Non Small Cell Lung Cancer Research Paper

What are lung cancers? Lung cancers are the abnormal cells which grow in uncontrolled manner in one or both lungs. They do not function as normal lung cells and do not develop into healthy lung tissue. The abnormal cells can grow, form tumours and interfere with the normal functions of the lung (Lungcancer.org, 2015). Lung cancers can be divided into two major types, namely non-small cell lung cancers (NSCLC) and small cell lung cancers (SCLC). NSCLC can be further classified into three main subtypes, namely adenocarcinoma, squamous-cell carcinoma and large-cell carcinoma (Longo & Harrison, 2012). Lung cancers can be diagnosed by chest X-ray, computerised tomography (CT) scan, positron emission tomography-computerised tomography (PET-CT) scan, bronchoscopy and biopsy (Nhs.uk, 2015). Unfortunately, lung cancers are often diagnosed at the later stages. This is due to the unrecognisable symptoms and warning signs at the earlier stages. NSCLC are often diagnosed at stage IV which accounts for 30-40% of cases whereas 60% of SCLC is diagnosed at stage IV. Lung cancer usually originates from the cells lining the bronchi, bronchioles and alveoli. Carcinogens especially tobacco smoke will alter the gene expression of the normal human lung cells, resulting in cell mutation. The proto-oncogenes will be converted to mutated form, oncogenes. Mutation leads to the decreased expression of the tumour suppressor genes. This results in uncontrolled cell proliferation, cell

Cancer, it can affect anyone; it can affect any part of the body but what is it? Cancer results from the abnormality in the body's cells. This occurs when the cells divided and grow. Disruption in the system of the growth and division of a cell results in an uncontrolled division and proliferation of cells that form a mass which leads to cancer. The patient outcome for cancer is different for everyone, but it is also different with each type. In the respiratory department, a major type of cancer we will deal with is lung cancer. Lung cancer, however, has different types and stages, but for this paper, we are going to talk about Stage IIIA non-small cell lung cancer (NSCLC). In the article titled “Stage IIIA Non-Small Cell Lung Cancer” it states

Beneath the lungs, a slender, arch formed muscle called the stomach isolates the mid-section from the guts. When you inhale, the stomach climbs and down, compelling air all through the lungs. Lung tumor begins when cells of the lung get to be anomalous and start to become crazy. As more disease cells create, they can frame into a tumor and spread to different regions of the body. Non-little cell lung growth is a gathering of lung tumors that act likewise, for example, squamous cell carcinoma and adenocarcinoma. Side effects are a hack that won't leave, shortness of breath, weight reduction, or hacking up blood. Medicines incorporate surgery, chemotherapy, and radiation. Lung disease begins when cells of the lung get to be strange and start to become crazy. As more malignancy cells create, they can frame into a tumor and spread to different ranges of the body. Around 80% to 85% of lung growths are non-little cell lung malignancy (NSCLC). There are subtypes of NSCLC, which begin from various sorts of lung cells. Be that as it may, they are assembled together as NSCLC on the grounds that the way to deal with treatment and guess are regularly

Lung cancer is one of the leading causes of death not only in the United States of America but globally.1 According to the World Health Organization 8.2 million deaths in 2012 were cancer related and of those deaths, 1.59 million were due specifically to lung cancer.2 In 2014, there was a staggering 224,210 new reported cases of lung cancer in the United States alone. The 5-year relative survival has a 49% to 2% variability depending on the type of lung cancer, stage, and location. The two major types of lung cancer are Non-small cell lung cancer (NSCL), which consists of 85% lung cancers, and small cell lung cancer (SCLC), which makes up the other 15% of lung cancers. NSCL is an epithelial lung cancer that is histologically comprised of adenocarcinoma, large cell carcinoma, and squamous cell carcinoma.1 Both NSCL and SCLC are insidious in nature and the presentation will usually be vague or nonspecific and include the following symptoms: cough, shortness of breath, fatigue, weight loss, recurrent infections, coughing up blood, hoarseness, and wheezing.

The theme of this journal article was to explain to the audience the various sub types of non-small cell lung cancer, its risk factors, and the different procedures a patient has to undergo in order for them to be diagnosed with cancer. It does a great job answering a vast amount of questions the audience can have regarding the disease itself, the procedures used for prognosis and diagnosis of non-small cell lung cancer, and/ or the treatment available for patients with this disease. Overall, this report was very well detailed and provided the audience with a lot of

There are two types of lung cancer one being small cell lung cancer which occurs in heavy smokers. The other is non-small cell lung cancer thus including squamous cell carcinoma, adenocarcinoma and large cell carcinoma.

It is wise, however, to have a doctor monitor the tumor over at least a two-years period in order to note any changes that might indicate the presence of cancer. Also, a biopsy or surgical removal of a tumor may be needed when the patient is a smoker, the patient has difficulty breathing, or other troubling symptoms, tests show that the cancer could be present, and the nodule continue to grow. The malignant lung cancer is divided into non- small cell lung cancer, small cell lung cancer, and lung carcinoid tumor. First, the non- small lung cancer is A group of lung cancers that are named for the kinds of cells found in the cancer and how the cells look under a microscope. The cancer cells of each type grow and spread in different ways. The three main types of non-small cell lung cancer are squamous cell carcinoma, large cell carcinoma, and adenocarcinoma. Non-small cell lung cancer is the most common kind of lung cancer. The first type of the non- small cell cancer is squamous cell carcinoma About 25% to 30% of all lung cancers are squamous cell carcinomas. These cancers start in early versions of squamous cells, which are flat cells that line the inside of the airways in the lungs. They are often linked to a history of smoking and tend to be found in the central part of the lungs, near a main airway (bronchus). The second type is larger cell carcinoma this type accounts for about 10% to 15% of lung cancers. It can appear in any part of the lung. It tends to grow and spread quickly, which can make it harder to treat. A subtype of large cell carcinoma, known as large cell, neuroendocrine carcinoma, is a fast-growing cancer that is very similar to small cell lung cancer. The third type of non- small cell lung cancer is adenocarcinoma about 40% of lung cancers are adenocarcinomas. that begins in the cells that line the alveoli and make substances such as

Affecting more than 85% of lung cancer patients, there are more subtypes of non-small cell lung cancer. In non-small cell lung cancer (NSCLC), smoking causes about 90% of the lung cancers diagnosed. The risk mainly depends on how often and how much you smoked. Breathing in secondhand smoke raises the risk for developing lung cancer. Research shows that smoking marijuana may help the cancer cells grow even more. However, there is no direct link between smoking marijuana and developing lung cancer. Being constantly exposed to high levels of air pollution and drinking water that contains a high level of arsenic can increase your risk for lung cancer. Also, a history of radiation therapy to the lungs increases your risk for lung cancer (NLM). Early lung cancer may not show any symptoms, but some are: chest pain, cough that does not go away, coughing up blood, fatigue, shortness of breath, and wheezing. In later stages of NSCLC is: bone pain or tenderness (NLM). 39% of NSCLC occur in the small intestine. Obviously, non-small cell cancer mainly occurs in the digestive system and intestinal tracts of humans

I decided to choose small cell lung cancer because I have 1st hand knowledge about small cell lung cancer and the effects it has on human lives. Many people who are diagnosed with small cell lung cancer are often diagnosed in the late stages. Small cell often spreads very quickly and is very aggressive .Many people believe that everyone who has lung cancer received lung cancer from smoking, which is often not true. Smoking does increase a person’s chance of lung cancer, but no everyone that has lung cancer got it from smoking. After researching the topic for a various amount of time, I learned that women who are nonsmokers are often diagnosed with lung cancer. Small cell lung cancer often starts in the bronchi near the center of the chest. Small cell lung cancer

Lung cancer is the leading cause of death by cancer for both men and women in the United States (Stöppler, n.d., p. 3). As the name suggests, lung cancer is a cancer of the lung, where an abnormal growth of cells form a mass (tumor) on the lung (Stöppler, n.d., p. 2). This happens when a cell with aberrant DNA divides to create two new cells with the malformed DNA. This process occurs for each and every cell and because healthy lung tissue is not being made, a tumor develops. This tumor can be harmless, but in most cases, it is malignant and can have the potential to metastasize (“Lung Cancer 101,” n.d., p. 1). Lung cancer was not always the superior malady; in fact, only 1% of all cancers seen by the Institute of Pathology of the University of Dresden in 1878 were malignant lung cancers (Witschi, 2001). It appears

The symptoms of non-small-cell lung cancer is hard to be noticed in the early stages,

In this text I will be talking about SCLC(small cell lung cancer) and not NSCLC (non small cell lung cancer), the two main lung cancers. (according to www.lung.org) SCLC makes up 20% of all lung cancer cases and most associated with smoking. NSCLC makes up the other 80% of lung cancer cases but does not spread as fast as SCLC. NSCLC Comprises of: Adenocarcinoma, Squamous cell carcinoma,Large cell carcinoma.

Lung cancer is the leading cause of cancer-related mortalities in the world. An astounding average of 1.6 million deaths occur due to lung cancer yearly (1). Lung cancer is classified into two types: small cell and non-small cell lung carcinoma (NSCLC), where 85% of lung cancer cases are NSCLC. NSCLC has several different histologic subtypes, some of which are: squamous cell carcinoma, large cell carcinoma, and adenocarcinoma. Of the three, adenocarcinoma accounts for more than 50% of NSCLCs, making it the most common subtype (2).

FDG- PET/CT is a forefront in lung cancer screening, staging and treatment monitoring; its utilization may positively impact and improve the lives of patients diagnosed with lung cancer. This paper will investigate the efficacy of FDG- PET/CT in comparison to other screening tests, in the non-invasive evaluation of lung

|Specific Purpose: |To inform readers on the causes, effects and treatments of lung cancer. |