Oncocytic Metaplasia Essay

Considering the possibility of malignancy in the lesion, the patient underwent a punch biopsy and a fine needle aspiration biopsy within one month of being seen by the ENT surgeon. Microscopically, the specimen consisted of normal appearing squamous epithelium overlying inflammed minor salivary glands which completely replaced by an infiltrate of lymphocytes and plasma cells. No malignant cells were seen in the fine needle aspirate.

Nasopharyngeal carcinoma which is also known as nasopharyngeal cancer or cancer of the nasopharynx. It is a cancer that begins in the upper part of the throat behind the nose and near the base of the skull. The nasopharynx is the upper part of the throat, the pharynx, which lies

Discussion activity - Discuss the difference between malignant and benign, and how cancerous cells differ from benign cells. Discuss how this might have an impact on the diagnosis coding. One thing that we never want to hear a doctor say to us is that we have a tumor. Tumors are classified

In our case Immunohistochemistry played a vital role to reach final diagnosis. These tumors were triple-negative ER,PR and Her2/neu. [12]. Immunonegativity for cytokeratin, EMA & CK 8/18 confirmed the

Pituicytomas are rare, non-adenomatous tumors arising from the neurohypophysis that are classically comprised of banal spindle cells arranged in short fascicles or in a storiform pattern. More recently, pituicytomas have been found to express thyroid transcription factor-1 (TTF-1), a unifying feature of uncommon tumors arising from the posterior lobe of the pituitary gland that also include spindle cell oncocytoma and granular cell tumor of the sellar region. We describe a unique example of a twice recurrent pituicytoma received in consultation which exhibited an array of uncommon histomorphologic features. A recurrent heterogeneously enhancing 3 x 2 x 2 cm sellar tumor was transsphenoidally resected from a 68-year old male, status post two

Monse Padilla Mr. White Anatomy/Physiology 3A 25 January 2016 Brown Tumor There are lots of tumors out there in the world, but the one that we are going to focus on is a Brown Tumor. A tumor is an abnormal tissue that is

post-injection. The sentinel lymph nodes (SLNs) were then marked on the skin using a radioactive tracer to locate the level of the sentinel nodes found on lymphoscintigraphy. Once in the operating theatre and after induction of general anaesthesia, 1-2 mL of methylene blue dye was injected in the normal mucosa and submucosa surrounding the pri-mary tumour. U shaped skin incision, elevation of subplatysmal plane with 3 selective lateral neck dissections level II, III and IV. The SLNs and echelon lymph nodes (ELN) were identified using combinations of gamma probe localisation and identification of blue-stained lymphatics and lymph nodes. These nodes were then resected; their radioactivity measured ex vivo and labelled according to their colour, radioactivity and anatomical neck level. These nodes were then sent individually for histological analysis in 10% formalin. The laryngeal tumour was removed either with partial or total laryngectomy according to the tumour stage and sent for histological examination. In some cases, the primary tumour was removed prior to exploring the neck. The number of radioactive-only nodes, the number of blue-only nodes, the

ImageA higher power view showing that the cells do not display any structural abnormality and the tumour is seen to have well shaped glands which possess several nuclei, further proving that the tumour is still in its benign stage.

On histopathology, the tumor is characterized by numerous giant cells, which vary in size from 10 µ to 100 µ and exhibit many centrally placed uniform nuclei. The other components of the tumor are the spindle cells. These are oval, elongated and contain large nuclei with a small amount of acidophilic cytoplasm. It is believed that the spindle cells are the malignant component of the tumor rather than the giant cells. Therefore, the tumor aggressiveness depends on the spindle cells and not the giant cells [ref].

A 20-year-old female presents to her primary care physician’s office complaining of a lump on the left side of her neck. She first noticed the lump when taking a shower 6 months ago and has been “keeping an eye on it” ever since. The patient states that it is gradually increasing in size and is painless. She has no other medical problems to her knowledge and has been healthy her whole life. Her vital signs are within normal limits, and physical examination shows a solid, nontender mass on the left side of her neck. The mass measures about an inch in diameter. A biopsy is performed and shows the following:

C-ALCL is common type of cutaneous T-cell lymphoma accounting for In the majority of cases the tumour cells have round, oval, or irregularly shaped nuclei, prominent eosinophilic nucleoli and abundant cytoplasm1, thus exhibiting characteristic morphology of anaplastic cells. Less commonly, they have a non-anaplastic appearance thus are pleomorphic or immunoblastic in approximately 20-25% 25, 27. On the periphery of the lesions, reactive lymphocytes are present. Also ulcerating lesions may have a LyP-like histology with a vast inflammatory infiltrate of reactive T-cells, histiocytes, eosinophils, neutrophils and relatively few CD30-positive cells. Thus, in these cases hyperplasia may be seen. In the rare neutrophil-rich pyogenic variant the inflammatory background is very abundant 4,

Oral squamous cell carcinomas are rapid in growth and are not due to sunlight exposure. Refusal to eat due to the tumors on the tongue and/or surrounding gums, drooling, bad breath, and swollen lymph nodes, are symptoms. Oral carcinoma’s needs to be diagnosed early. If not, the prognoses is not good and death is eminent.

Oral malignant melanoma of the mouth is an extremely rare tumor arising from the uncontrolled growth of melanocytes found in basal layer of oral mucous membrane. Melanocytes are neural crest derived cells that migrate to the skin, mucous membrane and several other sites. It was first described by weber in 1859. Its incidence is estimated to vary widely between 0.2% and 8% of all melanomas and 1.3% of all cancers. Approximately 80% of oral melanomas arise in mucosa of upper jaws in elderly patients with majority occurring on keratinizing mucosa of the palate and alveolar gingivae. Other sites include buccal mucosa, mandibular gingivae, tongue and floor of the

RESULTS: A total of 1855 biopsy specimens were accessioned at our biopsy services during the study period (2002 – 2006). In this period, 37 cases were salivary gland neoplasms accounting to 1.99% of all biopsy specimens accessioned. Of 37 cases, 11 were benign neoplasms (29.72%) and 26 were malignant (70.27%). The common tumors overall was Pleomorphic adenoma (PA) and Muco-epidermoid carcinoma (MEC) (Table 1).

• The literature review was detailed explaining the etiology diagnosis and treatment of the disease however limited literature references were mentioned to support the conclusion that, Oral cavity lesions can be the first sign of relapse or succession of myeloma.1