Naturally Occurring T Regulatory Cells, Interleukins 10 and 12 in the Pathogenesis of Idiopathic Warm Autoimmune Hemolytic Anemia.

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ABSTRACT There is now compelling evidence from animal models autoimmune hemolytic anemia (AIHA) that naturally occurring regulatory T cells (n-Tregs) play an important role in immunologic tolerance and control of immune-mediated pathology. However their study in human AIHA is still ill defined. Aim: To measure the peripheral blood proportions of n-Treg cells and the levels of IL10 and IL12 in basal and mitogen-induced (Lipopolysaccharide, LPS) cultures of PBMCs in patients with idiopathic warm AIHA (wAIHA) in a trial to ravel out some enigmatic aspects in the pathogenesis of this autoimmune disorder. Patients&Methods: This study included 27 patients with idiopathic wAIHA, 9 males and 18 females with male/female ratio 1/1.5. Their ages …show more content…
There was a statistically negative correlation between n-Tregs percent and IL10b&IL10LPS, p<0.05. There was a statistically positive correlation between IL10b&IL10LPS and RC, p<0.001, while there was a statistically negative correlation with Hp, p<0.01 and p<0.05 respectively. Conclusion: Although there may be multiple factors that contribute to the induction of warm AIHA, our data indicate that defective suppressive activity of n-Treg cells and IL10/IL12 imbalance could play an essential role in the onset and/or maintenance of this autoimmune disease. Further investigations in 1ry AIHA syndrome in which autoimmunity is a significant feature, holds the promise of identifying new molecular defects that will further elucidate basic mechanisms of self tolerance and provide new targets for therapy.

Keywords: Autoimmune hemolytic anemia; regulatory T cells; Interleukin10; Interleukin12.

INTRODUCTION Warm autoimmune hemolytic anemia (wAIHA) accounts for about 50-70% of cases of autoimmune hemolytic anemia and is characterized by the production of autoantibodies (autoAbs) that target determinants on red blood cells(1). These antibodies are typically of polyclonal origin, belong to the IgG isotype, and arise idiopathically or in the context of lymphoproliferative disorders or autoimmune diseases (AD). IgG-coated RBCs undergo accelerated Fc gamma

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