NHS Histopathology

Decent Essays
Histopathology has played an important role in the understanding of diseases which in turn helps to provide an accurate diagnosis in a timely manner. According to Lord Carter’s review of NHS pathology services (2006 and 2008), pathology accounts for 70% of diagnoses in NHS. Histopathology specimen collection and laboratory techniques vary depending on the clinical spectrum of diseases. The provided services yield tissue morphology and architecture for confirming the diagnosis, monitoring prognosis and determining clinical management since the data provided are essential in choosing appropriate therapies and checking responses to treatment. Advances in biomedical technology and research improve the efficiency of existing services and innovation…show more content…
It is highly important to maintain the original tissue architecture as much as possible during the course of diagnostic procedures. Fixation prevents cellular degradation from lack of blood supply or bacterial putrefaction and preserves soluble proteins by forming cross-linking, thereby protecting them through tissue processing stages (Drury and Wallington, 1980, Eltoum et al., 2001). When fixed specimens are received by the laboratory, creating unique identifying number while cross-checking with the patient profile is essential to prevent misdiagnosis. Standard histopathology procedures include grossing or cutting up, tissue processing, embedding, sectioning, mounting to slides, analysing via microscopes and reporting the diagnosis. Specimens are put into appropriately labelled cassettes and if needed, dissection to thin and uniform slices should be done. Then, the specimen cassettes go through a scheduled tissue processing system, consisting of reagents such as alcohol, xylene or histoclear and paraffin wax. The processed specimens are then moved to embedding station where they are embedded in paraffin using suitable moulds, placed in a correct orientation. Microtomy is crucial to cut
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