Niosomes are the novel carrier systems which have the bilayer structure. Niosomes can deliver both hydrophilic and lipophilic drugs. But niosomes are unstable. There will be the aggregation, leakage, storage and stability problems. Proniosomes are the versatile preparations which are stable. These are the dried forms of niosomes. Zidovudine proniosomal gel was prepared of different formulation. The permeation studies were carried using rat abdominal skin. Higher percentage release was achieved using the Span 20 i.e., 97.55%±1.1. Effect of lecithin and effect of non-ionic surfactants was carried out. The higher percent entrapment efficiency was achieved to F1 formulation of about 74.70%. There was no effect of cholesterol concentration. As the lecithin concentration was increased the percent drug release also increase but only at a certain extend. At the certain limit surfactant concentration also increases the drug release. By using the proniosomes as carries the bioavailability of Zidovudine increases to 97%. The proniosomes after hydration was characterized using the light microscopy and scanning electron microscopy. Proniosomes are suitable delivery systems for many of the hydrophilic and lipophilic drugs.
Key words: Zidovudine, Proniosomes, Lecithin, Surfactant, Stability, Bioavailability.
Transdermal drug delivery systems are the advantageous over the conventional drug delivery systems. This bypasses the hepatic first pass effect. It is very convenient