Non Small Cell Lung Cancer

What are lung cancers? Lung cancers are the abnormal cells which grow in uncontrolled manner in one or both lungs. They do not function as normal lung cells and do not develop into healthy lung tissue. The abnormal cells can grow, form tumours and interfere with the normal functions of the lung (Lungcancer.org, 2015). Lung cancers can be divided into two major types, namely non-small cell lung cancers (NSCLC) and small cell lung cancers (SCLC). NSCLC can be further classified into three main subtypes, namely adenocarcinoma, squamous-cell carcinoma and large-cell carcinoma (Longo & Harrison, 2012). Lung cancers can be diagnosed by chest X-ray, computerised tomography (CT) scan, positron emission tomography-computerised tomography (PET-CT) scan, bronchoscopy and biopsy (Nhs.uk, 2015). Unfortunately, lung cancers are often diagnosed at the later stages. This is due to the unrecognisable symptoms and warning signs at the earlier stages. NSCLC are often diagnosed at stage IV which accounts for 30-40% of cases whereas 60% of SCLC is diagnosed at stage IV. Lung cancer usually originates from the cells lining the bronchi, bronchioles and alveoli. Carcinogens especially tobacco smoke will alter the gene expression of the normal human lung cells, resulting in cell mutation. The proto-oncogenes will be converted to mutated form, oncogenes. Mutation leads to the decreased expression of the tumour suppressor genes. This results in uncontrolled cell proliferation, cell

Nicotine may significantly impact tissues lining the airway, particularly since it is present in cigarette smoke which is inhaled (3). One form of advanced cancer that involves these tissues is non-small cell lung cancer (NSCLC) (1). There are three types of NSCLC: squamous cell carcinoma, adenocarcinoma, and large cell carcinoma, all of which involve DNA

Non-small cell is the most common form of lung cancer. In fact 9 out of 10 cases of lung cancer are non-small cell. The other main type of lung cancer is small cell lung cancer, and together, they are the leading cause of cancer deaths in the United States, surpassing women’s breast cancer in 1987. In 2015, 221,200 people are expected to be diagnosed with some form of lung cancer. After a patient is diagnosed, their life expectancy drastically drops, as patients die on average within one year of being diagnosed. Non-small cell lung cancer accounts for 85% of the fatality rate.

Lung cancer is a genetic and acquired disease. Lung cancer is genetic because cancer in general is caused by changes to the genes that control the way our cells function, especially how they grow and divide. All of these changes include mutations in the DNA that makes up our genes. Genetic changes that increase cancer risk can be inherited from our parents, if the changes are presents in germ cells. Which are the reproductive cells of the body, those are the eggs and the sperm. Lung cancer is also acquired because as the result of errors that occur as cells divide a person’s lifetime or exposure to certain chemicals. Some examples of these chemicals are found in tobacco smoke, radiation, UV rays from the sun that damage DNA. “In general, cancer cells have more genetic changes than normal cells. But each person’s cancer has a unique combination of genetic alterations.” Some of these changes may be the result of cancer, rather than the cause. As the cancer continues to grow, additional changes will occur. Even within the same tumor, cancer cells may have different genetic changes.

Lung cancer can be caused by multiple factors and many factors can work together to cause someone to have lung cancer. Besides smoking, radon, secondhand smoke, the environment and someone’s occupation can all cause lung cancer. As we already know smoking is the number one cause of lung cancer cases worldwide and over forty-three million people just in the United States smoke cigarettes. There are more than fifty chemicals in tobacco smoke that are ingested each time someone smokes. Some of these chemicals include benzene (which can be found in pesticides and gasoline), Formaldehyde (which preserve dead bodies), pesticides (which are found on lawns and gardens) and Tobacco-specific N-nitrosamines (Martin, 2012). When a person inhales the chemicals in cigarettes, they inhale thousands of poisons, toxic metals, and

According to the US Department of Health and Services, More than 380,000 12-to-13-year-olds and almost four million 14-to-17-year-olds have smoked cigarettes at least once (Johnston, 2014, p.1). He also explained that the numbers of smokers between cigarettes, hookahs. E-cigarettes are increasing in the past few years between adults and teenagers (Johnston, 2014, p.3). I'm also concerned because my dad and my three brothers smoke more than 2 packs of cigarettes a day. Now let's discuss the causes of lung cancer.

With more than 1.61 million cases recognized annually lung carcinoma is that the leading cause behind cancer connected loss of life among men and second main cause in the back of loss of life in women worldwide [Jemal et al., 2011]. Morphologically the lung cancer is divided into small cell lung carcinoma (SCLC), non-small cell lung carcinoma (NSCLC) and adenocarcinoma (AC), with non-small cell carcinoma (NSCLC) accounting for 80% of all cases. [Brambilla et al., 2001]. The medical accomplishment in two decades has provided least effect on the treatment of the most cancers, the overall five year survival rate of NSCLC is roughly 15%.

Everyone knows cancer is the second leading killer in the United States. As people, we try our best to adapt when we hear a loved one has cancer. The question, “Why?” or “How?” always seems to come across our minds when hearing the diagnosis. Learning these common causes and risk factors may reduce a person’s chances in getting cancer. The most common mainstream product sold to cause cancer is cigarettes. ”Dangerous chemicals are found in tobacco use such as nicotine, Benzene, and Menthol (wood alcohol). Radioactive materials are in the tobacco leaves used to make cigarettes and cigars. Studies have shown the connection between tobacco products and lung cancer. Did you know? Lung cancer is one of the most preventable diseases that exist.

Smoking tobacco is one of the most common bad habits in the worldwide. A large amount of data has been collected on the issues of tobacco and overall health globally. The relationship between tobacco use and health initially comes from professional clinical observations about lung cancer, the first disease linked to tobacco use. Many people are not able to stop their addiction of smoking due to the fact that tobacco contains a common drug called nicotine that makes smokers feel as if they need to smoke all the time in order to function normally. Nicotine is a substance that is found in tobacco. It is also found in all tobacco products such as: cigarettes, chewing tobacco, and cigars. Cigarette smoking is regarded as a major health risk factor in the development of lung cancer, which it has been proven that is the main cause of cancer deaths in men and women in the United States and the world.

Tobacco consumption is one of the modifiable risk factors that causes or worsens numerous diseases and conditions. Tobacco used is the leading cause for cancer and cancer death in the world. Smoking increases the incidence of cancer of the lung, esophagus, kidney, bladder, stomach, colon etc. but also that of chronic diseases in particular cardiovascular disease, pulmonary disease like pneumonia, chronic obstructive pulmonary disease( COPD) while weakening the body’s immune system. Furthermore, smoking is responsible for the death of 480,000 people every year in the United States of America from which many are secondhand smoking.(Center for Disease Control and Prevention [CDC], 2016) Among other effects,

Cancer is the disease caused by an uncontrolled division of cells in a part of the body. Specifically, lung cancer is the uncontrolled growth of abnormal cells in one or both lungs. Since these cells are abnormal, they do not carry out the functions of normal lung cells and do not develop into healthy lung tissue. As they grow, these abnormal cells could possibly form tumors and interfere with the functioning of the lung, which provides oxygen to the body via the blood. In both men and women, lung cancer is the second most common cancer and is the leading cause of cancer death.

Nicotine is the primary component of tobacco products, which causes addiction and can eventually lead to lung cancer through series of metabolic activities. (http://www.carcinogenesis.com/article.asp?issn=1477-3163;year=2013;volume=12;issue=1;spage=1;epage=1;aulast=Warren ) Nicotine, which results from cigarette smoking, is found to be the major cause of lung cancer. Non-small cell lung cancer (NSCLC) is referred to as a type of lung cancer that is associated with epithelial cells (http://www.cancer.gov/cancertopics/pdq/treatment/non-small-cell-lung/healthprofessional/page1 ). The lung is covered by layers of epithelial cells connected with junctions that provide the function of transporting and secreting

Lung Cancer is partly preventable with smoking cessation and it is slowly decreasing in the developed countries because of the many campaigns against tobacco addiction developed in the last decades but this is not the case in developing countries. In addition, we are observing a growing amount of lung cancer in females. (Ferlay et al. 2008), (Le Chevalier).

It was one thought that lung cancer was strictly caused by lifestyle choices, but over the past years, it has been shown that lifestyle isn’t the thing that can potentially allow one to contract lung cancer. The environment along with tobacco use and genetics can also play a role in contracting lung cancer. In an industrial world, pollution has been a reoccurring problem. With emissions from vehicles and industrial power plants, air pollution and/or smog has been hovering over us. In places like China who are thriving in the industrial world, are being greatly affected by air pollution. According to Brody, “In Asia, lung cancer is alarmingly

The presence of these components in the sputum may cause mutations in the smokers genes, which may lead to the formation to cancerous tumors. The risk of developing lung cancer is directly related to the number of cigarettes smoked (Schaadt, 1992).