Neoplasia

(p133-134, text). * Define metastasis. * Development of a secondary tumor in a location distant from the primary tumor. * Accomplished via lymphatic channels and circulation. * Trace the pathways for the hematologic and lymphatic spread of metastatic cancer cells. Evidence of disseminate disease presence in lymph that drain the tumor area, tumor cells lodge first in the initial lymph node that receives drainage from the tumor site, once in this lymph node cells may die b/c of the lack of a proper environment, remain dormant for unknown reasons, or grow in a discernible mass, If they survive and grow cancer cells, may spread from more distant lymph nodes to the thoracic duct, and the gain access to the blood vasculature, cancer cells may gain access to the blood vasculature from the initial node and more distant lymph nodes by way of tumor-associated blood vessels that may infiltrate the tumor mass. Sentinel

Cancer, medically called ‘tumorigenesis’ (Thaker, Lutgendorf, & Sood, 2007, p.430) occurs when cells in the body orient themselves for malignant growth. Such cells show ‘self-sufficiency in growth signals’, are ‘insensitive to anti-growth signals’ and have ‘limitless replicative potential’ (Thaker, Lutgendorf, & Sood, 2007, p.430). Once a particular set of cells become malignant, the malignancy can spread to other set of cells in different organs due to ‘crosstalk’ between the affected cells and their surrounding ‘tissues’ and ‘micro-environments’(Thaker, Lutgendorf, & Sood, 2007, p.430).

Tis means that the cancer cells are only growing in the most superficial layer of tissue, without growing into deeper tissues. This is also known as in situ cancer or pre-cancer.

“Cancer is a term used for diseases in which abnormal cells divide without control and are able to invade other tissues. Cancer cells can spread to other parts of the body through the blood and lymph systems (NCI, 2013).” Cancer is of many diseases. It originates from the organ in the body and/or from the part of the body that is affected, for example breast cancer. Breast cancer is mainly common among women, except for skin cancers. “Breast cancer occurs when cells in the breast divide and grow without their normal control (Komen, 2014).” The

When cancer develops, it typically forms in one part of the body. This site is known as the primary site. Unlike other cells in the body, cancer cells can break away from the primary site and travel to other parts o...

There are two extensive classes into which all malignancy types can be isolated: hematological, which are blood-borne diseases and strong tumors, which are the developments depicted previously. Every kind of disease has an extraordinary name, more often than not originating from the range of the body which is fundamentally influenced. For instance, delicate tissue tumors are dangerous developments which happen inside the profound muscle or interfacing tissues all through the body. Melanoma is a sort of skin growth, which influences cells containing skin pigments.

Cancer is defined by the National Cancer Institute as the title given to a group of related diseases. All types of cancer are categorized by uncontrollable growth of cells that metastasize to surrounding tissues. Cancer can develop at almost any part of the human body and anyone can develop cancer, although risk typically increases with age because most cancers tend to require many years to develop. ?Typically, human cells tend to grow and divide and ultimately form new cells as the body needs them. When an organisms cells grow old or get damaged, the cells die, and new ones replace them. However when cancer develops, this orderly process gets reformatted. As cells increasingly get more irregular, old or damaged cells begin to survive when they should die, and new cells develop in the body when there is no need for them. These abnormal cells have the ability to divide without stopping and tend to result in growths called tumors?(cancer.gov). Cancerous tumors are defined as malignant meaning that they can spread to nearby tissues or metastasize to distant places in places within the body and form new cancerous tumors. There are over 100 forms of cancer and they are usually named after the organs or tissues where the cancers originate. Staging of cancer is used when describing the severity of a person?s cancer and is based upon the following

the American Cancer Society there are benign tumors, which are rare and often develop in

Cancer is a very general term that can refer to many different diseases. The different major classifications of cancer are Carcinoma, Leukemia, Myeloma, Lymphoma, and Sarcoma. Carcinoma is a cancer of the external or internal linings of the body such as epithelial tissue. Leukemia is a cancer of the bone marrow. This is also known as blood cancer, because bone marrow is the site where blood cells are produced. Myeloma is a cancer found specifically in the plasma cells of bone marrow. Lymphoma is a cancer that develops in the lymphatic system. The cancer appears in the nodes, glands,

Solid tumors can be either malignant or benign. Malignant solid tumors are cancerous, while benign solid tumors are not. The names of solid tumors vary depending on the cells or tissues that from them. Examples of solid tumors include sarcomas (connective tissues e.g. fat cells, muscles, nerves, tendons etc), carcinomas (begin in tissues that lines the internal surface of the body and body organs e.g. breast, lung, prostrate, and colon), Lymphomas (affects the immune system).

Breast cancer is a disease in which malignant cells form in the breast tissue. There are many different kinds of breast cancer, which is determined by which cells in the breast that are cancerous. The lobules, ducts, and connective tissue are the three main parts that make up the breast. Most cancer starts in the ducts and lobules with the most common being invasive ductal carcinoma and invasive lobular carcinoma. In invasive ductal the cancer cells grow outside the ducts of the breast into other parts of the breast tissue and may metastasize to other parts of the body. Invasive lobular cancer starts in the lobules of the breast and spreads to the nearby breast tissue or other parts of the body.

Malignant tumors are harmful to the body and need immediate action. They have an absence of a border and metastasize by growing in different parts of the body once they have traveled throughout the vascular system.

There are a wide variety of cancer types. They all have several things in common, however. Each cancer starts with cells that become abnormal or cancerous. These cells reproduce and form a mass of cancerous cells. This mass is called a tumor. When the cancerous cells spread, or metastasize, they can impact other tissues, organs, and systems of the body. A second commonality among cancers is that when they are detected early, they are easier to treat and the treatments are more likely to work. In many cases, a cancer that is caught early can be completely destroyed.

This ability of malign cancer to make their way across basement membrane and into blood vessels is what makes cancer so fatal and impossible to be cure by surgery alone. The result of metastasis and invasion in normal tissue by cancer cells are often seen as one of the distinctive features of malignancy (Ruoslahti 1996). Even though the ability of invasion and metastasis are one of the hallmarks for cancer, these abilities are not unique to cancer cells as it can also occur during the early development stage of the embryo, in healthy organisms and in many noncancerous diseases (Mareel & Leroy 2003). It does not matter whenever the organism has developed benign or malign cancer, all cancer cells have the ability to disturb the normal cell cycle and threaten the survival of the organism.

Tumors are one of the most feared diseases of our time. Many people upon hearing the word “tumor” immediately resonate to the conclusion of it being cancer, which is not necessarily true. Tumors fall into to two main types, benign and malignant. Although they are considerably different in tissue invasion, their nature that makes them distinct and symptoms, they are also quite similar in the way they recur in the same location, growth size and their health risks.