Methotrexate And Its Effect On Sarcoidosis Essay

1255 WordsOct 26, 20156 Pages
Methotrexate and its effect on sarcoidosis Amanda Roll University of Cincinnati Cronstein, B, Eberle, M, Gruber, H, & Levin, R (1991). Methotrexate inhibits neutrophil function by stimulating adenosine release from connective tissue cells. Proceedings of the National Academy of Sciences, 88, 2441-2445. Abstract Sarcoidosis is a potentially chronic inflammatory disease/disorder that causes abnormal tissue clusters in various parts of the body. Depending on where they form, they can interrupt or prevent function of that specific part of the body. They can form in multiple areas. Its effects also depend on the person, as some people are asymptomatic. Others use medications, like corticosteroids, to treat their symptoms. However, methotrexate is not a corticosteroid, but can be used to treat the symptoms of sarcoidosis; because of this, it is referred to as a “steroid-sparing” agent. Both types of medications can be used together in therapy. Methotrexate acts to increase the release of adenosine in the body to inhibit the cell’s ability to induce tissue damage, preventing the autoimmune characteristic of this disease. Knowing this, we’re one step closer to determining what causes the development of sarcoidosis, and can further investigate ways to treat it. Discovering another form of treatment could possibly help prevent innocent patients from experiencing some dangers and side effects methotrexate causes, like hepatotoxicity. Introduction Sarcoidosis is

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