Naloxone Essay

Part of this team are pharmacy interns who distribute naloxone (Narcan) rescue kits to the patient every saturday morning. The naloxone rescue kits were donated by the Steve Rummler Hope Foundation. The Steve Rummler Hope Foundation partnered with HCMC with a mission to heighten awareness of the dilemma of chronic pain and the disease of addiction and to improve the associated care process.4 The pharmacy intern spends about fifteen minutes educating the patients on signs and symptoms of opioid overdose, how to respond and how to use the naloxone rescue kits. This program has been successful with distribution of a total of 150 kits as of October of 2016. In addition, patients often provide success stories of occasions when they saved the lives of a loved one or a friend using the naloxone rescue

Last year there were over 64,000 reported opioid-related deaths in the United States – making it the leading cause of accidental death in people under the age of 50 in this country (Katz). Opioids, also referred to as painkillers, have become a growing problem over the past two decades particularly in rural communities all across the country where the death rates are higher per capita compared to the death rate in cities (“America’s Opioid Epidemic is Worsening”). These narcotics, such as codeine, fentanyl, hydrocodone, morphine and oxycodone are extremely addictive and, as a result, this silent killer has quadrupled the overdose death toll since 1999

Naloxone is an opioid antagonist that is designed to rapidly reverse opioid overdose. Take home naloxone programs aim to reduce overdose fatalities by training community members as first responders to opioid overdoses. Opioid users are provided with naloxone

However, this step isn't necessarily to cure the epidemic, but rather to keep it from becoming more catastrophic. This drug is not to be used as away of getting people to stop using opioids in anyway, but rather just keep them from dieing when they do use opioids. Then those who have overdosed can go get help from the types of programs previously mentioned. This is the most important step because it needs to be put into action immediately. If this step takes as long as predicted then the epidemic will only be getting worse and far too many lives will be taken away yet again by opioids. Although, “While DuPage County is the only county currently using intranasal naloxone, Kane, Lake, McHenry and Will Counties are set to implement plans to use both forms of naloxone in the coming months” (Kirk launches suburban anti-heroin task force 1 death every 3 days on average since 2012; using narcan during an overdose was 100% effective in Dupage County, States News

I question are we saving lives with Naloxone or just prolonging it enough until they get a stronger version of heroin or one laced with fentanyl or carfentanyl. Thus, far the effectiveness that Naloxone have on the amount of opioid related overdoses has shown ineffective. The amount of lives saved from Naloxone has increased, however the number of overdoses and deaths have increased in the state of Maryland, since Naloxone has increased on the streets. My audience is for those who set the guidelines for the administration for Naloxone in the State of Maryland. Currently, in Maryland a person does not have to be trained to administer Naloxone. Anyone can go to their local pharmacy to get Naloxone at no cost. There should be more stringent guidelines on how Naloxone is distributed to the community. There should be an increase of education and not a decrease. This is important because educating the community has proven to be an effective intervention for drug use. Administering Naloxone without treatment is keeping people temporarily alive and addicted with the increase of overdoses and deaths in the long-term. Naloxone is reactive and without treatment have been proven ineffective. Naloxone is a short-term solution to

Once more, the lives of Canadians are being claimed by addiction and overdose of a new drug in the streets. For those of you who don’t know what fentanyl is, it’s a powerful opioid, 100 times stronger than morphine, that is often prescribed to help patients manage moderate to severe pain. As a highly addictive substance, many are now dependent on it, and it is one of the most frequent causes of drug overdose. Readily available for purchase online are quantities of pure fentanyl from China, but when improperly diluted in clandestine labs, it can lead to an immediate overdose. Recently, an antidote for opioid overdose called naloxone has become available without prescription, so that anyone can use it. Fentanyl has become a severe problem in the past few years, and while we yet to find a way to eliminate dependence on this drug, we must keep those who use it safe.

Methadone is taken in orally and survives through the digestive system so there is no need to be injected into the patient. It reaches the brain slowly, dampening the “high” that would occur with other routes of administration while also preventing withdrawal symptoms (Heroin, 2014). The advantages of using methadone for heroin addicts are its comparatively low cost and long half-life. According to the Center for Disease Control, methadone helps to restore a degree of normalcy to brain function and behavior, resulting in increased employment rates and lower risk of HIV and other diseases and criminal behavior (Methadone Maintence Treatment, 2002). However, there are a variety of different effective treatments that are available for heroin addiction, including both behavioral therapies and medications. Heroin addicts should be place on less addictive medications like Burenorphine before being placed on Methadone. Buprenorphine, overall, is safer than methadone, and it is easier for an addict to stop buprenorphine than to detox from methadone (Heroin,

Naloxone is an FDA approved overdose reversal medication. Naloxone is a prescription medication that when administered to an individual experiencing an opioid-related overdose restores the individual to consciousness and normal breathing (NAMSDL.org, 2016). Naloxone is always effective when administered correctly (NAMSDL.org, 2016). Since 2000, the drug overdose rate involving opioids has increased 200% (NAMSDL.org, 2016). Treatment centers, physicians and first responders in the rural areas of the United States need more access to naloxone to prevent opioid-related overdose deaths. The U.S Surgeon General Vivek Murthy stated, “People find themselves in overdose situations don’t have to lose their lives because family members or emergency responders don’t have access to the reversal drug naloxone” (Wolf, 2016). Expanding access to rural areas can save lives and prevent deaths.

Today, Naloxone is now being prescribed and dispensed to people at risk of opioid overdose. The number of overdose deaths has quadrupled since 1999. Statistics show that increased availability, relatively low price (compared to prescription opioids), and high purity of heroin in the United States is one of the reasons why death rates are so high. From 2000 to 2015, more than half a million people died from drug overdoses. Every day, approximately 91 Americans die from an opioid overdose. It is a proven fact that most people who are addicted suffer the most overdoses. Anyone taking drugs can suffer an opiate overdose, especially when they take more than prescribed or if they combine opiates with other CNS (Central Nervous System) depressants with alcohol. It's rare for someone to die immediately from an overdose, it's usually a very slow process that takes anywhere from a few minutes to a few hours. After you administer the Naloxone, it lasts between 30-90 minutes before the overdose begins to recur. Also, Naloxone can also cause an uncomfortable withdrawal feeling; This is because it blocks the action of opioids in the

Narcan is an opioid antagonist that reverses the effects of prescription pain medications and heroin. When victims are suffering from an overdose police officers simply spray Narcan up their nose. Within 2-6 minutes the victim should start to breathe again. For some families, giving their son or daughter another chance at life means everything to them while other families feel it is pointless. Many people feel that if all law enforcement is equipped to carry Narcan then drug users will feel they are invincible. Drug addicts don’t use drugs to get to the point of overdose only to be

Vivitrol is an intramuscular, extended-release formula of naltrexone (XR-NTX), which is given once monthly to detoxified opiate dependent patients who wish to abstain from opiate use. Vivitrol is also used to treat alcohol dependent patients, but this paper will focus on its effects on opiate addicted patients. Naltrexone is an opioid receptor antagonist, which blocks the euphoric effects of heroin and prescription opiates by binding to opiate receptors in the brain and blocking the action of the neurotransmitters. The Vivitrol injection releases naltrexone slowly over the course of 4 weeks. The time-release system works by encasing the naltrexone in biodegradable microsphere-polymers, which break down at different rates to maintain therapeutic levels of naltrexone over a 4-week period. Vivitrol suppresses effects such as euphoria, pain relief, sedation, physical tolerance, and physical dependence. This medication, like other extended release injections, is designed to address patient medication-noncompliance. It is recommended that patient have no opiates left in their system for a period of 7 days before starting a Vivitrol regimen. Vivitrol is generally well tolerated with few adverse side effects. One study found the most common side effects to be pain at the injection site, nasopharyngitis, insomnia, and hypertension (Syed, 2013).

If a person has taken opioids and is then given Narcan, the opioids will be knocked out of the opiate receptors in the brain. Narcan can help even if opioids are taken with alcohol or other drugs. According to The Opiate Antidote to Save a Life, “After a dose of Narcan the person should begin to breathe more normally and it will become easier to wake them. Brain damage can occur within only a few minutes of an opioid overdose as the result of a lack of oxygen to the brain.”

3Transdermal delivery of fentanyl has a variety of advantages compared to other delivery systems. Unlike oral administration, transdermal fentanyl avoids first–pass hepatic effect of the liver, which can prematurely metabolize drugs. In comparison with oral opioids, transdermal fentanyl has a lower incidence and impact of adverse effects such as constipation and vomiting, it also enhances patience compliance (as administration is every 72 hours). Transdermal delivery of fentanyl is also more convenient in comparison to hypodermic injection which can be very painful but also exert dangerous medical waste and increase disease transmission with the re use of needles (which is very common in developing countries).

Intramuscular injection is used for the delivery of certain drugs not recommended for other routes of administration, for instance intravenous, oral, or subcutaneous. The intramuscular route offers a faster rate of absorption than the subcutaneous route, and muscle tissue can often hold a larger volume of fluid without discomfort. In contrast, medication injected into muscle tissues is absorbed less rapidly and takes effect more slowly that medication that is injected intravenously. This is favorable

A person’s body, in almost every aspect of its being, is addicted when one is a mild to chronic user and abuser. The nervous system, brain, and muscle tissue are all living in anticipation of the next high. So, for the addict, it is crucial that the cycle of behavior, is broken. The addict needs to pull up the anchor that keeps them from moving forward. This means changing environments, patterns and even sometimes friends and social associates.