Molecular Profiling Of Liver And Early Diagnostic Biomarker Test Development

2059 Words Jan 26th, 2015 9 Pages
Molecular Profiling of Liver Transplant Fibrosis and Early Diagnostic Biomarker Test Development

Mu Hao (Jack) Hsu

Table of contents

1. Introduction
2. Liver fibrosis
2.1 Definition
2.2 Pathogenesis of liver fibrosis
2.3 Factors that infects liver fibrosis progression
3. Chronic liver disease 3.1 Definition
3.2 Major causes
3.3 Leading chronic liver diseases for liver transplantation
3.4 Management of chronic liver diseases
4. Liver transplantation
4.1 Indication 4.2 Survival rate
5. Fibrosis progression monitoring and diagnostic techniques
5.1 Invasive techniques
5.1.1 Liver biopsy
5.1.2 Advantages and disadvantages 5.2 Major non-invasive techniques 5.2.1 Serological biomarkers Indirect serological fibrosis biomarkers Direct serological fibrosis biomarkers Combination of indirect and direct fibrosis biomarkers Advantages and disadvantages 5.3.1 Imaging techniques Ultrasound-based transient elastography (TE) Advantages and disadvantages
6. Fibrosis genetic studies in humans
6.1 Single genetic factor studies associated with fibrosis progression in different types of chronic liver diseases in humans 6.2 Combination of multiple genes to predict fibrosis progression
7. Gene microarray
8. NanoString Technology
9. Hypothesis
10. Objective

1. Introduction
Liver fibrosis is the accumulation of fibrous scar tissue that occurs in most types of chronic liver diseases caused by infection,…
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