Organisms Maintain Protein Fidelity And The Body ( Labbadia Et Al

940 Words Oct 17th, 2016 4 Pages
Proteostasis is the way that organisms maintain protein fidelity in the body(Labbadia et al., 2015). It consists of multiple different mechanisms which help to coordinate protein synthesis, folding, disaggregation, and degradation(Labbadia et al., 2015). The multiple mechanisms that help to achieve proteostasis make up a system called the proteostasis network. This network incorporates all of the processes of proteostasis, including all machinery including translation, molecular chaperones, co-chaperones, the ubiquitin-proteome system, and the autophagy system(Labbadia et al., 2015). The unfolded protein response in the cytoplasm, endoplasmic reticulum, and mitochondria are not considered to be a direct part of the proteostasis network, however.
Chaperones are one of the ways that the body can help to regulate the folding of proteins. Chaperones can work alone or with cochaperones in order to assist with the folding, disaggregation, degradation, and trafficking within the cell(Labbadia et al., 2015). Because chaperones are so important for the cell’s existence, expression of chaperones is often increased with cellular stress. The unfolded protein response (UPR) in another process that cells undergo to make sure that proteins are folded correctly. This process can take place in the cytoplasm, the endoplasmic reticulum, and the mitochondria. If there is a buildup of unfolded proteins in the cell, the unfolded protein response kicks in and activates intracellular signal…
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