Mild Brain Injury Research Paper

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Concussion or mild traumatic brain injury (mTBI) represents the most common type of traumatic brain injury (TBI). Even though this type of TBI is called “mild”, the effect on the family and the injured person can be devastating. Concussions can be tricky to diagnose and there is no specific cure for concussion. There is growing recognition and some evidence that mild mechanical trauma resulting from sports injuries, military combat, and other physically engaging pursuits may have cumulative and chronic neurological consequences [3, 4]. However there is still a poor understanding of concussions and their effects. Studying mild brain injury in humans is challenging since it is restricted to cognitive assessment and brain imaging evaluation. Animal models provide a means to study concussions in a rigorous, controlled, and efficient manner with the hope of further diagnosis and treatment of mTBI.…show more content…
Although these models were reported to produce graded severities of brain injury with similar morphology to the clinical condition, they present their own limitation. The severity of injury induced by an acceleration injury (weight drop) is often highly variable. Mild CCI cause focal contusion and subrachnoid hemorrhage are not commensurate with the typical concussion in humans. CCI and FPI require craniotomy/ craniectomy which are not clinically relevant. While blast injury is more controversial model with little standardization in blast modeling with regard to the duration of exposure and measurement of peak overpressure. An updated concussive animal model is necessary to replicate the important features of the injury in patients with mTBI as closely as
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