Miracles and Tragedies with Stem Cell Treatment
Abstract:
This research paper will discuss about some life impacting cases from various sicknesses using stem cell treatments. It will cover a case in which have given people another chance to live a normal life. In one of the cases, the stem cell treatment has been able to cure a fatal genetic disease called RDEB for two young brothers. The second will show that after autologous stem cell transplantation a woman had died two days after.
A stem cell is a cell that can go on to become, basically, a different cell. What this means is that a stem cell isn’t programmed specifically to a job in the body, so with that the stem cell could be used to cure a sickness or a disease. Using the
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The children’s skin is so astonishingly fragile that with minimal friction, tearing and blistering can occur, consequently leading to painful wounds and scarring. (Thomas H. MaughII page 1) Since solid food provides erosion of the esophagus. Nate has been forced to eat pureed food But death most likely comes from malnutrition, infections, or aggressive skin cancer.
The only treatment has been to keep the sick children wrapped in bandages to protect and hold the skin preventing fatal complications. (Josephine Marcotty page 2, Thomas H. Maugh II page 1)Until now, Dr. Angela M. Christiano of Columbia University Medical Center developed an idea of using circulating stem cells to treat the disease in mice. ( Thomas H. Maugh II page 1) Along with Dr. John Wagner and Dr. Jakub Tolar a blood specialist at the University of Columbia helped Nate get the cells he needed in a full transplant using cord blood and bone marrow.(Josephine Marcotty page 2) This is the first time that cells from a bone marrow and cord blood had been used to treat the disease or condition that does not involve blood.
Researchers at the Columbia University, which particularly specialize in adult stem cells, began experimenting with all sorts of stem cells located in bone marrow and blood from umbilical cords. Dr. Jakub Tolar tried 10 to 15 different types of cells in the genetically engineered mice, praying that one would
What is a stem cell? A stem cell is an unspecialized cell, meaning it is not a heart, brain, or any other type of cell that has a special purpose,
The first type of stem cell, an embryonic stem cell, is known for being able to continuously multiply, as well as for being pluripotent. They can be “derived in vitro from the blastocyst of an embryo usually left over from in vitro fertilization” (Forraz & McGuckin, 2011, p.61). Unlike other types of stem cells, embryonic stem cells have yet to be used in any kind of clinical treatment of patients. The high risks of “immune rejection” or “teratoma formation” are serious obstacles (Harris, 2009, p.182). The second type of stem cell, adult stem cells, is primarily considered to be multipotent and may be found in “specific adult human tissues” such as the skin or bone marrow, just to name a few. Over the last twenty years, the amount of scientific research and trials using adult stem cells has grown significantly, despite their lower potency than embryonic stem cells (Forraz & McGuckin, 2011, p.61). Lastly, cord blood stem cells, are technically considered to be a special type of adult stem cell, but their youthful properties give them “greater restorative and regenerative potential.” Directly following the birth of a child, these stem cells can be collected from the blood in the umbilical cord (Steenblock & Payne, 2006, p.9). Embryonic, adult, and cord blood stem cells
Here's the scoop: As originally reported late last year in the medical journal Blood, Dr. Catherine M. Verfaillie and other researchers at the Stem Cell Institute, University of Minnesota, have discovered a way to coax an adult cell found in the bone marrow to exhibit many of the attributes that supposedly make embryonic stem cells irreplaceable to the development future "miracle" medical therapies(Catherine).
is a stem cell? Well basically they are cells in the human body that exist in a sort of neutral
For as long as humans exist, optimal health continues to remain vital for a productive life. As new medical discoveries increase through generations, humans become healthier, therefore, their life expectancy rises. Stem cell research, a relatively new field, investigates to improve and lengthen human life. The possibility of stem cells to develop prospering health makes them beneficial to the human race.
First of all an understanding of what a stem cell is, where it comes from, and the significance of it's medical potential is essential. Stem cells are the "master cells" that form the human body or whatever other animal it is from. Stem cells can be extracted from adult tissues, bone marrow, umbilical cord blood ( ), and embryos in the blastocyst stage. Although scientists have found ways to manipulate the stem cells from adult sources into other types of cells, they claim that they are less capable of deriving the desired tissue and are not "biologically equivalent" ( ) to stem cells extracted from embryos.
Stem cells get their name from the fact that they are basic cells that other cells develop from. They are capable of developing into a wide range of cells. Stem cells could potentially be used to grow new cells to replace the cells that were destroyed or damaged by
In the past two decades, many technological and scientific advances have been made in order to make life easier for many people who suffer from cancer, disease and sickness. Among these advances there is something revolutionary called stem cells. Stem cells can help restore and regenerate almost all parts of the human body such as the heart, kidney, liver, and many other organs. Although stem cells offer a lot, there are many views against and for stem cells, and among these views lies the debate of whether stem cells should be legalized or not (NIH 2). Stem cells offer exciting new opportunities in the field of science such as regenerating human body parts, but many people are still debating whether or not the use of stem cells is
Stem cells are cells which can essentially form into any type of cell that can be found in the body. There are various types of stem cells. These include embryonic, adult, genetically reprogrammed adult stem cells, and perinatal stem cells. The most versatile, as well as controversial, type of stem cells are embryonic stem cells. These cells are found in 3-5 day old embryos which are formed through in vitro fertilization ("Stem Cell Basics" 1). While scientists have been able to reprogram adult stem cells to act as if they were embryonic, there is yet to be any conclusive evidence as to how the use of the altered cells will affect humans ("Stem cells: What they are and what they do" 1). The use of stem cells is largely focused on regenerative medicine which takes advantage of the stem cells versatility to create and replace damaged tissues in
The transfer of information, often shared through scientific reports and research, puts this topic in a highly international spotlight. Many supporters believe that stem cells will be able to help solve once untreatable diseases or injuries such as spinal cord injuries, skin burns, Parkinson’s disease, and some blood disorders. However, the main argument is if stem cells should be used in finding therapeutic treatments. The use of embryonic stem cells is viewed by many as a moral inconsistency; it is opposed by religious organizations and individuals believing that this research should be abandoned and existing, alternative methods be adapted.
Attempts were made to fertilize mammalian eggs outside of the human body and in the early 1900s, it was discovered that some cells had the ability to generate blood cells. In 1968, the first bone marrow transplant was performed to successfully to treat patient’s severe combined immunodeficiency. There have been many stem cell discoveries since the early 1900’s but the two majors were in 1998 when, Thompson, from the University of Wisconsin, isolated cells from the inner cell mass of early embryos and developed the first embryonic stem cell lines. Then, in 1999 and 2000, scientists discovered that manipulating adult mouse tissues could produce different cell types.
Adult stem cells are not necessarily derived from adult human but merely not from embryos. These stem cells can found in bone marrow, connective tissues, hair follicles, umbilical cords and other areas of the body. It is said that these cells have been used to treat an estimated 11,000 patients in the United States in the past two years alone, and over 70 diseases, including Parkinson’s and diabetes. (Pence, 2009) There have been 0 recorded successful treatments achieved by the use of embryonic stem cells. As well, stem cells from umbilical cord blood have been used to treat 65 diseases such as leukemia, and lymphoma. (Sweat,
Scientists and researchers believe that Human Embryonic Stem Cells hold potential cures for numerous diseases in today's society, including multiple sclerosis, Parkinson's disease, Alzheimer's disease, diabetes, Lou Gehrig's disease, Hodgkin's disease, hundreds of immune system and genetic disorders, spinal cord injuries, heart disease and just about every type of cancer. In today's world there's over a million Americans who suffer from deadly diseases, not only adults but innocent children that deserve to live a healthy life. These deadly diseases can be cured or treated in a more effective way than they are treated now with the help of the human embryonic stem cells. According to the Poll on "American views on stem cell research in the wake of the death of Ronald Reagan" which was prepared for results of America, shows that a sum of 73% highly supports and somewhat support this controversial process (Results of America, 2004). Even though this topic has brought continuous political attacks and very limited funding, Human Embryonic Stem cell research has made considerable contribution to the battle against disabilities and incurable diseases. A great example of success by using human embryonic stem cells was made by Dr. Hans Keirstead in the Roman Laboratory at UC Irvine; he restored myelin insulation around damaged nerves, returning motion to partially paralyzed rats. (Journal of Neuroscience, 2005) .
Parkinson’s disease, Lou Gehrig’s disease, Sickle Cell Anemia, Alzheimer’s. This world is plague by countless diseases and there existed a time where, after many failed research attempts, scientists began to believe that people would always suffer from these diseases. However, with the introduction of stem cell research those past notions were dismissed. Upon their introduction, stem cell’s provided a new hope to the world and it proved itself to be an invaluable asset. Through stem cell research, a multitude of cures have been brought upon the world and these diseases that were uncontrollable in the past, can now be regulated and the ones suffering from now have a chance at living a better life. Sadly, there are many people who
Stem cells are cells that have the capabilities to develop into many different types of cells in the body. Serving as a type of repair system for the body, they can theoretically divide without limit to take over for other cells for