Molecular Profiling Of Liver And Early Diagnostic Biomarker Test Development

In this experiment, the hypothesis was that if living cells in beef liver is related to the pH of water, then the pH of liver will respond more like water when acid or base is added. According to the data shown above, the pH level declined (from 8 to 1) with the increase number of HCL (acid) drops added to tap water. Whereas the pH level increased ( from 8 to 13) with the increase of NaOH (base) drops added to the tap water. In contrary, the pH recorded in liver did not show this similar pattern as the tap water at all, in fact it showed a constant pH of 7 as drops of HCL and NaOH were added increasingly. The data for liver showed a slight decrease and increase in pH when acid and base was added beyond 20 drops, but was not as significant as tap water. Thus the hypothesis was refuted.

Liver cirrhosis, which is the end product of liver disease caused by HCV, is the leading cause of organ transplants in the United States (Hirsch, 2000).

most efficient strategy for assessing fibrosis in patients with chronic HCV infection is to use a combination of

The MD Anderson Liver Tumor biospecimen resource has been invaluable for a large number of studies or clinical development. The sixth and subsequent editions of the American Joint Committee on Cancer (AJCC) staging of hepatocellular cancer, which was developed by an international consortium led by Jean-Nicolas Vauthey, MD, Professor of Surgery at MD Anderson and co-leader on project 2 of the SPORE, was based upon pathologic review of resected specimens in the Liver Tumor Bank (Vauthey JN J Clin Oncol 2002 20:1527-36). In addition, investigators at MD Anderson examined tissues in the Liver Tumor Bank to elucidate the prognostic significance of the ribonucleoprotein Human Antigen R (HuR) showing that patients with high HuR tumor expression had

The increasing number of citizens that are testing positive for Hepatitis C is shocking and the epidemic is just getting worse. One out of every one hundred people in the general population has Hepatitis C, but the ratio is higher in prisons. One out of every six inmates has Hepatitis C (Wegner, Rottnek, Parker and Crippin, 2014). Hepatitis C (HCV) is a blood disease that is caused by a virus and it affects the liver. Unfortunately there is no vaccine to prevent this disease and I have seen first-hand how ugly this virus is. I have worked in the medical field for the past 6 years and I have a very close friend who contracted HCV. Unfortunately, she was one of the many people that needed a liver transplant. HCV has infected four times as

This case study is about Abdul Chidiac, a 51 year old male, married with 4 children. He had a medical history of hypertension, hypercholesterolaemia and cirrhosis with two admissions in the last six months. He is a smoker and drinks beer, 5-6 bottles per day. As Carithers & McClain (2010) explained the patient’s medical history is another indicator of the risk for cirrhosis; the progression to cirrhosis is adaptable and may take time over weeks or many years. Cirrhosis is a liver disease characterized by permanent scarring of the

How Drinking Causes Gut Microbe Imbalance Linked to Liver Disease is an article that builds on the common knowledge that alcohol consumption damages the liver. The liver is the organ in the body that filters out everything in your bloodstream that may harm you, for example alcohol. It also produces a substance called bile that breaks down lipids. For these reasons, the liver is a very important organ in the digestive system in the body and this article shows how alcohol damages it.

Hepatitis C is an inflammation of the liver's cells and tissues caused by the hepatitis C virus (HCV).

There are a number of individuals who may be suffering from an illness and not even be aware they have an illness. One example of such illness is Hepatitis C (HCV). Hepatitis C is a severe disease of the liver. It is caused by the Hepatitis C virus (Centers for Disease Control and Prevention (CDC), 2015). As a result, Hepatitis C has been termed a silent epidemic (CDC, 2015). This is because a lot of individuals have Hepatitis C and don’t even realize they have the infection (CDC, 2015). As the infection begins to progress over time, it could cause acute issues to the liver (CDC, 2015). Those issues could be things like damage to the liver, the liver could fail to function, cirrhosis, or even cancer of the liver (CDC, 2015). However, screening for Hepatitis C will allow an individual to benefit from treatments that are available, hence eliminating the disease from the body and preventing the liver from undergoing any further damage (CDC, 2015).

HCV is the major cause of liver transplantation in Western countries (Roels and Rahmel, 2011).

Levels of normal plasma are (from 0.2to 0.4g/L) .It is manufactured in liver is considered the acute phase protein.

The hepatitis C virus (HCV) is the most widespread blood borne infection throughout the United States. It is estimated that nearly 3.2 million Americans are chronically infected (Centers for Disease Control and Prevention, 2014). HCV is a leading cause of cirrhosis, hepatocellular carcinoma, and is an indication for liver transplant (Medscape, 2012). As a result, HCV poses a significant economic burden on the American health care system.

The decisions to prescribe antibiotics are reliant on clinical examination of symptoms such as fever, sputum discoloration and breathlessness.4 In modern society, no clinical test can produce a flawless diagnosis. However, in an appropriate clinical context, point of care (POC) biomarkers can guide the clinician in determining antibiotic treatment in specific cases, by eliminating severe bacterial infections and identifying patient’s who will not benefit from antibiotics. The systematic review, “Biomarkers as point-of-care tests to guide prescription of antibiotics in patients with acute respiratory infections in primary care,” analysed the research of six studies, to assess whether POC biomarkers integrated with clinical examination is an

The use of biomarker in clinical practice is pivotal and offers great promise to the physician and surgeon to treat the cancer patients with better management plan. With the use of a biomarker, it will ultimately enhance the treatment response and improves patient’s survival and quality of life. The application of biomarkers in practices of medicine however carries several advantageous and disadvantageous.

A healthy liver is necessary for survival, and when the threat of liver cancer looms liver transplantation (LT) is an option. The liver is the bodies largest internal organ. It has many important functions including preventing infections, removing bacteria and toxins from the blood, and more. (“Liver Transplant”, 2012, p.1). Some signs of liver failure are fatigue, loss of appetite, muscle loss, forgetfulness and confusion. The most prevalent sign of liver failure is jaundice, a condition that causes yellowing of the skin and whites of the eyes (“Liver Transplant”, 2012, p.2). Malignancy is the second most common primary diagnoses for needing a liver transplant (Bentley, 2014, p.10). To begin the transplant process, a patient must first get diagnosed. After the diagnosis, there is a waiting time before the transplant can occur. While waiting for a transplant different treatments are available to slow the growth of cancer. Once the transplant is performed there are a variety of things to take into consideration to prolong a patient’s life. The transplantation process is very strenuous and complicated. The process encompasses preparation, the operation, and the post operation.