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Oral Anonymous Cell Carcinoma Essay

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Oral Squamous Cell Carcinoma (OSCC) is the most common cancer of head and neck region.1 Each year it affects as many as 274,000 people around the world and 2-4% in western countries and 40% in Indian subcontinent.2 The incidence of oral cancer has both familial and genetic predisposition. It is commonly associated with the risk factors like chewing of tobacco, areca nut and betel quid. In developing countries this is often an indicative pattern causing high prevalence unlike developed countries where cigarette smoking and alcohol consumption is more common and prevalence is rather less.3, 4 Lack of early diagnosis is another key factor, may be either due to negligence of early lesion by patient or sample examination by health care workers.3 Early diagnosis has shown chances of 5-year survival rate as high as 80% of cases along with decrease in patient morbidity and suffering.3
Malignancy on 30% to 80% occasions arises from potentially malignant disorders like leukoplakia, erythroplakia and oral submucous fibrosis.4 Genetically it shows alterations characterized by
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In our study we intend to use the exfoliated cells from cases of oral leukoplakia and OSCC using MGP and Papanicolau (PAP) stain. Our aim is to determine an easy-to-use and cost effective method by staining the most important cellular components (DNA & RNA) using the special stain (MGP) in order to evaluate the probable changes occurring prior to morphological changes in premalignant and malignant lesions and to correlate such changes with clinically normal oral cytology and PAP staining method, determining the effectiveness of the stain and its diagnostic
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