New N Substituted Pyrazoline Derivatives

8. ISBN: 0-558-05245-2 Virtual ChemLab: General Chemistry, Student Lab Manual/Workbook, V. 2.5, Third Edition, by Brian F. Woodfield and

The goal of this was to successfully accomplish the synthesis of para-Chlorophenoxyacetic acid. In this experiment, para-Chlorophenoxyacetic acid was synthesized from 4-chlorophenolate and chloroacetic acid using an SN2 reaction. The product obtained was determined to be the para isomer of Chlorophenoxyacetic acid. This was confirmed by the melting point of 157.3-157.9 ◦C. The percent yield determined at the end of the experiment was 37.83 %. The TLC analysis showed that P-Chlorophenol was less polar than P-Chlorophenoxyacetic Acid because it had an Rf value of 0.38 in comparison to the value of 0.33 on a 50:50 hexane and ethyl acetate solvent mixture. In the NMR comparison, it was shown that both the starting material of chloroacetic acid and product contained a peak of integration two around 4 ppm representing the acidic proton. In the FT-IR comparison, it was determined that the Chloroacetic acid and the para-Chlorophenoxyacetic acid both had an OH bond at 3416 cm-1 and 3429.72 cm-1 respectively. The Chloroacetic acid and para-Chlorophenoxyacetic acid also both had a carbon-oxygen double bond at 1648 cm-1 and 1654.81 cm-1 respectively. The para-Chlorophenoxyacetic acid also contained a peak at 1236.18 cm-1 which represents the C-O-C bond.

Introduction: The purpose of this lab was to learn the proper techniques of roasting, smelting, and volumetric analysis to determine an unknown sample of copper mineral.

In this experiment, the experimenter will determine the chemical formula for the copper chloride hydrates using the law of definite proportions. The hydrated compound has a general formula of CuxCly•zH2O, with the variables x, y, and z. The variables represent the whole number ratio of moles that will be the “true” chemical formula of the hydrate. The chemical formula shows the number of atoms of each element in a compound.

Dictionary of organic compounds, 6th edition, Chapman and Hall, London, Volume 3(& Volume 6), 1996 Maria Lindsay and Sean P. Hickey, Organic chemistry lab 2 manual, department of Chemistry University of New Orleans

Infrared spectral analysis is consistent with the proposed structure and with other reported analyses [11-24]. The spectra all show bands characteristic of both reactants and new bands for the product assigned to the

The chemistry of heterocyclic compounds is one of the most complex and intriguing branches of organic chemistry, of equal interest in its theoretical implications, for the diversity of its synthetic procedures, and for the physiological and industrial significance of heterocycles. One of the most important heterocyclic scaffolds is quinoxaline. Quinoxaline is a bicyclic heterocycle consisting of a benzene ring fused to a pyrazine, hence a quinoxaline is also called Benzo[a]pyrazine, Benzopyrazine, Benzoparadiazine,1,4-Benzodiazine, Phenopiazine, Phenpiazine, Quinazine, and Chinoxalin. It is isomeric with quinazoline, phthalazine, and cinnoline (Figure 1).

Quinolines are remarkable scaffold found in several biological and pharmaceutical agents.1 Many tetrahydroquinoline moieties are known to be an interesting therapeutic agents.2 For example, the tetrahydroquinoline-based natural product (Fig.1) isolated from Galipea officinalis have been reported as potent antimalarial

Sriram et al. (2011) synthesized 2-(substituted aryl)-N-(substituted) thiazolidine-4-carboxamides. These compounds were synthesized from 2-(substituted aryl)- N-(substituted) thiazolidine-4-carboxamides . 2- (Substituted aryl)-N-(substituted) thiazolidine-4-carboxylic acids synthesized when Potassium acetate was added to a solution of L-cysteine HCl in water. Appropriate aldehyde was added to this mixture. To this mixture, desired primary or secondary amine was added to get required

The five active compounds were submitted to the evaluation of their in vitro potency against P. falciparum, and the standard drug mefloquine was used as reference parameter, as shown in Table 2. Mefloquine exhibited an IC50 value of 0.04±0.01 μM. In comparison to mefloquine, vanillinyl moiety-bearing derivatives of N-acylhydrazone-1,2,4-oxadiazole SintMed2 (4-mehylsubstituted), SintMed5 (4-bromosubstituted) and SintMed6 (4-nitrosubstituted) displayed potent anti-P. falciparum activities. While compound SintMed5 was found to be almost as potent as mefloquine with IC50 of 0.07±0.12 μM, the other two analogues SintMed2 and SintMed6 were less potent, but still exhibited expressive activities: 0.12±0.16 μM and 0.20±0.16 μM, respectively. Replacement

8-hydroxyquinoline (8-HQ) is a bicyclic compound derived from quinoline (1-azanaphthalene) and consist of two rings system: carbocyclic ring and pyridine ring with hydroxyl group substituted at position-8. 8-HQ is one of the most popular and versatile organic compound is an organic crystalline material. 8-HQ has typical phenolic properties, e.g. it gives violet colour with ferric chloride, couple with diazonium cations, and participate in Reimer-Tiemann and Bucherer reactions; its acetate ester usually undergoes the Fries rearrangement with aluminium chloride to give acetyl derivative [1]. As a result of the proximity of the hydroxyl group to the heterocyclic nitrogen, 8-HQ forms insoluble chelate complexes with a great variety of metal ions, including Cu2+, Bi2+, Mn2+, Mg2+, Fe3+, Al3+, Zn2+and Ni3+ [3]. The hydrogen of the hydroxyl group in 8-HQ is displaced and the metal is linked to both the oxygen and nitrogen.

Hydrazones are compounds obtained by the condensation of hydrazides with aldehydes or ketones. Substituted hydrazones can be obtained by introducing substituted hydrazides and carbonyl compounds. If the substituent is an acyl group, then it is called acylhydrazone. The –C=O group provides the possibility for the electron delocalization within the hydrazone moiety. General formula for a substituted acylhydrazone is shown in Fig. 1.

For this work, all the chemicals were used an analytical grade, and as received without additional purification. All aqueous solutions were made by using high purity deionized water with a resistivity (ρ) 18 MΩcm-1. Silver Nitrate (AgNO3, 99.0%), Copper (II) Sulfate Pentahydrate (CuSO4.5H2O, 99.0%), Povidone (PVP- (C6H9NO)n, 99.0%), Sodium borohydride (NaBH4, 99.0%), and Absolute Ethanol (C2H5OH,

Discovery of zoledronic acid was a result of highly extensive structure-activity relationship (SAR) studies from its prior generation bisphosphonates. It contains an –OH group which acts as an anchor and an unsubstituted heterocyclic imidazole group which imparts the superior activity to the molecule.

However, some of these methods have notable difficulties such as harsh reaction conditions, long reaction times, difficult work-up, low yields of the products, and use of toxic and costly reagents, catalysts or media. Also, some of the starting mate-rials have to be prepared and purified first, hence these methods are time-consuming. The develop-ment of simple and efficient methods for the syn-thesis of 1,4-dihydropyridines are therefore desirable. 1,4-Dihydropyridines are an important class of heterocycles, since many 1,4-dihydropyridine-containing natural and synthetic products exhibit attractive pharmacological profiles, including anti-inflammatory,2 antitubercular,3 anticonvulsant,4 HIV protease inhibitory,5 analgesic,6 antithrombi-otic,7