Nonalcoholic Fatty Liver Disease

1686 WordsFeb 25, 20187 Pages
Nonalcoholic fatty liver disease (NAFLD) is defined as accumulation of lipids, mainly triglycerides, due to causes other than viruses, alcohol, or genetics. The disease covers a wide spectrum of status, including simple steatosis, steatohepatitis, and cirrhosis, and is closely related to dyslipidemia, obesity, insulin resistance, and type 2 diabetes mellitus.1 Prevalence of NAFLD has been increasing gradually because of changes in lifestyles such as insufficient physical activities and westernized diet. NAFLD may be asymptomatic, but can be problematic as it is associated with other chronic diseases, including cardiovascular diseases and diabetes. Moreover, in some studies, it is shown to elevate mortality. Various tools are available for diagnosis of NAFLD, but some limitations do exist. For example, using hepatic ultrasound or computed tomography (CT) scan to screen asymptomatic patients is considered cost-ineffective, especially in mass screening. Laboratory tests necessarily involve an invasive procedure (i.e. drawing blood). Moreover, these tools cannot be accessed conveniently by non-practitioners, the fact being an obstacle for lay people to be involved in mass screening of NAFLD. The aforementioned reasons call for development of a new, easy-to-use model for screening NAFLD. In fact, however, there have been few simple, noninvasive and cost-effective systems that can predict NAFLD. Our group once developed a simple self-assessment scoring model for screening
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