Essay on Ms Speech Outline

Multiple sclerosis (MS) involves an autoimmune process that develops when a previous viral insult to the nervous system has occurred in a genetically susceptible individual. B lymphocytes, plasma cells, and activated T cells, along with proinflammatory cytokines, cause inflammation, oligodendrocyte injury and demyelination. Early inflammation and demyelination lead to irreversible axonal

Multiple sclerosis, also known as MS, is one of humankind’s most mysterious diseases. No one knows the exact cause and there is no exact treatment. Still multiple sclerosis has the ability to affect nearly 3 million people worldwide and at least 500,000 people in the United States (Boroch). This disease tends to be more common in individuals of northern European descent and women are more than twice as likely to develop multiple sclerosis as men. Of those 3 million people, most of them are between the ages of 20 and 50 years old (Dangond). Even though multiple sclerosis is a mystery disease, scientists are working to determine the exact cause and treatment.

b. Support: In 2007, it was reported that approximately 2.5 million people in the world have MS.

It is suggested by previous studies that the damage of the myelin sheath in MS involves the activation of inflammatory factors including the CD4+ T cells, CD8+ T cells, B cells, macrophages and microglia cells (Luccinetti et al., 1996; Lassmannet al., 2012). However, whether the immune response triggers the onset of MS, or is a consequence of the disease process is currently not clear. Interestingly, several recent studies suggested that the prevalence rate of MS is significantly increased with latitude, which implies that not only the geographical (environmental) differences but racial and ethnic differences may play a role in the worldwide MS distribution (Rosati, 2001; Simpson et al., 2011).

Anyone can develop MS, but many patients share the following characteristics. The majority experiences their first symptoms between ages 20 and 40. Caucasians are more than twice as likely as other races to develop MS. MS is two to three times more common in women as in men. MS is five times more common in temperate climates like those of the northern US, Canada, and Europe. And people whose close relatives have MS are more susceptible to developing the disease, but there is no evidence the disease is directly inherited.

In the world of neurology, there are a vast amount of neurological disorders, conditions, and diseases. One severe disease is known as Multiple Sclerosis. In this research essay, I will be discussing what multiple sclerosis is, symptoms, causes, personal experience, and treatments.

MS(Multiple Sclerosis) is a disease which gradually hardens all tissues and also causes scars. These scars form when the persons immune system's cells go into the central nervous system and cause inflammation to the brain, spinal cord and optic nerves. MS is also a non contagious and unpredictable disease. MS is also the most common chronic disease (when it comes to the CNS (Central Nervous System)) with young Australians. Throughout all the states of Australia, Victoria is the State with the most people that have the condition.

Multiple Sclerosis, commonly known as MS is an autoimmune disease of the central nervous system. Scientists have been studying MS since the 19th century. In MS, the body’s immune system produces cells and antibodies that attack myelin in your brain which is essential for the nerves in your brain and spinal cord to conduct electricity to perform its function. The attack on myelin results in vison loss, paralysis, numbness, muscle weakness, difficulty walking, stiffness, spasms, and bladder and bowel problems. MS has varying degrees of severity and affects people between the ages of 20-50, mostly women. Although there are treatments, there is no cause and cure yet.

Factors such as geography (those in a temperate climate have an elevated risk compared to those in a color climate or whom are near the equator). Race is also indicative of higher multiple sclerosis probability, with Caucasians being the highest, and Asian communities the lowest. A significance has also been directly linked to women who smoke cigarettes to be 1.6 times more likely to develop multiple sclerosis, and all individuals who smoke to have a higher risk for rapid progression of multiple sclerosis. More research is being done on these factors, and they are learning new facts and disproving old theories as they learn. (MSAA)

To scientists, this suggests that exposure to some environmental agent before puberty may cause a predisposition for MS later on in life. There is also evidence that suggests that vitamin D may play a role. This could explain the previous statement that MS occurs more frequently farther from the equator, since that area frequently receives more sunlight which aids in the synthesis of Vitamin D. This possibility is now being studied by a society-funded epidemiological study in Australia [2]. There is also the possibility that a virus earlier on in life may cause, or trigger, MS. Viruses are known to cause inflammation and a breakdown of myelin, so it is possible that a virus that breakdowns myelin may trigger MS. Viruses currently being researched are measles, Human Herpes Virus-6, and Epstein-Barr [3]. Genetically, several different genes are believed to have a role in MS. According the Multiple Sclerosis Foundation, if one parent has Multiple Sclerosis, the risk of their child or children getting the same disease is approximately two to five percent [3].

The main cause of MS is yet to be known, researchers have suggested that MS is a demyelinating disease. Here myelin gets degenerated. Myelin is a material which is composed of fats and provides insulation for the nerves. This insulation of fat contributes in transmission of impulses with very high speed, allowing people to move almost without thinking. Therefore, when this myelin sheath is not present it cause a short circuiting like case and the person cannot move rapidly, smoothly and coordinate movements. According to researchers the immune system mistakes the myelin as a foreign body and attacks to destroy this myelin. It is not known yet what triggers the immune system but it is thought to be a combination of many factors. Among a few theories a virus that lies dormant in the body plays a major role in the causing of this disease by disturbing the immune system or indirectly contribute to the autoimmunity. Another one of the theories also says that it is not because of any specific virus but a common virus like herpes or measles which activates the

(1) One third of a million Americans suffer from MS and a great percentage of those people are women. Women account for 73% of MS sufferers. (2) MS usually strikes young adults between the ages of 20 and 40 years old. (8) There are even some cases of MS being diagnosed in childhood.

Multiple Sclerosis is the leading cause of disability in young adults. The average age at

There are a great number of studies had been conducted to explain the epidemiology of this multiple sclerosis. Some believes that the distribution of this disease is based on the climatic while other assume that it is related to patterns migration and ancestry. Some also believes that it is related to socioeconomic issues that evade awareness and diagnoses.

MS disease has no definite cause. It is rather triggered by multiple factors that work together to result in the disease. According to Medscape, the disease is a result of a combination of infection and/or exposure to chemicals and genetic predisposition to immune system failure (Luzzio & Talavera, 2017). The immune system malfunction destroys myelin. Women are more likely to have MS than