Olanzapine

risperidone whereas in this one there was a fixed dose to limit breach in blinding and to facilitate comparison between similar groups, also having this fixed dosage helped prevent bias because when using a titrating schedule of dosing in a randomized trial, it tends to show bias toward a desired goal. Risperidone in this study was well tolerated and there weren’t significant differences in weight gain or sedation(13). One of the main things disliked about risperidone is its tendency to increase the incidence of dyskinesia and other extrapyramidal side effects. In this study only mild and transient dyskinesias were seen in only 3 children, however that could be due to the low fixed dosage(13) of the study.

Antipsychotic medications may be prescribed as a means to control aggressive behavior that is brought on by dementia: Nearly 30 percent of Canadian seniors residing in long-term care facilities take antipsychotic medications despite the fact that they do not have psychosis. A report from the CFHI suggests that discontinuing these medications for an alternative treatment may be more beneficial to these seniors.

Antipsychotics are medications that physicians use to treat psychotic disorders such as Schizophrenia, Delusional disorder, Paraphrenia, and Substance-induced psychotic disorders. These disorders are characterised by the patient’s inability to make good judgments, think with a clear head, communicate effectively, relate to society, and understand reality. Antipsychotic drugs are also useful in the treatment of bipolar conditions that involve extreme cases of manic behaviour. Examples of these drugs include Thorazine and Trilafon. These drugs belong to a drug class called phenothiazines. They work by changing the actions of chemicals in the brain. The drugs can be beneficial, however, Steen et al. (2014) argue that the medicines have several harmful effects such as changes

In 1955, antipsychotic medications were introduced to help mental disorders. These medications are usually taken orally in which help relieve symptoms for periods of days. The misuse or abuse of the medications are low. There are three generations of antipsychotic medications. The first generation is known for reducing hallucinations and delusions, but not affecting problems like disorientation or depression. An example would be chlorpromazine, brand name being Thorazine. Some negative side effects of taking the first generation drugs are Parkinson’s-like symptoms, tardive dyskinesia, and weight gain. Next, the second generation drugs minimized the outcome of the individual getting Parkinson’s-like symptoms. An example of this generation would be Clozaril. “A unique feature of Clozaril is the 1 to 2 percent chance of developing a potentially lethal blood disease called agranulocytosis” (Levinthal 282). This disease decreases white blood cells and affects the immune system. If early signs of this disease start to appear the patient will stop taking Clozaril and recover. Lastly, the third generation has shown to be the most effective on schizophrenia. Abilify is an example of this generation drug. It does not have a risk of Parkinson’s, tardive dyskinesia, or diabetes. Abilify blocks specific serotonin receptors in which prevents negative side effects from happening. These different

Antipsychotics are generally used to treat psychosis in mental disorders. These disorders include schizophrenia and bipolar disorder (Thyssen et al., 2010). Risperidone is known as an atypical second generation antipsychotic and used in the treatment of a multitude of disorders. This medication can often challenge behavioral problems that are associated with schizophrenia, autism spectrum disorder, bipolar disorder, or attention deficit hyperactivity disorder (Schatzberg & Nemeroff, 2013). It is important for the prescriber to be aware of the side effect and any possible adverse reactions that may occur. There can be many detrimental side effects that someone may not enjoy,

Diamond in chapters 4, 7 and 9, looks at antipsychotic medications, medications useful for anxiety disorders and sleep problems and medication for people with borderline personality disorder respectively. Antipsychotic medications are profiled as second generation or first generation. Among the identified second generation antipsychotic medications are clozapine, risperidone, olanzapine, quetiapine, ziprasidone, aripiprazole and paliperidone. Clozapine is considered tpo be the most effective antipsychotic drug and has been proven effective as a mood stabilizer in treating “bipolar disorders that have not responded to mood stabilizers” (p. 72). Clozapine has side effects including those of weight gain, metabolic syndrome and increased risk

Risperidone is benzisoxazole derivatives of antipsychotic properties due to its high antagonistic effect on serotonin-5HT2 and dopamine-D2 receptors that magnifies its action in treatment of positive and negative schizophrenia with less extrapyramidal side effects and relapse probability (Rainer, 2008). Chemically it is C23H27FN4O2 (Bladania et al., 2008) (Figure 1). It is a weak base that is practically water insoluble, the solubility is pH dependent, it is highly soluble at acidic pH with significant decrease as pH increases up to pH 6.8 with minimum solubility at pH 8 (Saibi et al., 2012). Its bioavailability is about 70% with high protein binding ability (88%). It is extremely metabolized in liver to the active metabolite 9-hydroxyrisperidone

Antipsychotic medication, block dopamine and serotonin transmission in the brain. Clozaril, resperdal, zyprera, and seroquel are four newer antipsychotic medications. The symptom is alleviated with older antipsychotic medication. These are divided into groups depending on their potency. If a drug has a low potency, more of it is needed to relieve the symptom. Medium potency is only affective if medium dose is taken. High potency drug can be taken with smaller amount to be effective. Note that the antipsychotic drug, only reduces the psychotic symptoms of schizophrenia and usually allow the patient to function more effectively and appropriately. Most patients don’t need the drug. Even though the drug can’t elminate the disease. It can help the patient determine the difference between psychotic episodes from the real world. With continued drug treatment, about forty percent of recovered patient will suffer relapses within two years.

High dosages of benzodiazepines creates a massive clinical concern as patients can be easily dependent. Benzodiazepines are an incredibly abused drug in the U.S. Withdrawal treatment is recommended; however, it is sometimes unsuccessful for a large portion of patients. While ceasing the administration the drug all at once can be incredibly difficult for the patient and often times detrimental to the patient’s health, tapering is recommended by most doctors for allowing patients to successfully be independent from the drug and therapy during the tapering process is widely recommended and incredibly successful.

Möller (1999) has critically examined and analyzed the effectiveness, risk, and safety measures of using benzodiazepine that is consistent with Batelaan, Van Balkom & Stein (2012) idea. Moller (1999) argues that as much as benzodiazepine has many survival values, the drug is crammed with notable side effects and risks that can jeopardize the health of the patient. The author presented traceable basic pharmacotherapy of benzodiazepines that has played an imperative role in accounting the side effects of it. In addition, the author has provided pharmacological properties of benzodiazepines and linked the properties with side effects and potential risks. The author has analyzed the clinical indications and

Antipsychotic drugs are classified as either typical or atypical, based on their relative potency and side-effects. This classification is usually substituted with referring to typical as first generation and atypical as second generation, due to atypicals comparatively safer side-effects. However, it has been argued that due to the severe side-effects of both, the amount individual variation between psychotic patients, the patient’s tolerance to individual drugs, and the fact that antipsychotics treat symptoms rather than the psychosis, it might be better to class the drugs in regards to their mechanisms rather than their relative potencies [6][7]. Typical antipsychotics antagonise the D2 receptors and atypical antipsychotics target the D2 receptors among others (e.g. D3 and 5HT2 receptors).

They’re used to rebalance dopamine and serotonin to improve thinking, mood, and behavior, which can help you think clearly and take part in everyday activities. Aripiprazole can decrease hallucinations and improve concentration. It can also help with nervousness, severe mood swings and decrease how often they occur. Risperdal will help with hallucinations, delusions, disorganized thinking and speech, and social isolation. Both medications may cause sensitivity to extreme temperatures which can lead to dehydration. It may impair your thinking or reactions, lower blood pressure, dizziness and increase heart rate. Fatigue, sleepiness, headache, constipation, sexual dysfunction, and appetite increases are also common. Aripiprazole and Risperdal may increase the blood levels of a hormone called prolactin. Side effects of these increased levels include females losing their period, production of breast milk and males losing their sex drive or erectile complications. Long term elevated prolactin can lead to osteoporosis or increased risk of bone fractures. Some people may develop muscle-related side effects such as restlessness, tremors, and stiffness. Antipsychotics increase the risk of weight gain, high blood sugar, and high cholesterol. These serious side effects can lead to depression, lethargy, and

Antipsychotics: Olanzapine (Zyprexa), Risperidone (Risperdal), Quetiapine (Seroquel), Ariprazoe (Abilify), Ziprasidone (Geodon), Lurasidone (Latuda), Asenapine (Saphris)

Traditional antipsychotics are good at reducing the positive symptoms, but do not reduce the negative symptoms and are classified in low-potency and high-potency which can cause many side effects like; dry mouth, tremors, weight gain, muscle tremors, stiffness, motor disturbances, parkinsonian effects, akathisia, dystonia, akinesia, tardive dyskinesia, and neuroleptic malignant syndrome.

The efficacy and safety of the drug in patients under the age of 18 years is not established. With renal / hepatic insufficiency and long-term treatment, control over the picture of peripheral blood and liver enzymes is necessary. Patients who did not take previously psychoactive drugs respond to the drug at lower doses compared to patients taking antidepressants, anxiolytics or alcohol. With endogenous depression, alprazolam can be used in combination with antidepressants. With the use of alprazolam, patients with depression have seen cases of hypomanic and manic development. Like other benzodiazepines, alprazolam has the ability to induce drug dependence in long-term admission in large doses (more than 4 mg / day). With a sudden discontinuation of alprazolam, there may be comeback syndromes, such as depression, irritability, insomnia, increased sweating, especially with prolonged admission (more than 8-12 weeks). When patients develop such unusual reactions as increased aggressiveness, acute excitations, feelings of fear, thoughts of suicide, hallucinations, increased muscle cramps, difficult sleep, superficial sleep, treatment should be discontinued. During pregnancy Xanax is very dangerous due to its toxic effect on the fetus and increases the risk of congenital malformations when applied in the first trimester of pregnancy. Admission of therapeutic doses in later periods