Mineralocorticoids: The Role Of Hormones In The Human Body

Cortisol plays a major role in the development of this disorder. It is secreted by the adrenal gland, located above the kidneys, in a precise sequence of events. The hypothalamus directs corticotropin-releasing hormone(CRH) to the pituitary gland.1 CRH causes the pituitary to release adrenocorticotropin hormone(ACTH) activate the adrenal glands.1 The adrenal glands pick up the ACTH, they reciprocate by releasing cortisol in the bloodstream.1 Cortisol helps with quite a few of your body functions. Some of these functions are stress response, balancing the effects of insulin, reducing the immune system’s inflammatory response, regulating

*Endocrine glands produce – hormones, they work with other hormones to perform many functions including: control water & electrolyte balance, regulating carbohydrate metabolism, working as neurotransmitters, maintaining stress & inflammation, regulate reproductive functions

Alongside with organs, bones, and tissues, the human body also functions through hormones. Some of these hormones are produced by the adrenal glands which are located right above the kidneys. Adrenal glands produce hormones that give vital instructions to almost every organ and every tissue in your body. When someone’s adrenal glands do not produce enough amounts of certain hormones such as cortisol and aldosterone, this often leads to Addison’s Disease.

The adrenal glands, located above the kidneys, are where natural hormones and steroids that the body uses are secreted and regulated. These hormones and steroids come from either the adrenal cortex, or the adrenal medulla. Hormones from the cortex start at the pituitary gland where ACTH or adrenocorticotrophic hormone is secreted. “ The adrenal cortex secretes hormones known as corticosteroids, or cortical steroids.”( Rather, Spencer) There are three zones of the adrenal cortex, the zona glomerulosa, fasciulata, and reticularis. Each of these zones produce specific steroid hormones. Two main types of steroids among many others are Cortisol and Aldosterone. Cortisol is referred to as the stress hormone as it is involved in the response to stress and anxiety. Aldosterone increases reabsorption and retention of sodium and water in the kidneys. This process involves secretion of potassium and is stimulated by low blood sodium, this increases blood volume and

The adrenal glands are made up of two different sections. The interior (medulla) which produces hormones similar to adrenaline. The (cortex) outer layer has the role of producing a group of hormones that are called corticosteroids; these include mineralocorticoids, glucocorticoids and the male sex hormones known as (androgens).

Testosterone belongs to a class of male hormones called androgens that is vital for sexual and reproductive development. The National Institutes of Health regards “testosterone as the most important male hormone”(Rettner). Although the primary role of testosterone directly relates to males, women also produce testosterone at lower levels. Women’s total levels are about a “tenth to a twentieth of men’s levels”(Rettner). According to the Mayo Clinic, this hormone plays a role in sex drive, sperm production, fat distribution, red cell production, and maintenance of muscle strength and

Cortisol production is stimulated by ACTH secretion from the anterior pituitary via numerous feedback mechanisms according to the circadian rhythm, with peak levels in the early morning and smaller fluctuations throughout the day. ACTH secretion is stimulated by CRH in the hypothalamus which is stimulated by things such as: decreases in plasma cortisol, hypoglycemia, stress, and infection. Secretion of ACTH leads to conversion of cholesterol to cortisol in the zona fasciculata of the adrenal gland via various cytochrome P450 enzymes. Increased levels of cortisol itself cause negative feedback on the pituitary and hypothalamus. The zona glomerulosa is the site of production of Aldosterone, the principal mineralocorticoid, via similar mechanisms (cytochrome p 450.) Aldosterone production is stimulated by activation of the renin angiotensin system in response to decreased intravascular volume (sensed by baroreceptors), decreased sodium levels sensed in the macula densa of the nephron, and by the sympathetic nervous system in response to stress.

The Endocrine System is made up of the pituitary gland, thyroid, parathyroid, pancreas, thymus, ovaries, testes, adrenal glands, and the hypothalamus. These glands secrete hormones that help maintain homeostasis in the body. The endocrine system releases hormones that promote growth, development, reproduction, and metabolism.

usually will require the patient to take these drugs for life. It is receive a

Tropic hormones are hormones that target other endocrine glands to release other hormones. For the purpose of this report only Adrenocorticotropic hormone will be further described. After Corticotrophin-Releasing Hormone (CRH) is released from the hypothalamus it encounters Corticotropes in the anterior pituitary gland. Corticotropes release ACTH and as a result and the hormone travels to the Adrenal gland cortex where it will prompt the adrenal gland to release corticosteroids. There are three types of corticosteroids in the Adrenal Gland: mineralocorticoid, glucocorticoid, and androgen. Mineralocorticoids release aldosterone which promote sodium and water reabsorption. Glucocorticoids prevent hyperglycemia (low glucose levels) with the help of cortisol that influence energy metabolism to increase blood glucose levels. Androgens secrete testosterone that promote male characteristics. The adrenal medulla releases two different type of hormones known as endorphins that works as the body's natural pain killers and Melanocyte-stimulating hormone (MSH) that aid with the formation of skin pigmentation. Now that a brief understanding of the endocrine system was discussed I will move on to how a disruption of these mechanisms can result

Adrenal glands are endocrine glands that sit atop the kidneys (Shier et al., 2009). The adrenal glands secrete hormones that increase heart rate, the force of cardiac muscle contraction, breathing rate, elevate blood pressure and blood glucose level. This activity prepares the body foe energy expending action, sometimes called fight or flight responses (Shier et al., 2009).

Thank you for this information that you added on this assignment. The adrenal glands play an important role in the body, and they are located above the kidneys which secrete many hormones essential for the body's normal functions. People with adrenal insufficiency do not produce enough of two vital hormones, called cortisol and aldosterone. Cortisol's most important function is to help the body respond to stress, such as surgery and illness, and recover from infections. Therefore, treatment of adrenal insufficiency results focuses on replacing or substituting those hormones “cortisol and aldosterone”. Cortisol deficiency is treated with replacement oral glucocorticoid medication. Prednisone or hydrocortisone is used most commonly. Fludrocortisone

Hormones job in the body is to control some specific organs for example endocrine, aldosterone etch but the other organ systems have their own control system that doesn’t need hormones. As we grow changes happen in our body, our hormones level changes this could mean that they may increase, decrease or stay the same for example, an endocrine tissue may make less of its hormone than it did when you were 20 year old, or it may make the same amount at a slower level. Generally, hormones decrease, some do not change, and some rise with age. Hormones that usually decrease include; Aldosterone is hormones that help control blood pressure and the balance of fluids and electrolytes in the blood if this is decreased could cause Addison’s disease, calcitonin

Whereas, the hormones produced by the adrenal cortex will deal with long-term stress. There are two major hormones that made by adrenal cortex, which is mineralocorticoids and glucocorticoids.

Adrenal glands, located near the kidneys, secrete several hormones that are activated by the nervous system. These hormones dictate the body’s reaction to stressful situations. Each person secretes a different amount of hormones, therefore affecting behavior in stressful situations differently (Morris & Maisto, 2005).