Opioids Research Paper

Opioid addiction is so prevalent in the healthcare system because of the countless number of hospital patients being treated for chronic pain. While opioid analgesics have beneficial painkilling properties, they also yield detrimental dependence and addiction. There is a legitimate need for the health care system to provide powerful medications because prolonged pain limits activities of daily living, work productivity, quality of life, etc. (Taylor, 2015). Patients need to receive appropriate pain treatment, however, opioids need to be prescribed after careful consideration of the benefits and risks.

"If we could sniff or swallow something that would, for five or six hours each day, abolish our solitude as individuals, atone us with our fellows in a glowing exaltation of affection and make life in all its aspects seem not only worth living, but divinely beautiful and significant, and if this heavenly, world-transfiguring drug were of such a kind that we could wake up next morning with a clear head and an undamaged constitution - then, it seems to me, all our problems (and not merely the one small problem of discovering a novel pleasure) would be wholly solved and earth would become paradise."

The opioid crisis was caused by a variety of factors, but the main reason why these drugs are in the spotlight is because of the actions of the drug manufacturers. In order to fully understand the spark of the opioid crisis, it is imperative to understand what makes these drugs so potent. Writer and crime journalist Sam Quinones states that opioids are synthetic drugs. Naturally sourced drugs, known as opiates, are derived from the opium poppy plant. However, experts use both of these terms interchangeably. The use of opioids grew around the late 90s, and legally, most people used these drugs for pain relief. However, the people that were using these drugs had little information as to how addicting opioids actually were. In fact, opioids are

As we see the further progression of the opioid epidemic within the United States, pharmacists become the frontlines to recognizing and providing care for these patients. It is however difficult to provide care for a patient when even the professionals within the medical community have an associated stigma attached to the use of these drugs. Patients who have a need for these painkillers recognize this stigma, and by doing so decide to avoid consulting their doctors and do not seek the care which they need. They do this to avoid the discriminatory treatment they receive both within and on the outside of the healthcare system, and to avoid the legal repercussions associated with the misuse and abuse of these products1. It is therefore the pharmacists' job to avoid the stigmatization of these people and respect those who use these treatments for legitimate medical purposes.

Vivek Murthy, a U.S. Surgeon General, said he wanted to change the way Doctors have been taught to handle pain management for the last twenty to thirty years (824). The reason Murthy wants to do this is because while he was reading a training document for nurses and doctors it claimed , "If your patient is concerned that they may develop dependence on opioids, you can safely reassure them that addiction to opioids is very rare in patients who have pain" (823). This document also reassured doctors they could prescribe opioids as a long-term treatment. The Center for Disease Control and Prevention advises doctors that pain-relieving effects may wear off for long-term users(824). This explains how opioids can be used to deal with pain management, but if used as a long-term treatment it can create an

According to NIH, millions of people suffer from opioid use disorder throughout the United States. This epidemic has continued to spread and the numbers of people who are becoming addicted is on the rise so much that the total burden of cost is at 78.5 billion dollars per year for prescription opioid misuse, this includes the cost of addiction treatment, criminal justice services, and health care (NIH, 2017. https://www.drugabuse.gov/drugs-abuse/opioids/opioid-crisis) Unfortunately there does not seem to be an end to this epidemic anytime soon. The numbers are unremarkable; natural and semi-synthetic opioids peeked at 14,427, heroin at 15,446 and synthetic opioids other than methadone at 20,145. That is a total of 50,018 deaths for some type

Opioid abuse, misuse and overdose is a problem in The United States. You can’t turn on the TV or read a newspaper without some mention of the epidemic. This issue has caused the practice of prescribing or taking narcotic pain medication to be looked at under a microscope. Patients are fearful to use some necessary pain medication, because they may become addicted. Other patients who genuinely do have pain and need medication are having a tougher time obtaining the help they need. The problem of abuse and addiction is tough to solve since for some people the medications are the only way they can function and live a semi-normal life. A patient with pain may be hesitant to visit the doctor and

The history of opioids in America provides a reoccurring theme riddled with misuse, abuse, and addiction. One could even go as far as to call it a timeless theme, as the same problems that affected the past still stand steadfast today. It all started in 1806 with the isolation of Morphine by chemist Friedrich Sertürner (Acock, 1993). Soon after its creation, this analgesic opiate became the primary treatment in the United States for various medical ailments including pain, anxiety, and respiratory problems (Acock, 1993). Acock (1993) reveals that opioids were widely used during the Civil War, with numbers reaching up to ten million opioid pills for the Union Army alone. Morphine was essentially the cure-all on the battlefield. The result

For thousands of years, opiates have been used in the treatment of pain. Opium is believed to have been discovered 6000 BC, and since then, it has had a huge impact on both medicine and the recreations of those seeking euphoria. More recent than the ancient discovery of natural opium are the derivatives of opium, such as the alkaloids morphine, codeine, and thebaine. From these alkaloids, semi-synthetic opiates can by synthesized, such as hydrocodone, and oxycodone. Synthetic opioids are also quite prevalent, which include fentanyl and tramadol. Opium can also be processed into heroin, a morphine derivative. As advancements were made in science and engineering to allow for a wider distribution and usage of opiates, the problems of dependence and overdose also increased drastically. According to Hart and Ksir (2013, p. 302), the invention of the hypodermic needle for intravenous administration of morphine and other drugs allowed for a much faster and more potent dose of the drug. With this increased potency came an increase in the possibility of a recreational intravenous user to overdose. Hart also mentions that some of the wars surrounding the era of the synthesis of morphine may have contributed to the rise of morphine, seeing as a medic soldier’s motto was always “first provide relief” (2013). This relief-driven attitude and extensive use of opioid analgesics in medicine during the time, in addition to the large amount of patent medicines and remedies on the market may

Oxycodone is the main drug I am concentrating on even though there are many opiates or schedule II drugs that are considered Opioids. Oxycodone was created during the process to find a drug that was not addictive like morphine and heroin, which were commonly used in medicine before World War I(? A Forever Recovery. 2014. Web. 10 Mar. 2016?). Oxycodone is an opioid analgesic, ?Pain Killer? that is most often prescribed to control moderate to severe pain that must not be used with other medications. It is a slightly synthetic opiate that was created in 1916. The chemicals found in Poppy plants also make as morphine and heroin. Opiate:?A drug (such as morphine, codeine or heroin) containing or made from opium or the opium poppy, used to alleviate pain, or induce sleep or euphoria. ( A Forever Recovery. 2014. Web. 10 Mar. 2016). Opioid:?A synthetic or semi-synthetic substance producing an opium-like effect, often prescribed for the alleviation of moderate to severe pain; a prescription painkiller in the opiate class.

Oxycodone is the main drug I am concentrating on even though there are many opiates or schedule II drugs that are considered Opioids. Oxycodone was created during the process to find a drug that was not addictive like morphine and heroin, which were commonly used in medicine before World War I(? A Forever Recovery. 2014. Web. 10 Mar. 2016?). Oxycodone is an opioid analgesic, ?Pain Killer? that is most often prescribed to control moderate to severe pain that must not be used with other medications. It is a slightly synthetic opiate that was created in 1916. The chemicals found in Poppy plants also make as morphine and heroin. Opiate:?A drug (such as morphine, codeine or heroin) containing or made from opium or the opium poppy, used to alleviate pain, or induce sleep or euphoria. ( A Forever Recovery. 2014. Web. 10 Mar. 2016). Opioid:?A synthetic or semi-synthetic substance producing an opium-like effect, often prescribed for the alleviation of moderate to severe pain; a prescription painkiller in the opiate class.

Chronic pain describes pain that persists over long periods of time. It handicaps the normal lifestyle and quality of one’s life (http://www.asri.edu/neuro/brochure/pain1.htm).

As mentioned briefly before, the placebo analgesia mechanism might work through the release of endogenous opioid analgesics, the body’s natural narcotics that are produced as a reaction to stress and pain. The reason for this belief is that studies have shown that naloxone, a narcotic antagonist, reduces the pain-killing effects of placebos. (2) (21) (22) Despite the fact that other studies have not found naloxone to have any effects on placebo responses, (23) (24) the opioid theory is the most widely accepted theory when it comes to the explanation of placebo pain-reduction. In opioid analgesia, the rostral anterior cingulate cortex (rACC) shows a high activity, as this brain region has many opioid receptors. If the placebo analgesia really

Chronic pain is defined as pain that lasts for six months or longer. Did you know that there are nearly 100 million people in our country who suffer from chronic, daily pain? These are the cases that are documented - many people suffer in silence.

Chronic pain is defined as a pain that doesn’t go away for a long time. The pain can last for weeks, more than 3 months, years, and might make someone feel hopeless. Chronic pain does not relief with regular pain medication. It is important to address chronic pain because is physically and psychologically stressful. Its persistent discomfort can lead to irritation and frustration with the person’s self and with other people. Pain affects not only mental health but interfere also with someone’s sleep pattern.