Nancy Wexler Research Paper

Huntington’s Disease is a brain disorder affecting movement, cognition, and emotions (Schoenstadt). It is a genetic disorder generally affecting people in their middle 30s and 40s (Sheth). Worldwide, Huntington’s disease (affects between 3-7 per 100,000 people of European ancestry (Schoenstadt). In the United States alone, 1 in every 30,000 people has Huntington’s disease (Genetic Learning Center). Huntington’s Disease is a multi-faceted disease, with a complex inheritance pattern and a wide range of symptoms. There is also much research being done in the field of Huntington’s disease, because as of 2012, this disease is untreatable. THESIS.

Huntington’s disease destroys the organs that carry the functions of the central nervous system. Kalat (2013) states, “Huntington disease (also known as Huntington disease or Huntington’s Chorea) is a severe neurological disorder that strikes about 1 person in 10,000 in the United States” (A.B. Young, 1995, p. 258).Individual’s develop the symptoms in their middle age, but even if it is a rare disorders juveniles as well as children before the age of ten can develop the disease. Huntington’s disease is hereditary disease that is passed on from a parent. Huntington’s disease is of the lack of the chromosome 4, if one of the parents carries the gene, they can pass that gene to their

Huntington's Disease (HD) is an autosomal dominant, progressive, neurodegenerative disorder (Walker, 2007 and Harmon, 2007). The gene that causes the disease is located on the fourth chromosome and causes an abnormal number of repeats in the patient's genetic code (Harmon, 2007). Huntington's Disease can have devastating effects on patients' quality of life. The first symptoms of HD generally start between the ages of 30 and 45 and patients are typically asymptomatic prior to this time (Terrenoire, 1992 and Walker, 2007). However, the disease progresses with subtle changes in motor control, personality, and cognition. Patients eventually develop distinct

It is a disease that progressively breaks down the nerves in the brain. The genetic mutation that underlies the disease is in chromosome 4. The gene codes for the huntingtin protein, which makes up about 6% of the DNA in cells (Genetic Home Reference). This mutation deals with the trinucleotide repeat of the cytosine-adenine-guanine (CAG) sequence. This sequence repeat can repeat up to 40 times to be considered normal, but after this sequence repeats more than 41 times then it is considered Huntington's disease. Huntington’s protein can form inclusions seen in both the cytoplasm and the nucleus (Suchowersky). These inclusions are correlated with neuronal cell death, which occurs within the nerves. Interestingly, Huntington protein seems to be very important for early development (Suchowersky), but in high concentrations appears to become toxic especially to nerve cells. Overall, Huntington’s disease has a very intense effect on the body and behavior

Huntington disease is defined by the autosomal pattern that is in inheritance with high penetrance of high proportion of the population that has the gene that advances the disease. It’s typical that Huntington disease is caused by the loss of neurons nerve cells in the brain (Van Walsem M.R, 2016).

Huntington’s disease affects 30,000 Americans and has 200,000 more Americans at risk to contract the disease. Huntington’s is now one of the most common brain disorders to be inherited. This paper will discuss and educate about the disease, pathology, signs and symptoms, etiology, prevalence, diagnostic studies, treatments, and the prognosis of Huntington’s disease.

Imagine not remembering the names of your family members, having difficulty swallowing, not being able to control your movements. Imagine being trapped in a body that is turning against you, slowly deteriorating around you and you are helpless to stop it. This is the very real and terrifying reality for those with Huntington’s disease. “Many describe the symptoms of HD as having ALS, Parkinson’s and Alzheimer’s – simultaneously.” This disease isn’t picky, it devastates the families of people from all races or ethnic groups around the world, and a person’s sex isn’t an issue. “Huntington’s disease is a fatal genetic disorder that causes the progressive breakdown of nerve cells in the brain.” This disease is passed from

Huntington 's disease is an inherited neurodegenerative disease that is caused by a mutation on the HTT gene. It typically effects persons in their third to fifth decade of life and can be passed onto their children. Neurons in the brain waste away or degenerate in different areas causing the characterizing symptoms, such as dance-like movements and mental decline. Diagnosis and prognosis can be devastating to both individual and family. However, there are genetic tests that can help to predict the probability of developing symptoms of the disease. There is no cure for this debilitating disease; only symptom control and maximization of comfort can be prescribed until future research finds a cure. This paper will review origins and symptoms, in addition to treatments and future treatments.

Huntington’s disease is a progressive neurodegenerative disease that causes uncontrolled physical movements and mental deterioration. Huntington’s destroys the brain leading to changes in personality and even cognitive functioning. A faulty gene is responsible for this disease. This faulty gene generates a malformed protein which is accountable for the immediate damage. This damage leads to a slow decline and eventually death. Unfortunately there is no cure and only minor treatments to manage

For our gene and protein lab, my group decided and I to research the deadly, yet rare, disease, known as Huntington's disease. Huntington's disease is an extremely rare condition when your nerve cells in your brain break down overtime. Also, “HD” has a treatment that could aid someone, but it unfortunately cannot be cured. Huntington’s Disease typically begins when someone is thirty or forty years of age and can last years to a life time.

Huntington’s disease is a fatal genetic disorder that causes the progressive breakdown of nerve cells in the brain and eventually causes death. It is caused by a mutation in a gene that is responsible for producing the huntingtin protein. Over a period of time, physical and mental abilities gradually deteriorate, and there is currently

Huntington’s disease (HD) is a late-onset, usually between 35 and 50 years old, neurodegenerative disorder prevalent in 3-7 per 100,000 people of European ancestry1. The disease, inherited in an autosomal dominant pattern2, is characterized by motor disturbance, intellectual decline, and psychiatric manifestations3. The disease is difficult to detect at an early stage of an individual’s life since its symptoms appear in the third to fifth decade of life. To better understand the disease, investigations were done to identify the gene that is linked with the disease. The researchers in this paper relied on the polymorphic protein markers or enzymes which they excluded in the 20% of the genome. However, the lack of additional markers made it impossible to test the remaining part of the genome.

Huntington’s disease is caused by the mispelling in the HTT gene for a huntingtin protein. Involved in the HTT mutation that causes Hungtington’s disease, the CAG trinucleotide

Huntington’s Disease (HD) is a genetically inherited, progressive, autosomal dominant, fatal neurodegenerative disease that’s characterized by behavioral difficulties, decline of cognitive abilities, abnormal involuntary movements (chorea), and muscle spasms (dystonia) (1). These characteristics help diagnose patients with HD, but a genetic test can be done to prove that one has the disorder. The gene responsible is that which produces the huntingtin protein in chromosome 4; the defect causes extra repeats of the chemical code (2).

Huntington disease is a destructive brain disorder for which there are currently no cure. Some medications have been proven to ease symptoms of the disease including Tetrabenazine which is a medication which helps conceal the uncontrollable jerking and writhing movements. The most promising approach to curing Huntington disease is developing drugs that would tell our cells to make less of the damaging Huntington protein. Scientist are on the verge of using gene therapy to correct the mistakes in our DNA causing Huntington disease.