Multiple Sclerosis Research

Multiple Sclerosis (MS) is an autoimmune disease, in which the body's immune system attacks its own tissues. The disease destroys the myelin, which is the insulation that protects the nerve fibers in the spinal cord, and brain (Niino, 2008). When the myelin is damaged, the message that is traveling along that nerve may be slowed or blocked. Symptoms vary by patient, but often include: numbness or weakness in limbs, partial or complete loss of vision, lack of coordination or unsteady gait, slurred speech, fatigue, dizziness, and problems with bowel and bladder functions.

Introduction: Multiple sclerosis (MS) is one of the central nervous system (CNS) diseases that involve the axons of the brain and spinal cord, causing the destruction of the myelin and the axons. Symptoms, severity and course of the disease vary from person to person. It is hard to diagnose MS because its signs and symptoms are similar to some other diseases. Metabolomics is a new method of early diagnosis of many diseases. It is a method of quantitative measurement and systemic approach to study the metabolic profile in vivo. In the present study, the metabolome profiles of patients with MS disease were investigated, by applying NMR spectroscopy.

There are many debilitating side effects and symptoms that accompany Multiple Sclerosis (MS). In MS, the immune system essentially fights itself and attacks its own body’s cells, causing progressive damage in the brain and spinal chord. Some key symptoms and side effects of the disease are vision problems, muscle weakness, and trouble walking or speaking. However, this is not it, There are many more side effects and symptoms that very between individuals. Some of the symptoms that haven't thoroughly been researched are the changes that occur in the brain of an MS patient, especially a pediatric MS patient. There are several existing hypothesis about Multiple Sclerosis’ debilitating effects in the brain, but no concrete research done on the

It is suggested by previous studies that the damage of the myelin sheath in MS involves the activation of inflammatory factors including the CD4+ T cells, CD8+ T cells, B cells, macrophages and microglia cells (Luccinetti et al., 1996; Lassmannet al., 2012). However, whether the immune response triggers the onset of MS, or is a consequence of the disease process is currently not clear. Interestingly, several recent studies suggested that the prevalence rate of MS is significantly increased with latitude, which implies that not only the geographical (environmental) differences but racial and ethnic differences may play a role in the worldwide MS distribution (Rosati, 2001; Simpson et al., 2011).

Two to three more women than men have been diagnosed with MS and most people are diagnosed between the ages of 20 and 50.

To scientists, this suggests that exposure to some environmental agent before puberty may cause a predisposition for MS later on in life. There is also evidence that suggests that vitamin D may play a role. This could explain the previous statement that MS occurs more frequently farther from the equator, since that area frequently receives more sunlight which aids in the synthesis of Vitamin D. This possibility is now being studied by a society-funded epidemiological study in Australia [2]. There is also the possibility that a virus earlier on in life may cause, or trigger, MS. Viruses are known to cause inflammation and a breakdown of myelin, so it is possible that a virus that breakdowns myelin may trigger MS. Viruses currently being researched are measles, Human Herpes Virus-6, and Epstein-Barr [3]. Genetically, several different genes are believed to have a role in MS. According the Multiple Sclerosis Foundation, if one parent has Multiple Sclerosis, the risk of their child or children getting the same disease is approximately two to five percent [3].

Multiple sclerosis (MS) is a potentially disabling disease of the brain and spinal cord, particularly the central nervous system (CNS). In MS the immune system attacks the myelin, which is the protective sheath that covers the nerve fibers and causes communication between your brain and the rest of your body. Eventually, the disease can cause the nerves to deteriorate or even lead to permanent damage. They deteriorate in variable degrees and produce significant disability within 20-25 years in more than 30% of patients, (Luzzio, 2016). The majority of people diagnosed with MS are adults between the ages of 20 and 45; twice as many women are affected compared to men. However, MS can present itself in childhood or late middle age, but is uncommon. According to Goldenberg (2012), there is no known cause for this debilitating disease, but it appears to involve a combination of genetic susceptibility and a nongenetic trigger, such as a virus, metabolism, or environmental factors

MS affects about 400,000 persons in the USA and approximately 2.1 million worldwide. The average age of onset is between 20–40 years, although it can also occur in young children and in people aged 50 years and more. It is estimated that the direct and indirect healthcare costs of MS in the United States result in approximately $35,000 spent per year per patient. Multiple sclerosis affects women more

Multiple Sclerosis is a disease that attacks the brain and spinal cord, the central nervous system. Scientists believe that the disease is caused by an environmental factor that certain genetics are predisposed to respond to. Symptoms can vary from person to person but the most common are blurred vision, loss of balance, poor coordination, slurred speech, tremors, numbness, extreme fatigue, memory problems, paralysis, and blindness. In order to be diagnosed with Multiple Sclerosis, a careful history of symptoms is taken, as well as history of birthplace, family, environment, and other illnesses. A variety of tests are run to rule out other conditions that may have similar symptoms. Most of the people who are diagnosed with Multiple Sclerosis are between the ages of twenty and fifty; yet there are people as young as two and as old as seventy-five who have developed the disease. Although the life expectancy for this disease has increased, Multiple Sclerosis

Multiple Sclerosis is a disabling autoimmune disease that basically attacks the protective sheath of our myelin. The myelin surrounds the nerve fibers and helps orchestrate impulses that our sent to our spinal cord and brain otherwise known as the central nervous system. People who are diagnosed with MS have damaged or inflamed myelin around the nerves causing poor conduction where the impulses are either weakened or lost. With the damaged myelin protective coating, the nerves are then more vulnerable to attack from the immune cells. As we know, immune cells protect the body from foreign substances such as bacteria or viruses. This neurological disease typically manifests in young people between the ages of 20-40 years old. MS is predominately diagnosed in woman more than men and also in Caucasians verses any other races. MS not only affects our ability to walk and talk, but our breathing even relies on proper functioning of the CNS. This disease deteriorates our myelin and is irreversible. Some people diagnosed with MS go long periods in remission while others eventually die.

Multiple sclerosis (MS) is a common disease that causes disruption to the electrical functions of the immune system resulting in cognitive and motor functions to become destroyed. 1 Multiple sclerosis affects 350,000 people in the United States, however; 2.3 million people globally are known to have multiple sclerosis. 2 This disease has throughout the years been on the rise all over the world. This increase could be due to people moving from one region to another. 2 Women tend to be at greater risk of having multiple sclerosis than men. Women typically develop symptoms at the ages of 20 and 40 years while men are known to develop symptoms at a later age. 2 Caucasian women are more susceptible to developing multiple sclerosis while African Americans have a lower chance of getting this disease. 1 Considering that MS is a disease that affects the nervous system, there is no concise explanation as to what causes this disease. Tobacco products have been linked to causing MS as well as some viruses and bacteria. 2 As viruses attack the brain and the spinal cord, the main compartments of our nervous system, this triggers an effect that causes extreme damage to the axons, specifically their mylenated areas.1 Multiple sclerosis triggers pain to the central nervous system, which destroys and prohibits proper functions. This disease is considered as being irreversible because of the damage done to the axons. 2 As damage to the axons is seen, lesions start to develop in the brain and

What causes MS is unknown; Scientists believe there are several factors that cause MS including immunologic, environmental, infectious, and genetic. MS is 2 to 3 times more common in women than men. MS is not inherited but genetics plays an important role in who gets the disease. While most people are diagnosed between the ages of 20 and 50, young children and teenagers may develop this life altering illness. MS is more common in northern latitudes that are further from the equator and less common in areas closer to the equator however, known in all parts of the world. MS occurs in most ethnic groups, including African Americans, Asians, and Hispanics/Latinos, but are more common in Caucasians of the northern European ancestry (“What is Multiple Sclerosis”).

Multiple Sclerosis, also known as MS, is a disease that obliterates the myelin that surrounds the nerve fibers in the spinal cord and the brain. MS is estimated to affect around 23 million people but it does not affect everyone who possesses it the same. There are four types of MS that one can experience; Relapsing-remitting, Secondary-progressive, Primary-progressive, and Progressive-relapsing.

Multiple sclerosis, or MS, is a chronic, autoimmune, and degenerative disease of the central nervous system. Its etiology is unknown, but a combination of environmental and genetic factors is likely responsible for its development. MS occurs when one’s immune system attacks the fatty protein myelin, which insulates and protects the axons of oligodendrocytes in the brain and spinal cord. Damage to this sheath can cause the miscommunication between these oligodendrocytes and the rest of the body, and additionally causes painful and debilitating symptoms. The severity of these symptoms varies from one person to another and is dependent on the extent of the nerve damage and the types of nerves that have been affected. This disease effects one’s motor and cognitive abilities, and can oftentimes lead to severe impairment of one’s movement and speech. There is no known cure for this inflammatory disease, but medication and therapy can help alleviate the effects as the disease progresses.

Multiple sclerosis is an autoimmune disease that damages the myelin sheaths and nervous cells in the central nervous system. An autoimmune disease is when the body produces antibodies to attack its own tissues. Basically, myelin is a mixture of proteins and phospholipids forming a whitish insulating sheath around many nerve fibers, increasing the speed that impulses are sent. It is made by schwann cells in the peripheral nervous system and oligodendrocytes in the central nervous system. Multiple sclerosis attacks the oligodendrocytes and the myelin sheaths causing some very serious problems for people diagnosed with it. The disease affects motor, sensory, and autonomic nerves and has been seen to affect cognitive functions. Females are affected