Neuro-Oncology

A person has a 0.55–0.7% chance of developing any type of brain tumor in their lifetime (Mohammadi and Schroeder 1). A brain tumor is a mass of abnormal cells located somewhere in the brain. Brain tumors can be caused by many different disorders including Tuberous Sclerosis Complex (TSC). Some tumors caused by this disorder are inoperable. Inoperable brain tumors can now be treated using new advanced technology. Technological advances provide new hope for patients who have inoperable brain tumors and TSC.

Once a person has been diagnosed with brain cancer, treatment should begin immediately. Treatment for brain tumors involves any combination of surgery, radiation, and chemotherapy. Some tumors require several different surgical procedures; some can be treated with radiation alone. Surgery is the best process to remove a brain tumor. Surgery attempts to remove most, if not all of the tumor. Once most of the tumor is removed, the rest of the tumor can be removed through a process called radiotherapy.

Glioblastoma is the most common and aggressive form of malignant brain cancer in adults. On average, 8 of every 100,000 people in the U.S. are diagnosed with glioblastoma every year – representing approximately 2% of all cancers diagnosed [1]. Glioblastoma tumors form when astrocytes, star-shaped cells which support and protect the brain, re-enter the cell cycle and start to rapidly divide. Because the brain is supported by a large network of blood vessels, tumors grow quickly and are difficult to remove surgically. Present treatments for glioblastoma are limited to surgery, radiation therapy, and chemotherapy; however, despite these interventions tumors are likely to regrow. Consequently, typical survival time following glioblastoma diagnosis is less than 2 years.

Glioblastoma (pronounced like gleO blastoma) is an incurable brain cancer,Survival rate is usually measured in months.This became a word that was instantly defined, researched, dissected, feared, and tried to comprehend and understand by family,friends and acquaintances of Larry McKee (McKee)who was personally affected from this single word, it was quickly added to their vocabulary, because of the of the events that transpired on October 22, 2011 that forever changed lives “Glioblastomas are tumors that arise from the astrocytes- the star-shaped cells that make up the “glue-like,” or supportive tissue of the brain. These tumors are usually highly malignant (cancerous) because the cells reproduce quickly and they are supported by a large network of blood vessels.”(A.B.T A..) He was diagnosed with stage four.

The primary ones include these types. Gliomas, the most common brain tumor involving the brain tissue. There are different grades and even types of gliomas. But if the tumor grade is higher, it will probably grow faster. Medullblastomas are brain tumors that in young children. Without treatment it will spread rapidly into the spinal fluid and other parts of the brain. But almost or half of the brain tumors found are benign. These types of brain tumors are usually Meningiomas and Neuromas. Meningiomas begin in the tissue membranes. Neuromas are in the nerves mostly in people over

Tumors can be classified into three types: 1) benign 2) pre malignant 3) malignant tumor. Benign tumors are those which are incapable of abrupt expanding and affecting the other healthy brain tissues. Premalignant tumor is a pre cancerous stage, if not treated properly it may lead to cancers. It is often considered as a disease. Malignant tumor grows rapidly with time an ultimately leads to death of patient. Malignant is a medical term describing a sever growth of a disease. The most common primary brain Tumors are gliomas, wherein 70% are in the group of malignant gliomas, glioblastoma multiform (GBM).The GBM is one of the highest malignant human

Glioma is a tumor that is a type of brain cancer. Glioma tumors are made up by cells called glial cells. Glial cells normally provide nutrition, oxygen, and structural support to the brain. Three types of glial cells can produce tumors. Gliomas are named after the type of glial cell that is involved in the tumor. A tumor is formed when the glial cells grow into an abnormal mass of tissue. Gliomas are one of the most common types of brain tumors that occur in adults.

Treatment and prognosis of cerebral gliomas vary depending on their grading. To date, histological evidence provided by biopsy is the gold standard for grading of gliomas. Development of diagnostic neuroimaging methods for non-invasive differentiation of high and low grade tumors is extremely desirable.

An Intracranial tumor is an irregular group of brain tissue in which cells widen and cultivate intractably, which effects the means to control normal cells. Intracranial tumors situated in the frontal lobe are quite natural since this lobe is the biggest in the brain. These growths are categorized as primary, which means they start out in the brain (benign), or secondary, meaning they have a different starting location in the body and spread to the brain (metastasized). Primary tumors tend

CNS tumors represent the second most frequent tumor of childhood and the most common pediatric solid tumor; approximately 2,200 patients under the age of 20 are diagnosed each year with invasive CNS tumors, and CNS tumors are the number one cause of death from childhood cancer. [1] Therapeutic strategies generally involve surgery as a primary intervention, but complete resection is often not possible due to tumor location. In such cases, adjunct therapies, including chemotherapy and radiation therapy, may be required based on the tumor histology and presence of residual tumor. [2]

Ependymoma is a type of brain tumor and while it is rare in adults, accounting for 2-3% of brain tumors, ependymoma is mainly found in children and accounts for around 5% of all childhood brain cancers (American Cancer Society [ACS], 2014, January 31; American Brain Tumor Association [ABTA], n.d.). The survival rate of patients with ependymoma who have survived five years after their tumor is detected is 75% Tumors occur when cells grow to excess and form a mass. While some tumors are benign, meaning that they are harmless, others are malignant, or cancerous. Ependymoma is a malignant cancerous brain tumor (“American Society of Clinical Oncology [ASCO]– Childhood,” n.d.). The tumor appears as soft, grey or red tumors and could comprise of cysts or mineral calcifications.

The diseases associated with FUBP1 include oligodendrogliomas, astrocytomas, and oligoastrocytomas. Oligodendrogliomas are primary glial brain tumors and can be either low-grade (grade II) or high-grade (grade III). [2] Since oligodendrogliomas have a slow growth rate, they are often present for years before they are diagnosed. Nevertheless, the most common symptoms include: seizures, headaches, and personality changes. Altogether, the symptoms vary by location and size of the tumor. About 66 to 78 % of people with grade II oligodendroglioma survive for about 5 years after diagnoses, while 30 to 38 % of people with grade III will survive for about 5 years after they are diagnosed. [3] Astrocytoma is another type of brain cancer that stats in the cerebrum, which is the largest part of the brain, but can also appear in the cerebellum, which is the back of the brain. It is more common in men than in women. Like oligodendrogliomas, the most common symptoms of astrocytomas include: headaches, seizure, changes in behavior and memory loss. [4] Prognosis of astrocytomas depends on the type of astrocytoma. Altogether, a low-grade astrocytoma (LGA) has an 83 % 10-year overall survival, while the overall survival rate of a high-grade astrocytoma (HGA) range between 15-20%. In both oligodendrogliomas and astrocytomas, the FUBP1 locus is mutated which leads to the inactivation of

Current investigations indicate that Central neurocytoma could be of astrocytic origin or mixed lineages. Immunohistochemical tests shows multiple positive markers of neural cell that includes synaptophysin, neuron specific enolase, neuronal specific nuclear protein , and neuron specific class III beta tubulin. In addition to dense core vesicles and parallel microtubules are present in pathology. The tumor also shows positive neurofilament (NF) staining but some of the Central Neurocytoma fails to show consistent pathology. Unfortunately, the Immunohistochemical studies are not specific to draw a concrete conclusion to the origin of neurocytoma. Von Deimling et al. investigation indicated that Central neurocytoma shows glial fibrillary acidic protein (GFAP) and Syn, which is related to reactive astrocytes. Other studies were unable to attain the same results. In vitro, the tumor cells tend to become glial cells regardless of the medium of the culture. In vivo, the origin of the cells is not clear. Some researches hypothesize that CN arise from neural stem cells surrounding the ventricle zones. This hypothesize was based on high levels of choline, cholinergic receptors, gamma-aminobutyric acid, and normal or low levels of glutamate and catecholamines. Kim et al also showed the presence of Musashi-1, and the neuroep- ithelial enhancer gene nestin. These results point towards possible genetic properties to

-The complete removal of some brain tumors- A sample to enable doctors to diagnosis the tumor and recommend the most appropriate treatment

Common malignant brain cancers increase significantly according to statistical data collected by the National Cancer Institute. In 1984, the annual incidence rates of primary brain tumor and primary brain lymphoma also increased notably, the rate of lymphoma almost tripling,