Meningitis: Pathophysiology

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Meningitis – Pathophysiology Meningitis occurs from microbes binding to nasopharyneal cells in an individual and then cross the mucosal barrier
This cell attaches to the choroid plexus and enter the CSF
Since the CSF flows in the subarachnoid space, infection spreads rapidly through the coverings of the brain
Inflammatory response to infection leads to increased ICP, and pia arachnoid layers become edematous
It also leads to purulent exudate that covers the surface of the brain and fills the sulci, causing the surface to appear flat
The exudate is present in the CSF, and the blood vessels on the surface of the brain which appears diluted
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