Micro-CT Case Study

Osteoporosis is marked by a decreased bone volume. Loss of spongy ("cancellous") bone is greater than

The management of osteoporosis patients start with the diagnosis by rolling out secondary causes and then confirm it by measuring bone mineral density (BMD). After that, begin the treatment with lifestyle changes, pharmacological medications, and surgery for some fractures if needed. In this essay I will cover generally the diagnosis, treatment, and prevention of osteoporosis in five steps.

Osteoporosis is a detrimental bone condition, the tissue in the bones deteriorate and thus the bones become progressively brittle which presents a risk for rupture. Osteoporosis impacts more than 44 million Americans and is linked to a suggested 2 million bone fractures each year. According to the National Osteoporosis Foundation, the amount of fissures due to osteoporosis may escalate above 3 million by the year 2025. Osteoporosis is typically undetected and advances with slight warning signs until a fissure ensues. Effects of osteoporosis encompass height reduction and a curved upper back, anyone can have osteoporosis, however it is prevalent in elderly women and many may break a bone due to this condition. Recovery and prevention are vital in combating osteoporosis, though it may never be eradicated one can take measures to stabilize bone density and gain strength.

Osteoporosis is a disorder of bones that affects bones making them low in bone mass fragile and will lead to bone fracture. Bone fracture will easily occur as this disease cause the matrix inside the bone become weak and brittle.Bones can become so brittle due to activities such as coughing can cause fractures.According to Macgill (2015) the origin of the word osteoporosis explain the condition of ‘osteo’ is for bone and ‘porosis’ means porous that resulting in weakness. At this condition, the bone tissue is mineralized normally, but the production is not enough to preserve the normal skeletal architecture. 80% of women and 20% men of 28 million American are affected with the osteoporosis. Approximately, women with the age of 50 will develop osteoporosis. Thin bones are the cause of 1.5 million fractures a year. As in Malaysia, the statistic shows that osteoporosis related to fractured is the common health problem especially in elderly..

As generally stated in the introduction, osteoporosis is a skeletal disorder that involves the strength and integrity of one’s bones. The WHO defines osteoporosis as, “a systemic skeletal disorder characterized by low-bone mass, deterioration of bone tissue, increased bone fragility, and its susceptibly to recurrent fractures.” 2 The most important factor to take into account when addressing osteoporosis is the mass of bone, also referred to as, bone mineral density (BMD). As bone mass begins to decline, typically in the older population, specifically postmenopausal women, individuals are at an increased risk for fractures.3 As a result of this serious condition, many people are affected by morbidity, mortality, and economic difficulty.1

Osteoporosis is a disease in which bone tissue is normally mineralized but the mass of bone is decreased and structural integrity of trabecular bone is impaired. Cortical bone becomes more porous and thinner, making bone weaker and prone to fractures. The World Health Organization (WHO)(1994) has defines postmenopausal osteoporosis abased on the bone density. Bone density is based on the number of standard deviations away from the mean bone mineral density of a young adult reference population, a T-score. Normal bone mass density is 0 to -.99 standard deviations, low bone density (osteopenia) is -1.0 to -2.49 standard deviations, osteoporosis is labeled as less than or equal to 2.5 standard deviations, and severe osteoporosis is less than or equal to 2.5 standard deviations and included a bone fracture.

Osteoporosis is a degenerative disease of the bones generally brought on by the process of aging, unfortunately there can also be a number of underlying or secondary causes; however, preventative care and drug treatments can minimize the severity of this prevalent disease. Osteoporosis has been estimated to affect more than 200 million people worldwide (Bethel, 2015). According to the National Osteoporosis Foundation, 9.9 million Americans have osteoporosis and an additional 43.1 million have low bone density.

Osteoporosis is an age related disorder, more common in females compared to males. Osteoporosis is defined as a “skeletal disorder characterized by compromised bone strength predisposing to increased risk of fractures (Manolagaas, 2014). Osteoporosis is defined as “a disease characterized by low bone mass and deterioration of bone tissue (What is osteoporosis?2014). Osteoporosis is sometimes also referred as “silent thief” as the bone loss occurs very slowly and silently without any symptoms (Osteoporosis facts & statistics.2014). The most common site for fracture due to osteoporosis is hip followed by humerus (Woltman & den Hoed, 2010) . Osteoporosis can occur at any age, although it is a disorder common in females (especially post-menopausal females). Everyone is prone to osteoporosis (Osteoporosis facts & statistics.2014). According to Osteoporosis Canada, 1 in 3 Canadian females and 1 in 5 Canadian males may suffer fractures due to osteoporosis during their lifetime (Osteoporosis facts & statistics.2014). Canadian health care system spends 1.2 billion dollars for the acute hospitalization caused by osteoporosis and in 2010 the health care system spent 3.9 billion dollars for the total treatment of osteoporosis (Osteoporosis facts & statistics.2014). Osteoporosis can be screened and diagnosed by various methods; however the dual energy x ray absorptiometry (DXA) is commonly used. If the T-score values are less than -1 and greater than -2.5SD it is termed as osteopenia,

Osteoporosis is a major public heath treat for more than 28 million Americans, 80 percent of whom are women. In the U.S. today, 10 million individuals

Osteoporosis is commonly known around the world as the numbers continue to increase every year. Osteoporosis is known to cause problems in middle aged women and occasionally effecting some men (1), currently reaching the number of 200million women diagnosed with osteoporosis (2). Arthritis Organisation states that anyone can get osteoporosis but women are about four times more likely than men to develop it, with two main reasons contributing to this fact. For several years after menopause occurs (ovaries stop producing oestrogen), the process of bone loss speeds up, increasing the chance of being diagnosed with osteoporosis. Yet men generally reach a higher level of bone density before the process of bone loss begins. Although

There are two types of osteoporosis that have been identified which are primary and secondary. Osteoporotic bones are thin and brittle and are prone to fracture. The bone loss involves both compact and spongy bone. In type I osteoporosis, which occurs typically in postmenopausal women, spongy bone loss predominates, occurring most prominently in the vertebrae and distal radius (Gueldner, Burke, Smiciknas-Wright, 2000). Major complications of type I osteoporosis are crush fractures of the vertebral bodies and the distal end of the radius. Type II, or old-age, osteoporosis is characterized by a proportional loss of compact and spongy bone of the long bones (Gueldner, Burke, Smiciknis-Wright). The most serious fractures of old age are those of

Osteoporosis is a disease of bone that leads to an increased risk of fracture. In osteoporosis the bone mineral density (BMD) is reduced, bone microarchitecture is disrupted, and the amount and variety of non-collagenous proteins in bone is altered. Osteoporosis is defined by the World Health Organization (WHO) in women as a bone mineral density 2.5 standard deviations below peak bone mass (20-year-old healthy female average) as measured by DXA; the term "established osteoporosis" includes the presence of a fragility fracture.[1] Osteoporosis is most common in women after menopause, when it is called postmenopausal osteoporosis, but may also develop in men, and may occur in anyone in the presence of particular hormonal

The term osteoporosis describes bone loss that is extensive enough to increase the risk of fracture. The term is a general one, not related to any specific cause for the bone loss. Nearly all people with OI have osteoporosis, because they do not develop appropriate bone mass at any age. Women and men with OI can experience additional bone loss, such as age-related bone loss, superimposed on a background of OI. Symptoms of additional bone loss may appear at a younger age than commonly seen in people who don’t have

Osteoporosis can be detected by using dual-energy x-ray absorptiometry (DXA) scans. According to Rozental, Shah, Chacko and Zurakowski (2010), DXA is currently the gold standard for assessing bone mineral density. Once the elderly have found out they have osteoporosis, most turn to traditional therapies which include biphosphonates. Biphosphonates are the most widely used drug for treatment and prevention of osteoporosis. According to Mamtani and Kulkarni (2009), biphosphonates inhibit osteoclast actions that reduce bone resorption. In simpler terms, these drugs increase bone mineral density and decrease bone breakdown in individuals. It also reduces the risk of fractures and prevents

It is also estimated that over 200 million people worldwide suffer from osteoporosis. In the United States and Europe alone, nearly 30% of all postmenopausal women are currently suffering from the disease. Since osteoporosis is highly associated with bone fractures, it is estimated that it causes over 8.9 million fractures worldwide each year, which results in a bone fracture every 3 seconds. It has also been shown that once a person has sustained an initial bone fracture due to osteoporosis, there is an 86% increase in probability that they will sustain an additional fracture. By 2050, projections are estimating that the worldwide incidence of hip fracture in women will increase by 240%, while it will increase by 310% in men. This will mean that the number of hip fractures due to osteoporosis will increase from 1.66 million cases in 1990 to 6.26 million cases by the year of 2050 (International Osteoporosis Foundation, 2015). The picture below shows this