Obesity And The Gut Microbiota

1694 Words Nov 20th, 2015 7 Pages
The gut microbiome supplies the human host with metabolic capabilities beyond those encoded by its own genome (Khan et al., 2014). Because host metabolism is effectively regulated by the amalgamation of host and microbial genes (Khan et al., 2014), we should expect the gut microbiota to play a fundamental role in the health of its host. A compendium of research evidence demonstrates a compelling link between obesity and gut microbial composition. The connection between obesity and the gut microbiota is illustrated in the effects of diet on microbial diversity, the association of host genotype with microbial plasticity, the correlation of microbial diversity and metabolic disease, and the modulation of host metabolism by gut microbiota.GWAS analysis identified 11 genome-wide significant loci associated with obesity traits, several of which overlap with loci identified in human studies. We also show strong relationships between genotype and gut microbiota plasticity during HF/HS feeding and identify gut microbial phylotypes associated with obesity.

The human gut microbiota is phylogenetically diverse, and the level of assortment can be assessed and influenced by one’s body composition, weight and diet. Ravussin et al. use four different classes of mice to test their hypothesis about the impact of diet composition and body weight on the variety of microbiota. First, the mice were divided into two groups: diet-induced obese (DIO) and control (CON) and subgroups of weight…
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