Neurodegenerative Disease Analysis

Alzheimer disease (AD) is the most common cause of dementia in the elderly, accounting for 65–70% of all cases (Jellinger, Janetzky, Attems, & Kienzl, 2008). The other dementias are of the Parkinson 's group, the fronto-temporal group and the vascular group. The total worldwide yearly costs for the treatment and care of patients suffering from dementia are estimated to be around 250 billion US dollars. The lifetime risk for AD between the ages of 65 and 100 is 33% for men and 45% for women with an annual increase of 1–2% in the seventh decade to almost 60% in the 10th decade with doubling every 5 years (Jellinger et al., 2008). AD is incurable, and thus represents a major public health problem. AD represents a challenge to humanity due to its relatively recent discovery, progressive nature of the illness, and complex diagnosis.

Alzheimer 's disease (AD) is a progressive degenerative disease of the brain from which there is no recovery. There are three brain abnormalities that are the hallmarks of the Alzheimer’s disease is initially caused by plaques buildup in the brain’s neurons as illustrated in figure 1. The support structure that allows the flow of the nutrients through the neurons gets damaged and ultimately there is loss of connection among the neurons and they die off (National Institute of Health, 2015). This causes the brain tissue to shrinks, which is called atrophies. All this ultimately lead the victim of this disease to face difficulties in governing emotions, recognize errors and patterns, coordinate movement, and remember. Ultimately, a person with AD loses all memory and mental functioning.

Alzheimer’s disease is a prominent brain disease that effects a massive amount of individuals in the United States. Alzheimer’s disease (AD) is the sixth leading cause of death in the United States, accounting for 60-80% of dementia cases, with no chance of being cured, prevented or decelerating over time (Alzheimer’s Association, 2014). AD is the most well-known form of dementia, causing complications in brain function in the areas of memory, thinking, and behavior (Alzheimer’s Association, 2014). In an effort to gain a deeper understanding of Alzheimer’s disease, researchers create new knowledge about the disease, which is then distributed to the public. The goal in this information disbursement is to find new and inventive ways to treat AD, prevent AD from progressing at such a rapid pace, and aid in the quality of life in those diagnosed with AD as well as caregivers and medical professionals providing treatment to individuals’ with AD.

Alzheimer’s disease is a complex illness that affects the brain tissue directly and undergoes gradual memory and behavioral changes which makes it difficult to diagnose. It is known to be the most common form of dementia and is irreversible. Over four million older Americans have Alzheimer’s, and that number is expected to triple in the next twenty years as more people live into their eighties and nineties. (Johnson, 1989). There is still no cure for Alzheimer’s but throughout the past few years a lot of progress has been made.

Alzheimer's is a type of dementia that causes problems with memory, thinking and behavior. It is the most common form of Dementia which is a general term for a decline in mental ability severe enough to interfere with daily life. Alzheimer’s accounts for 60-80% of dementia cases. Based on 2018 Alzheimer’s Association statistics, there are more than 5 million Americans living with Alzheimer’s over the age of 65 (Alzheimer’s Association, 2018). Many scientists state the death rate for heart disease has declined by 11% while death by Alzheimer’s has raised by 123% (Alzheimer’s Association, 2018). It is considered to be the 6th leading cause of death in the United States (Alzheimer’s Association, 2018). Alzheimer’s disease(AD) is an abnormal aging

Alzheimer’s disease, considered the most common form of dementia, is a degenerative brain disorder which leads to loss of memory and decline of cognitive thinking. Alzheimer’s disease effects over 5 million Americans, a number which is expected to triple in the projected future, and is the sixth leading cause of death in the United States (Dougherty, R.J., et al). Majority of these affected people are sixty-five years of age or older and have what is called late-onset Alzheimer’s, whilst a smaller margin of individuals is younger than sixty-five years of age and are said to have early-onset Alzheimer’s. Alzheimer’s disease presents itself in three main stages, is caused by the degeneration of neurons and by the changes in protein composition in the brain, and despite the lack of definitive, early diagnosis or preventative treatment the disease can to a certain degree be detected and managed.

Alzheimer’s is an irreversible disease normally affecting the elderly population and is progressive in nature causing degeneration that leads to impairments in memory, reasoning, planning, and behaviour. It is a neurodegenerative disorder that adversely affects neurons in the brain, ultimately resulting in loss of memory and language, behavioural disturbances, and dependence on caregivers (Phillips, Baktir, Das, Lin & Salehi, 2015, p. 1047). Alzheimer’s has 3

The alzheimer’s disease is a progressive disease that destroys memory and other important mental functions. Alzheimer's is not a normal part of aging and only up to 5 percent of people with the disease have early onset Alzheimer's (also known as younger-onset), which often appears when someone is in their 40s or 50s. This disease doesn’t have a cure, but there are treatments for symptoms available and research still continues to find the answer to cure this bad disease. Also, an interesting fact is that ninety percent of what we know about Alzheimer's has been discovered in the last 15 years. Lastly, Alzheimer's is a progressive disease, where dementia symptoms gradually worsen over a number of years. In its early stages, memory loss is mild, but with late-stage Alzheimer's, individuals lose the ability to carry on a conversation and respond to their environment. It’s the sixth leading cause of death in the United

Alzheimer’s disease or also known as Alzheimer’s is the neurodegenerative most common type of dementia that usually commences in older people; this is a very complex brain disorder that interferes with the affected individual’s life as soon as it initiates its mission of destroying the brain, it progresses slowly and gets worse over time from mild forgetfulness to brain impairment. Furthermore, scientist do not fully understand what causes this irreversible disease that has no cure or prevention and it may be inherited. Alzheimer’s disease seems to be caused by unusual plaques (beta-amyloid) and tangles in the brain, damaging important areas of memory and learning (Hanyu et al., 2010), together with, dementia is defined as a loss of mental

Alzheimer’s Disease (AD) is a progressive and neurodegenerative form of dementia that causes problems with memory, thinking, reasoning, judgement and decision-making, recognizing, as well as behavior, and is serious enough to interfere with daily life and activities, that eventually leads to profound physical as well as mental disabilities, resulting in the need for institutional care (Hoyer & Roodin, 2009). AD is most widespread in senior population aged 65 and over, which constitutes approximately 85-95% of the cases, in the rest of 5-15% of the times Alzheimer’s Disease can have an early-onset (before 60 years of age) (Hoyer & Roodin, 2009). According to Alzheimer’s Association, today Alzheimer’s Disease is at the forefront of biomedical research, as it is the sixth leading cause of death in the United States (alz.org). Researchers hope that better understanding of Alzheimer’s and related dementias can lead to discovering new and effective treatments. United States is not the only country that is facing this issue, this problem is global. According to the recent epidemiological studies, the worldwide prevalence of Alzheimer’s Disease will rise from 27 million people worldwide in 2006 to 66 million in 2030, and 115 million in 2050 (Werner, 2012). The main risk factor for developing AD is chronological age (Hoyer & Roodin, 2009). This means that by 2050, one in three persons over 80 years of age will most likely suffer from some sort of dementia, most likely from AD

Alzheimer’s disease is among the sixth top leading causes of death in the United States and even with an estimated 4.5 to 5.4 million suffering from Alzheimer’s disease (AD) not much is known about the causes. Only the symptoms are addressed. The main characteristics of AD are degeneration of the ability to remember, reason, communicate and with loss of motor skills and function (Piazza-Gardner, 2013). Cognitive function that is lost and is accompanied by other physiological conditions such as depression, anxiety, irritability, aggression and inappropriate behavior for a setting or location that occur in most AD suffers (Senie, 2014). AD was noted as abnormal clumps and a bundle of proteins in the brain which was discover in patients with

Alzheimer's disease is a retrogressive disease that affects the cognitive abilities of individual, and functions of tissues and organs. It has many deficits and symptoms that slowly weaken the mental functioning of the individuals and destabilize their social relationships (Brandao, Castello, Van Dijik, Parente, and Casanova, 2009).

Alzheimer’s disease (AD) is the most prevalent neurodegenerative disorder and the leading cause of dementia in people above the age of 65. In 1901, Alois Alzheimer identified the first case of this disease and discovered the pathological condition of dementia that bears his name. AD is a progressive disease, the most common early symptom is short-term memory loss. As the disorder advances, individuals have problems with language, motivation, mood and long-term memory. In the final stages, the patient is complete loss of daily living activities.

Also, along with Alzheimer’s, there are other diseases such as Parkinson’s which show no improvement and are a huge liability to the health care system. A lot of research is ongoing since ages but no drug is so far available which can cure such a disease. AD occurs due to progressive loss of the neural cells, which causes loss of memory, which might end up as fatal. Recent advances in the research have found the AD occurs to loss of mitochondrial function and mis-folded proteins. Currently six drugs have been approved in the United states for AD. All the drugs have shown moderate improvement in behavioral and functional measures in the

Alzheimer’s disease is a devastating genetic disease that ravages the brain, destroying its tissues and altogether its ability to function. It is not sure exactly how it is caused, although it is known that the disease is genetic and is the result of a dominant allele on a chromosome and that certain lifestyle factors such as foods consumed and exercising can slow the disease’s spread. The disease itself is very progressive as it can take many years to even be seen after it first begins and people with the disease usually live about eight years after they see the first symptoms on average.