Oral And Recurrent Pregnancy Loss

1673 Words Nov 19th, 2014 7 Pages
Association between Angiotensin Converting Enzyme Insertion/Deletion (I/D) Polymorphism and Recurrent Pregnancy Loss
Aisha Mahmood Fageer, Elshazali Widaa Ali, Nasr Eldeen Ali Mohamed
Department of haematology, Faculty of medical laboratory sciences, Al Neelain University, Khartoum, Sudan

Corresponding author: Dr. Elshazali Widaa Ali Mohamed Ahmed, Ph.D
Faculty of medical laboratory sciences, Al Neelain University, Khartoum, Sudan
Mobile: 00249122694501, E-mail: elshazaliwidaa@gmail.com
Abstract
Background: Recurrent abortion or recurrent pregnant loss (RPL) is a common clinical problem, and for most women the cause is unknown. Angiotensin-converting enzyme (ACE) affects vascular structure and placental function, and its role in blood pressure regulation and electrolyte balance is well documented, as well as it is play a role in regulation of fibrinolysis indirectly.
Objective: This study aimed to examine the association of the ACE I/D polymorphism with recurrent pregnancy loss in Sudanese women.
Materials and methods: It is a case-control study, in which 40 patients with RPL and 40 healthy women with one or more successful pregnancies were enrolled. Salting out method was used for DNA isolation from peripheral blood leukocytes, and PCR was used to determine the ACE genotypes (DD, ID, and II).
Results: In women with RPL the frequencies of ACE genotypes were found to be 57.5% for DD, 35.0% for ID, and 7.5% for II. in the control group the frequencies were 92.5% for DD,…
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