Memory Formation And Its Effects On The Nervous System

Among these different processes are encoding, storage, consolidation, and retrieval. This study hypothesized that the hippocampus plays a different role in each of these. The method of this study is especially unique because it used temporary chemical inactivation of the hippocampus, which had not been done before. This temporary inactivation is unique because it lets the researchers selectively assess the role of the hippocampus during each of the processes discussed above. To test encoding, the inactivation occurred during learning of a maze task; to test retrieval, inactivation occurred during a retention task. Results indicate the temporary inactivation of the hippocampus impairs both encoding and retrieval. To test long-term consolidation, rats were trained and then separate groups received hippocampal treatment for different amounts of time between one and five days. Results showed that temporary inactivation during this time period disrupts memory for the already learned task. This study partially supports the result of the study by Eldridge et al. (2000) in that they both show the hippocampus is necessary for memory retrieval. However, it does not address the retrieval of different types of memory. This study also supports the idea from Wang et al. (2012) that the hippocampus may be involved in consolidation and storage of new memories but not necessarily of older

Research has shown that there is “greater activation in the left inferior frontal and medial temporal lobes” (Stanford, 2006, p. 208) during the encoding of words which were later remembered as compared to those which were forgotten. The sensations perceived by sensory nerves are decoded in the hippocampus of the brain into a single experience (Mastin, 2010). The hippocampus analyses new information and compares and asssociates it with previously stored memory (Mastin, 2010). Human memory is associative in that new information can be remembered better if it can be associated to previously acquired, firmly consolidated information (Mastin, 2010). The various pieces of information are then stored in different parts of the brain (Mastin, 2010). Though the exact method by which this information is later identified and recalled has yet to be discovered, it is understood that ultra-short term sensory memory is converted into short term memory which can then later be consolidated into long term memory (Mastin, 2010).

The formation of new memories requires protein synthesis dependent changes in synaptic structure and plasticity in the hippocampus. Studies in humans and animals suggest that these memories are initially stored in hippocampus but later transferred to cortex for permanent storage. This phenomenon is described as systems consolidation of memories. While the specific role for new protein synthesis in hippocampus in early encoding of memories is established, whether protein synthesis in medial prefrontal cortex play a major role in encoding of memories is unclear. To address this question, we used contextual fear conditioning (CFC) of mouse, a behavior training that induce long lasting memories. A single training session produces robust lifelong memory (8) that can be measured using automated procedures (9). Several studies have used CFC training as a model to study hippocampal-cortical communications and mechanisms underlying systems consolidation of memories. Contextual fear memories are initially stored in hippocampus and then moved to medial prefrontal cortex (mPFC) for long-term storage.

This paper explores two published journals that report on results from research conducted on human brain. The first journal, Parkin, Alan J (Parkin,1996) suggests that brain-damaged patients such as amnesia are related to the hippocampus and also existing memories. The second journal from Deborah E. Hannula (Hannula, Tranel, Cohen, 2006) suggests that hippocampal amnesia results in both short-term and long-term memory. Together, these findings suggest that hippocampal damage can affect the memory.

Long-term potentiation refers to the steady increase in synaptic activity between two neurons which causes persistent strengthening of synaptic activity. Since memory formation is mainly dependent on synaptic strength, LTP seems to play an essential role in memory formation. Contrary to that, long-term depression causes a reduction in synaptic activity between two neurons, causing a decrease in synaptic activity. LTP and LTD are essential for normal functioning of the brain and balance in the ratio of LTP/LTD is needed for homeostasis. The levels and activity of LTP and LTD are majorly dependent on Calcium levels, Calcium-Calmodulin Kinase, NMDARs (N-Methyl-D-Aspartate receptors) and AMPARs (α-amino-3-hydroxy-5-methylisoxazole-4-propionic

The hippocampus plays an essential role in long term memory (Memory loss & the brain, 2010). An assumption that many people have is that memories are stored in the hippocampus, which is not true. A simpler way to imagine the hippocampus’s role in long term memory is to think of it as a door that information must go through to get permanently stored in the brain (Memory loss & the brain 2010). After a memory has passed through the hippocampus and is stored permanently it will stay there despite damage to the hippocampus (Bird, Burgess. 2008). The hippocampus’s role in spatial navigation has been and still is a controversy (Bird, Burgess. 2008). However, over the years research has been done to find that the hippocampus is essential in spatial navigation, but the controversy now is how? (Bird, Burgess. 2008). What is known

Hippocampus is a small, curved region, which exists in both hemispheres of the brain and plays a vital role in emotions, learning and acquisition of new information. It also contributes majorly to long term memory, which is permanent information stored in the brain. Although long term memory is the last information that can be forgotten, its impairment has become very common nowadays. The dysfunction is exemplified by many neurological disorders such as amnesia. There are two types of amnesia, anterograde and retrograde. Anterograde amnesia is inability in forming new information, while retrograde refers to the loss of the past memory. As suggested by Cipolotti and Bird (2006), hippocampus’s lesions are

Synaptic plasticity refers to a process through which the brain undergoes neural changes due to alterations in synaptic strength. Many studies have demonstrated that these synapses have the ability to strengthen or weaken on account of synaptic activity. In other words, an increase in synaptic activity will further strengthen that connection, making it more sensitive to a particular stimulus. Conversely, a decrease in synaptic activity will weaken the connection such that it loses its sensitivity to a given stimulus. The neuronal events that result in the strengthening or weakening of a synapse are explained through two mechanisms – Long-Term Potentiation (LTP) and Long-Term Depression (LTD). In fact, scientists believe that the coupling of these two mechanisms essentially contributes to memory and learning of an individual.

Some scientists believe that parts of long term memory are permanent while others will eventually weaken over time. (3) Long term memory can be divided into three sections: procedural memory, declarative memory, and remote memory. Procedural memory includes motor skills such as learning how to ride a bike or how to drive a car. "Such memories are slow to acquire but more resistant to change or loss." (4) Declarative memory is used to remember facts, such as names, dates and places. It is easy to learn but also easy to lose. Finally there is episodic memory, which is the record of events that a person stores throughout his or her experience. Recent studies show that these events, as soon as they occur, are sent to a temporary part of the brain called the hippocampus, and that over time they are moved to the neocortex for permanent storage. (5).

Doctors and scientists dispute the exact role of the hippocampus, but agree that it has an essential role in the formation of new memories about personally experienced events. Some researchers prefer to consider the hippocampus as part of a larger medial temporal lobe memory system responsible for declarative memory. When a long-term, declarative memory is made, certain neuronal connections in the temporal lobe are strengthened, and others are weakened. These changes are fairly permanent, however some may take weeks or months before they are complete

Nowadays, scientists have making some research about the happiness on people. They try to find the way of making people happy. At the beginning, as always, they use mice. They put some positive feelings into mice memory during sleep. According to scientists; it is possible to make both mice and humans happy by this way.

The two concepts that I resonated with are Memory and the Psychodynamic theory. Starting with the Psychodynamic theory is an approach to psychology that studies the psychological forces underlying human behavior, feelings, and emotions, and how they may relate to early childhood experience. This theory is most closely associated with the work of Sigmund Freud, and with psychoanalysis, a type of psychotherapy that attempts to explore the patient’s unconscious thoughts and emotions so that the person is better able to understand him or herself. The second one is Memory; understanding how memory works will help you improves your memory. Which is an essential key to attaining knowledge. Memory is one of the important cognitive processes. Memory involves remembering and forgetting. I chose the two concepts because throughout the class they stood out to the most. Understanding the conscious, subconscious mind and also memory. I’m interested in understanding the human behavior.

"I lost my keys again," my mother exclaimed at dinner a few nights ago, "I really am getting old." This use of old age as a justification for memory deficits is extremely common. Many people relate old age with loss of memory and other neurobiological functions. Why is it that aging seems to go hand in hand with losing and forgetting things? Is there a neurobiological explanation for this phenomenon?

Without the hippocampus, the information from the short-term memory (STM) cannot be stored in long term memory (LTM). The hippocampus is a very important part of the human brain to store our memories. If we lost it, we will lose all our conscious memories. From Henry’s case, it also discovered that there are multiple memory storage areas located at different parts of the brain while the hippocampus is important to consolidate short-term memory to long-term memory. The removal of hippocampus caused Henry to suffer until he died as he lost the ability to make new conscious