My Research Project Is Centered On Antibiotic Resistance

The development of antibiotics was an important advancement in 20th century medicine. Previously deadly infectious diseases are now routinely treated with antibiotics. Moreover, for modern-day medical procedures such as chemotherapy treatment to be successful, antibiotic use is necessary. For these reasons, the prospect of bacteria developing widespread resistance to antibiotics is a major concern as it would render many modern-day medical therapies unviable.

The appearance and spreading of antibiotic-resistant pathogens have given rise to many studies involving the genetic

Antibiotic resistance is when microorganisms, such as bacteria, are able to survive an exposure to antibiotics and these bacteria are now resistant to the effects of these antibiotics. Antibiotic resistance in bacteria has been an issue since antibiotics were discovered. The fact that bacteria can become resistant to our medical treatments such as antibiotics is a natural evolutionary process, but there are certain human contributions that definitely speed up the process. For example, one of the main contributions that will be discussed is the problem of over prescription of the antibiotic drugs. The

When antibiotic is used most of the bacteria die but a few bacteria with antibiotic resistance gene survive and reproduce and pass this advantage to their offsprings. This selective pressure exists naturally, however antibiotic misuse can be accused for fastening the spread of the antibiotic resistance gene [Refer to figure 2] (Learn Genetics 2015). Consequently, inappropriate antibiotic intake will lead to a greater chance of superbugs being developed. Antibiotic resistance can be defined as a new ability which a bacterium has developed to stay unattached in the presence of an antibiotic that was previously effective to destroy the bacterium (ABC science 2015). Four key mechanisms that has been identified for bacterial antibiotic resistance can be listed as: producing enzymes that inhibit the functionality of the drug, reducing the effectiveness of the drug by producing targets against which the antibiotic, reducing the permeability of the drug into the bacterium and active export of antibiotics using various pumps (Pogson 2012). All these mechanisms can be developed by any of the bacteria when the corresponding mutated gene of antibacterial resistance is received. The genes code for specific proteins, and variation in the gene leads to alteration of the shape of proteins. This leads to changing the functionality

Antibiotics are amongst the most important medical discoveries and their introduction represents a remarkable success story (Hedin, 2011). The term antibiotics literally means against life (Walsh, 2000). Thus antibiotics can be used against any microbe such as bacteria, viruses, fungi, and protozoa. However, some people use the term to only apply to bacteria, but in this paper, the more appropriate term will be used.

Antibiotic resistance happens when bacteria come into contact with an antibiotic over and over again.

The overconsumption of antibiotics is a big contribution to drug resistance and is why users should know what happens with the repeated use of these drugs. Even though some bacterial mutation occurs naturally, human use of antibacterial is the cause of higher-levels of resistance (Alliance for the Prudent Use of Antibiotics 2014). Bacteria mutate either by genetic mutation or by receiving the defensive agent. During an infection bacteria multiply naturally within the body and when exposed to antibiotics, bacteria have an opportunity to adapt to the drug (Alliance for the Prudent Use of Antibiotics 2014). During this period of

Also known as superbugs, these bugs are resistant to our modern day antibiotics. People around the world are trying to figure out alternatives to this plague. These bugs have evolved over years and years becoming stronger and passing down genes from generation to generation, To slowly become the super bugs that they are known as today. Often these resistant genes are caused by overuse of antibiotics by humans and farm animals, but this is not always true. Recently the ARS (the American Recorder Society) found antibiotic resistance in prairie soils that had no human contact. Antibiotic resistance is commonly viewed as a result of antibiotic overuse in humans and animals, Recently found antibiotic-resistant

As previously discussed, antibiotics often work by targeting critical functions of the bacterial cell. This means that antibiotics have specific targets, which is a boon because it means non-microbial life will not be affected by the antibiotics. However, because of this specificity, bacteria can develop ways of protecting themselves from antibiotics, leading to the rise of antibiotic resistance

Antibiotic resistance is and continues to be a global public health issue1.One of the main concerns stems from the ability for bacteria to obtain antibiotic resistance very easily as a result of chromosomal changes, or through plasmids and transposons which generate an exchange of genetic material2. Resistance can also result from single or multiple mutations1,3. To combat this rising force, scientists must research and analyse the many possibilities of mutations in a variety of genes and proteins in specific bacteria and ways to combat them.

The results of this experiment show that the farms do not share the same plasmid that carries the antibiotic resistance gene. Table one shows the individual group data for the concentration and frequency of the antibiotic resistant bacteria. Table two shows the overall frequency of antibiotic resistant bacteria for code A which was taken from Acme Farm, for the section.

Mutations and genetic evolutions in the bacteria are two ways resistance is growing. These mutations and genetic evolutions get passed down to the next generation, which makes it difficult for scientists to create antibiotics that work each specific strain of bacteria ("Facts about Antibiotic Resistance" 2016). Many resistant antibiotics have targeted the cells by inhibiting the enzymes that usually stop the spread of the bacteria (Diekema 2016). Scientists need to look into preventing these enzymes from getting blocked so the antibiotics can stop the replicating

Antibiotic development is one of the modern marvels of medicine. This is the first external tool that people have to fight against bacterial infections. The first drug developed was Penicillin. This medication is so effective that it is still used today. From its structure, every other antibacterial drug was developed. Today, there are hundreds of options available for treating infections. Unfortunately, this has had significant ramifications on the development of resistance to these medications. As the infections continue to learn and evolve, it is important that people educate themselves on what this means and the impacts it has.

However, microorganisms are now evolving and developing unprecedented resistance to penicillin and other once potent drugs, like

Antibiotic resistance had been a crisis in the United States for many years now. According to the CDC, “up to 50% of the time, antibiotics are not optimally prescribed, often done so when not needed, [or with] incorrect dosing or duration” (CDC). More and more bacteria are becoming antibiotic resistant mostly due to incorrect amount and length of dosage, while sometimes, even the actual antibiotic is incorrectly given to the patient. Because of this, many strains of bacteria had become resistant to these antibiotics and thus, have infected more and more