Melanoma is a skin cancer that develops in pigment cells. These pigment cells are called melanocytes. These cells can grow rapidly and can spread throughout the lymphatic system. Early detection is a key factor when dealing with melanoma. The survival rate is determined by how early the cancer is diagnosed. If the cancer is caught at an early stage the survival rate is about 99%, but if it is not and it spreads throughout the lymphatic system, the survival rate drops to 14%. Melanoma is less common than most cancers but is one of the most dangerous cancers. Melanoma is caused by the exposure to ultraviolet from the sun and sunbeds. Sunburns that repeatedly occur can eventually cause the development of Melanoma. Melanoma can start off as just

In the scholarly article “Influencing melanoma prevention”, Calianno explained the significance of the growing amount of people that are being diagnosed with cancer (2011). The article states risk factors that are indicative of people more susceptible to getting cancer, but also how early detection can be categorized. These risk factors include genetic predisposition, skin type, environment…large congenital moles, or extensive freckles (Calianno, 2011, p. 6). There are four main types of melanoma included but the most common is

Cutaneous melanoma (hereafter referred as melanoma) is a worldwide public health concern. In developed countries melanoma ranks as the sixth most frequently diagnosed cancer overall [1]. In the United States, melanoma is the fifth most common cancer in men and seventh most common cancer in women [2]. The incidence of melanoma, the most commonly fatal form of skin cancer, is increasing faster than any other potentially preventable cancer in the United States [3-4]. World wide epidemiological data shows similar increases over the past years, with a leveling off in other countries [5]. Some researchers attribute the increase in the incidence of melanoma to a more scrutinized detection program [6-7].

In past years there has been a major reduction in the ozone layer, because of this the chance of skin cancers like melanoma have increased significantly. It is well known that ultraviolet radiation is a major factor in a person’s risk of being diagnosed with cutaneous melanoma because it is part of the radiation that actually touches Earth’s surface. It is also known that living closer to the equator increases a person’s chance of some type of skin cancer. But is it possible to break this down into even more information? Does sex, age, or socioeconomic status play any type of role in a person’s risk factor of melanoma? In the article, The Risk of Melanoma Associated with Ambient Summer Ultraviolet Radiation many scientists come together to

Thesis: Skin cancer is the most common type of cancer in the United States but is highly curable if detected early and treated properly.