Most Common Treatments For Heart Failure

1090 WordsApr 6, 20175 Pages
One of the most common treatments for heart failure is ACE inhibitors. ACE inhibitors have shown to slow down the course of heart failure and decrease cardiovascular mortality (1). Overall, they work by suppressing the activity of angiotensin II. ACE inhibitors prevent the conversion of angiotensin I to angiotensin II by competitively inhibiting the activity of the angiotensin converting enzyme. Since angiotensin II is a vasoconstrictor, the lack of the protein allows blood vessels to remain dilated which decreases blood pressure. In addition, the lack of angiotensin II decreases aldosterone release which further lowers the blood pressure and puts less strain on the heart. Angiotensin II has been shown to be involved in the myocardial…show more content…
In addition, the mass of viable myocardium in the treated participants increased relative to the control group. These results indicate that treatment with CDCs was somehow able to shrink the scar tissue and stimulate the growth of myocardial tissue. However, the partial regeneration at the affected regions did not necessarily translate to improved heart function. The ejection fraction of the treatment group only increased from 39% to 41%. It was theorized that the introduced CDCs activated endogenous regenerative pathways through physical contact and the release of paracrine factors. Proposed Therapy: It was originally believed that cardiac stem cells can be transplanted into the infarcted region of a failing heart so that they can proliferate and differentiate into cardiomyocytes to improve the heart’s ability to pump blood. While transplanted cardiac stem cells were shown improve cardiac function in animal trials and clinical trials, it was later discovered that they did so with the release of paracrine factors, not through differentiation. As a result, interest in the use of paracrine factors to promote endogenous cardiac regeneration has increased. A proposed therapy to take advantage of the regenerative properties of paracrine factors is to upregulate, through genetic engineering, a cardiac stem cell’s release of factors SCF and IGF-1. Both IGF-1 and SCF have shown to be potentially useful for heart
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