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Orientia Tsutsugamushi

Satisfactory Essays

Orientia Tsutsugamushi is a Gram negative bacterium, and this microorganism is an obligate intracellular pathogen. Orientia Tsutsugamushi can cause scrub typhus disease. The microorganisms rapidly abscond from the pathway inside of the body, and then copies in the cytosol of eukaryotic host cells after entry into host cells (Ko). Orientia Tsutsugamushi has developed to block autophagy microbicide defense by escape autophagy recognition. It activates the autophagy way at the early stage of infection. According to Mizushima, “autophagy is an evolutionarily conserved and regulated intracellular catabolic mechanism that mediates the degradation of cytosolic components, including protein complexes and damaged organelles, in a lysosome-dependent

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