Neurofibromatosis (NF) Type I

3146 Words13 Pages
Introduction
Neurofibromatosis (NF) Type I is a common autosomal dominant genetic disorders. NF Type I has a prevalence rate of approximately 1/3000-4000 individuals. NF Type I is caused mutations in the NFI gene. This gene provides instructions for making the protein neurofibromin. Neurofibromin is produced in many cells, including nerve cells and specialized cells that surround nerves such as, oligodendrocytes and Schwann cells. This protein acts as a tumor suppressor that keeps cells from growing and dividing too rapidly. Mutations in the NFI gene lead to the production of a nonfunctional version of neurofibromin that cannot regulate cell growth and division. Therefore, tumors can form along the nerves throughout the body due to the mutation.
…show more content…
Linear regressions were also conducted in order to truly determine whether mental development and productive vocabulary at T1 or T2 was a good predictor of intellect and language outcomes at T3 Lorenzo et al. (2015). The results of this study found that children with NF Type I had a significant difference in their cognitive scores as compared to their controls. However, parental reports did not indicate any significant group differences in behavior from T1 to T2 to T3. The findings of this study also supported the hypothesis that earlier mental function is a significant predictor of later intelligence. Lastly, the findings of this study also supported the hypothesis that early productive vocabulary is a significant predictor of later language skills (Lorenzo et al.,…show more content…
Lehtonen, Howie, Trump, and Huson (2012) conducted a systematic review of the literature in order to identify and further study the behavioral systems and attentions of children with NF Type I. Lehtonen et al. (2012) examined empirical studies of children with NF Type I who ranged in age from 6 to 16 years and used electronic resources such as MEDLINE, PsycINFO, and EMBASE as search engines. A total of 57 research studies met their inclusion criteria and data found from the studies was synthesized using the narrative

More about Neurofibromatosis (NF) Type I

Get Access