Melasma Severity Index

Unlike other cancers which we can develop, melanoma can often be detected on the skin which allows doctors to treat it at its early stages resulting in less complications and lower death rates to patients, again if left undetected at its early stages this can easily spread to distant areas and distant organs. Once melanoma has spread to other areas of the body which is classified as stage IV it is diagnosed as

The submitted records have been reviewed. The member is an adult female with a birth date of 07/01/1987. She has a diagnosis of cutaneous melanoma. Her treating provider, Semyon Zarkhin, MD recommended DecisionDX Melanoma testing, which was performed on 11/23/2015.

Kristen, I found your posting very informative especially regarding the risk factors of the Hispanic community. One small observation that I noted is that there is no explanation as to what the MRAT acronym stands far. The Melanoma Risk Assessment Tool (MRAT) unfortunately is very limited in its usage because it is useful for non-Hispanic whites only missing a significant portion of our population.

Acral Lentiginous Melanoma or ALM is a rare subtype of melanoma that occurs more often in people of color. It accounts for 2 to 3 percent of the all of the world’s cases of melanoma (Bradford). Dr. R. J. Reed in 1976 was the first to describe it as the appearance of dark lesions on the hands and feet. Radial or lentiginous was the main phase of its growth that lasts several years then it changes into a vertical or dermal invasive stage (Bradford). Several universities have released results on tests on ALM but since it is rare it was difficult for the research groups to get solid information because of small sample sizes. Nonetheless, studies by scientists such as Dr. R. J. Reed we able to determine that the survival rate for three years with the melanoma was on average at 11% (Bradford).

Melanin is the pigment produced by melanocytes to give skin, hair and eyes their colour. When melanocytes are destroyed, skin cells appear white. In addition to giving skin its colour, melanin also protects our skin from the sun. Lack of melanin in the skin leads to a greater risk of sun burn in affected areas and the development of skin cancer

Once the melanoma’s type has been recognised the next step is to classify them based on their respective severity. This classification is known as the stage. Each stage defines how far the melanoma has penetrated inside the skin and the thickness of the malignant moles and the spreading of the disease. The stage is used to determine the kind of treatment used to diagnose the patient.

Melanoma is a serious type of skin cancer, causing up to 75% cancer-related deaths and is usually occurs due to exposure to UV rays of the sun. The chances are increased with sunburn episodes especially during childhood. It developed from the pigment cells known as melanocytes, a layer of cells producing melanin which protects against the damaging rays of the sun. Sometimes, these pigment cells increase in size and become cancerous melanoma. It didn’t show any particular symptoms, however, it is related to the changes associated with moles, gives ‘ABCDE’ warning signs i.e. Asymmetry, irregular Border, uneven Colour, Diameter, evolution.

Melorheostosis is a disease of the skeletal system and is a condition that begins mostly during childhood, or before the age of twenty. This disease is known for the thickening of the bones, in which the outer layer of the bone widens and becomes hyperdense in a sclerotomal distribution. This condition often times only affects the appendicular skeleton and is known as a mesenchymal dysplasia. Melorheostosis is very rare and is non hereditary. This disease has a “flowing wax” appearance that makes it very recognizable when examining the bones.

Malignant melanoma of the nail apparatus is extremely rare but there have been a few cases reported. It seems that almost half of the population that has been diagnosed with this disease has been misdiagnosed or did not receive the proper treatment to cure the disease. Since the cases are easily misdiagnosed, fatality is usually the outcome for most. Survival rate of this particular disease in recent studies has shown that humans live on average five years after being diagnosed with melanoma of the nail. The disease can affect either the upper or lower nail extremities. The scientist tested seven people, three males and four females, to see how this disease effects each of the patients.

The care of patients who have cutaneous melanoma (CM) has undergone a dramatic shift during the past 5 decades. Excision of pre-metastatic; CM has been the overriding goal. because once distant metastases have occurred. prognosis is dismal. Skin awareness and self-examination by patients. screening examinations of the skin, nails, and mucous membranes by physicians, and careful long-term Surveillance of patients determined in be al high risk for CM 'based on identifiable historic and phenotypic traits are having an immediate positive impact on CM. related mortality and CM-related case. fatality rate.

Although uveal melanoma is a rare malignancy, it is the most common primary intraocular tumor in adults (Kashyap, 2016) and occurs at a rate of 5.1 per million per year (Kaliki, 2016). Uveal melanoma may develop anywhere within the uveal tract, however it most commonly arises in the choroid (90%), followed by the ciliary body (6%) and then the iris (4%) (Kaliki, 2016). The at-risk population includes those with light skin, light eyes, ocular melanocytosis, nevi of the iris or choroid and the BRCA1-associated protein mutation (Kaliki, 2016). Uveal melanoma has been found to be most common in the middle-aged Caucasian population with a median age of 62 years old at presentation and with a 30% higher incidence among males relative to females

Melanoma being the austere form of skin cancer which can be fatal in most cases. Mayo Clinic’s article on the diseases and conditions of melanoma gives good clarity as to what is actually occurring, and how it forms. The article states that what causes melanoma is unclear and hasn’t been discovered but what takes place is the melanocytes that generate melanin cells is agitated by unknown causes which results in the change in pigmentation of the skin or a change in a current mole already present on the skin. Strategies that can help you detect the symptoms of melanoma consist of the letters “A- E meaning A: asymmetrical shape regarding moles, B: irregular boarders, C: change in color, D: diameter, and E: evolving” (Mayo Clinic Staff 2016) Melanoma can appear not only on the skin but underneath a person’s nail, it can affect their eyesight and rarely their internal organs such as the mouth, urinary tract, and digestive tract called mucosal melanoma. These are noted to be hidden

Cancer occurs when cells in the human body create irregularities and start to duplicate at anomalous quick rates. The outcome is the development of tumors in or on the surface of the body and organs. Tumors might be generous (not destructive) or threatening (harmful). Since ordinary cell improvement and duplication is a moderate procedure which is well controlled, it is evident when cells duplicate so rapidly.

The aim of this essay is to explore the objectives, the hypotheses, the study design, the research methods, statistical data analysis, the results and the ensuing discussion in the research paper mentioned above and try attempt analyze why, contrary to expectations, this study did not find a significant efficacy of MTX in dcSSc despite having documented efficacy in skin scores. Systemic sclerosis (SSc) is a chronic, rare, complex, multisystem, autoimmune disease of the connective tissues with diverse variants. Progressively the skin thickens and scars, with excessive accumulation of fibers, cells and collagen in the skin and visceral organs,

Melasma is a skin disorder that appears as irregular brown skin patches on the cheeks, nose, forehead and upper lip. Melasma is not dangerous, but can impair your appearance, personality and self confidence. Various options of treatment are available and dermatologists found the melasma laser treatment to be effective of all.