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Ncldv Virus Research Paper

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In the last two-decade, numbers of giant dsDNA, icosahedral viruses have been discovered and assigned to the NCLDV clade. The major capsid proteins of these viruses consist of two consecutive jelly-roll domains, assembled into trimers, with six fold symmetry. The capsomers are assembled into arrays that have either p6 as in Paramecium bursaria Chlorella virus 1 or p3 symmetry as in Mimivirus (Xiao & Rossmann 2011).
Mimivirus has a capsid (icosahedral) diameter of 400 nm with protein filaments of 100 nm from the surface of the capsid, comprising the total length of the virus up to 600 nm. While most of the other discovered large viruses size varies between 400 nm and 800 nm (Xiao et al., 2009). Mimivirus shares similar morphological characteristics with all members of the NCLDV group of viruses. The central core of the virion appears as a dark region under the electron microscope. An internal lipid layer surrounding the central core seen in all other NCLDV viruses this features present in Mimivirus (Xiao et al., 2009).
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However, the virions of P. sibericum like pandoraviruses morphologically but are still being the largest (1.5 μm in length), with a 60 nm thickness of the enveloped hexagonal structure that missing in pandoraviruses. Pandoravirus and P. sibericum both have the apical pore. Wile, the virion of M. sibericum is a spheric shape covered with 2 to 4 layers of fibers. Faustovirus virions have an icosahedral capsid without fibers. As for virions of all previous giant viruses, the internal lipid membrane surrounding the core and fuses with the vacuole membrane is to release the dsDNA
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