My Research Project Is Centered On Antibiotic Resistance

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My research project is centered on antibiotic resistance in soil microbes. Treatment with antibiotics is a selective process. Antibiotics are selected primarily for their target pathogens. They also firmly impact the competitive edge of drug resistant versus sensitive strains. Antibiotics stimulate the majority of strains that are resistant to it. Compounds can either transpose or reduce this advantage. Soil bacteria has shown that resistance is prevalent in the environment. Resistance processes present in environmental bacteria have the capability to be clinically pertinent because the DNA found in these bacteria can be allocated via lateral gene transfer. Antibiotic resistance genes, and antibiotics are prone to cause environmental…show more content…
They anticipated that compounds selecting against antibiotic resistance did so based on the bacteria’s physiological interactions with that of tetracycline. The pilot screen results inferred that soil microbes were secreting both forms of the selection-transposing compounds. This indicates that nature has advanced collections of chemicals which offset antibiotic resistance. The results were consistent with the prediction. Using their assay, they discovered that making inverters of selection for tetracycline resistance seemed to be common in soil microbes. Majority of the hits seemed to prefer selection against tetracycline even in the presence of a specified amount of tetracycline. The fusion of compounds that select for or against resistance could provide insight into the concurrence of sensitive antibiotic species found in the wild.
In the second article Mcgarvey, Queitsch, and Fields are attempting to study and identify which genes and or proteins are accountable for generating antibiotic resistance in bacteria. The authors hypothesized that a screening of soil metagenomic DNA library in an Escherichia coli host for genes could project resistance to the following antibiotics: gentamicin, kanamycin, rifampin, trimethoprim, chloramphenicol, or tetracycline. The screen concluded that 41 genes were encoding novel protein variants of about eight families.

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