Muscular Hypertension Essay

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Hypertensive Ocular hypertension (OH) is defined as an increased IOP greater than two standard deviations above 21mmHg (mean=16mmHg, normal range 10-21mmHg) in the absence of optic nerve damage, visual field loss or other pathology that could explain high IOP. Ocular hypertension increases the risk of developing glaucoma especially in persons at high risk. As the ethiologic and pathologic processes of glaucoma disease remain largely unknown, it is crucial to select the appropriate animal models that effectively mimic the condition. Normotensive Intraocular pressure (IOP) is the result of a dynamic balance between aqueous humor formation and outflow. As a main parameter in the evaluation of patients at risk from glaucoma, it also provides the baseline pressure in ocular disease studies. While glaucoma is often associated with elevated IOP, glaucomatous changes in the retina and optic nerve sometimes occur at normal IOP; this is termed…show more content…
Not only do we help clients select the appropriate in vivo efficacy model, but we can also develop new animal models as needed, according to the specific requirements of our clients. We use state-of-the-art ocular technology – including Spectralis® HRA+OCT, confocal microscopy, tomography, electroretinography, and more – to demonstrate the efficacy of particular ophthalmic drugs. Our professional scientists will work closely with you to provide you with the expertise in ophthalmology models and endpoints for your drug program. To learn more about our normotensive and hypertensive intraocular pressure model for your pharmacodynamics study or NCE screening, please feel free to contact us and we will get in touch with you as soon as
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