Oral Anti Diabetic Agents Are Used As Pharmacotherapy Options

Diabetes can be treated in three basic ways: by diet, by diet in conjunction with tablets, or diet in conjunction with insulin. Diet serves as an initial control for non-urgent patients. If a person’s diet will have a major effect on glycaemic control, it does so reasonably quickly, within a few weeks of changing

Answer: The combination of Insulin as well as oral hyperglycaemic drugs may be prescribed for Diabetes because they help in lowering the blood glucose levels. However the primary treatment doesn’t consist of these drugs. The primary treatment comprises of Diet control, Physical activity and Weight control. If after following the primary treatment strictly, no improvement in the blood glucose level is achieved then medication is suggested for the same. Insulin helps in maintaining the blood sugar levels. Note that insulin is not to be taken orally because the acids and digestive juices in the stomach destroy it. It has to be injected under the skin only. Taking insulin leads patient to experience Hyperglycaemic condition. The Hyperglycaemic drugs helps our body to react appropriately with the insulin so that the insulin hormone is able to help transfer glucose from blood to the cells successfully.

“Diabetes pills are members of six classes of drugs that work in different ways to

Diabetes is a growing concern and health challenge for the American people (b). Diabetes is a condition in which the body cannot react to insulin appropriately or either cannot produce insulin efficiently (w). “Without a properly functioning insulin signaling system, blood glucose levels become elevated and other metabolic abnormalities occur, leading to the development of serious, disabling complications” (w). There are numerous forms of diabetes amongst the nation, however, there are three main forms of diabetes. Most people have heard of type one diabetes, type two diabetes, and gestational diabetes because they are common. Type two diabetes deals with a resistance to insulin, while

Treatment of diabetes is important to minimize the harm that is done to the body by diabetes. In addition to exercise and a special diet, type 1 diabetes patients need regular insulin injections to lower the blood sugar levels, while people with type 2 diabetes usually don’t need insulin shots, most of them require insulin tablets in addition to healthy diets and regular exercise and a few don’t even need the insulin tablets. (2, 7)

1 January 2017. The purpose of this source is for general scientific research and understanding diabetes. This gives the view on ongoing research, equipment modifications, changes in governmental regulations and the constant flow of information relating to the use of medicines, equipment and

Glyburide is another generic medication used in the management of diabetes mellitus type 2. Two trade names of this drug are DiaBeta and Glynase. The chemical name is 1-[ [p-[2-(5-chloro-o-anisamido) ethyl]phenyl]-sulfonyl]-3-cyclohexylurea. Doses up to 0.75-12 mg/day can be given as a single dose or divided doses. The circulation of the glyburide is that protein binding is extensive and half-life is 10 hours. It is excreted through the renal and biliary system. Glyburide acts as an oral blood glucose lowering drug. The drugs uses include binding and activating the sulfonylurea receptor 1, which causes depolarization. This results in an increase in intracellular calcium in the cells and stimulation of insulin release. Major drug interactions are noted between glyburide and

Diabetes is a metabolic disease where an individual’s blood glucose level is higher than normal standards. Diabetes is a long term condition that causes not only primary issues related to the disease but secondary problems as well. Diabetes also known and referred to by healthcare professionals as diabetes mellitus, which is a phrase used to describe a group of metabolic diseases in which a person’s body does not produce insulin at all, or a person’s body does not use insulin properly, which is called insulin resistance. Type I Diabetes also known as juvenile diabetes is when the body does not produce insulin, approximately 10% of all diabetes cases are type I. Type 2 diabetes is when the body does not use insulin properly and approximately 90% of all documented cases worldwide is of this type. (American Diabetes Association, 2014) All types of diabetes can be treated, type I has no known cure however there have been some cases where

Furthermore, with the pharma logical treatments included in this article for the treatment of Type 2 Diabetes, many individuals will be prevented from developing CVD complications. Studies have shown the importance of patients being compliant with treatment leading to positive health outcomes. With the continued care given to these patients with Type 2 Diabetes many are able to have healthier lifestyles

Prescription drugs are a major life factor to both young and old in our society. The vast variety of drugs used to treat many medical conditions is endless. Firstly, glyburide (Diabeta) is an oral diabetes medicine that helps control blood sugar levels. Diabeta is the trade name for glyburide; similarly glyburide is the generic name for Diabeta. Glyburide (Diabeta) is of the sulfonylurea class (hypoglycemic agents) which treats type two diabetes (Sorrentino, 2013). Because of glyburide medications, the pancreas releases more insulin into the blood stream. In type two diabetes, the body is unable to store excess sugar, and therefore, this sugar remains in the bloodstream (Web MD, 2013).

As the incidence of type 2 diabetes is steadily increasing, the demand for treatment options is increasing. Dipeptidyl peptidase-4 inhibitors (DPP-4) are a new class of oral anti-hyperglycemic medications that target the incretin system found in the gut. Evidence has shown that treatment with DPP-4 inhibitors has shown significant reductions in HbA1c and increased pancreatic β-cell function without an increased risk of hypoglycemia. In this document, the pharmacology, clinical efficacy, and incidence of adverse effects will be reviewed in an attempt to target a patient population that would benefit the most from treatment with DPP-4 inhibitors.

Metformin is widely used to treat type 2 diabetes who do not have severe nephritis, cardiovascular disease or liver disease. It is one of the best first line treatment for type 2 diabetes which was first marketed named as Glucophage. Metformin also used in the treatment of polycystic ovary syndrome and increasing the use day by day.

In a phase 2 trial, patients with type 2 diabetes with active comparator were treated with MSDC-0160. This study will further evaluate the safety and efficacy of MSDC-0160, and reveal its effectiveness in the treatment of type 2 diabetes. (Clinical trial information:

Lo C, Toyama T, Hirakawa Y, Jun M, Cass A, Hawley C, Pilemore H, Badev SV, Percovic V, Zoungas S. Insuline & Glucose lowering agents for treating people with diabetics and chronic Kidney disease. Cochrane Database of systematic reviews 2015, Issue 8. Art. No. CD011798. DOI:10.1002/14651858.CD011798.

Diabetes is a systemic disease caused by a decrease in the secretion of insulin or reduced sensitivity or responsiveness to insulin by target tissue. (Beale, et al., 2011) The incidence of diabetes is growing rapidly in the United States and worldwide. An estimated 347 million people around the world are afflicted with diabetes. (Whalen, et al., 2012) According to World Health Organization (WHO), Diabetes prevalence among adults over 18 years of age has risen from 4.7% in 1980 to 8.5% in 2014. It is the major cause of blindness, kidney failure, heart attack, stroke and limbic amputation. World Health Organization (WHO) projects that diabetes will be the 7th leading cause of death in 2030. It is a complex and costly disease that can affect nearly every organ in the body and result in devastating consequences. The leading cause of non-traumatic lower extremity amputations, renal failure, and blindness in working-age adults, diabetes is also a major cause of premature mortality, stroke, cardiovascular disease, peripheral vascular disease, congenital malformations, perinatal mortality, and disability. (Cefalu, 2000) Insulin therapy and oral hypoglycemic agents have demonstrated improvement in glycaemic control. However, Insulin therapy has some disadvantages such as ineffectiveness following oral administration, short shelf life, of the need for constant refrigeration, and fatal hypoglycaemia, in the event of excess dosage.