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Neurogenesis: A Therapeutic Analysis

Decent Essays

Adult neurogenesis involves persistent proliferative neuroprogenitor populations that reside within distinct regions of the adult brain. This phenomenon was first described over 50 years ago and it is now firmly established that new neurons are continually generated in distinct regions of the adult brain. The potential of the neurogenesis process lies in improved brain cognition and neuronal plasticity particularly in the context of neuronal injury, neurodegenerative disorders. In addition, adult neurogenesis might also play a role in mood and affective disorders. The factors that regulate adult neurogenesis have been broadly studied; however, the underlying molecular mechanisms of regulating neurogenesis are still not fully defined. Here we discuss the current understanding of these factors and provide a critical analysis of the molecular …show more content…

We will further discuss the pre-clinical and clinical studies testing the potential in which the modulation of these factors could be used for therapeutic applications in neurodegeneration.
Keywords: niche, neurotrophins, cytokines, transcription factors, stem cells, extrinsic factors, and therapy.
Background
Neurogenesis is an endogenous process that involves coordinated proliferation, differentiation, and migration of neural precursor cells [1]. It determines brain formation during embryonic development, but persists in localized regions of the adult brain or neurogenic niches. As a result of aging, brain injury, genetic mutations and a number of other factors, the progressive loss of structure, function, and depletion of neural precursors may contribute to neurodegenerative disorders including Alzheimer’s disease (AD) and Parkinson’s

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