Osteoarthritis Persuasive Essay

The recovery period after large scale injuries could be shortened. The effects are analyzed in an article that states, “True healing could occur thanks to the cloning of their own cells to help the recovery process” (“Pros and Cons” 5). Basically, the process of cloning healthy cells could be used as an aid in replenishing damage of unhealthy cells. This process, if it were to be actualized, could help recovery progress in anything from pulled muscles to the paralysis of an entire limb. In theory, the same research can be applied in other areas. If this technology is paired with stem cell research, it could result in a method of repairing physical damage. An article that focused on advances in biotechnology stated that “Another use of cloned stem cells could be the growth of replacement tissues in the laboratory” (LaPensee 15). Necrosis, apoptosis, and lymphocyte diapedesis all cause tissue damage or death. These tissues could be replaced by cloned cells of healthy tissues. This shortens recovery periods and leads to healthier tissue growth.

The NFL has taken a hit in recent months due to a multitude of players taking a knee during the National Anthem. People around the globe are in an uproar about the recent events. Actions are being taken everywhere, whether that be supporting the measures being taken or rebelling against them by no longer watching the National Football Leagues on Sunday nights. Nevertheless, actions are being taken, these just may not be the actions they wanted to see.

Osteoarthritis is the most common joint disorder, and more than half of all Americans who are older than 65 have been diagnosed with osteoarthritis. However, recent US data has revealed knee osteoarthritis does not discriminate age, and there is growing evidence that osteoarthritis affects individuals at a young age. The annual cost of osteoarthritis due to treatment and loss of productivity in the US is estimated to be more than 65 billion dollars.1 With no cure currently available for osteoarthritis, current treatments focus on management of symptoms. The primary goals of therapy include improved joint function, pain relief, and increased joint stability. Although the exact cause of osteoarthritis is unknown, many risk factors have been identified including increased age, female gender, obesity, and trauma.2 Within these risk factors, the etiology of osteoarthritis has been divided into anatomy, body mass, and gender.

Regenexx is offering non-surgical treatment for orthopedic indications such as arthritis, bursitis, ligament tears and much more. According to their website, The Regenexx is the longest running stem cell therapy company in the United States. Company’s co-founder Dr. Christopher Centeno is a founding member of the International Cellular Medicine Society and one of the most experienced physicians of clinical use of adult stem cells in the world.

In a 58 year-old male, suffering from facet joint syndrome and spinal canal stenosis, adipose derived stem cells were injected into the facet joint under fluoroscopic guidance.

In Identification and Specification of the Mouse Skeletal Stem Cell (Cell, 2015), the Longaker lab explores the differentiation of skeletal stem cells into bone, cartilage, and stromal tissue. Analyzing mRNA present in the cell at different stages of differentiation allowed for determination of the genes that govern which cell type a skeletal stem cell makes. This knowledge was used to shift cell fates from cartilage to bone and vice versa. Additionally, the introduction of BMP2 and VEGF inhibitor allowed for the creation of cartilage in fat tissue. These experiments demonstrate a robust knowledge of the genes that govern the distinct outcomes for differentiated skeletal stem cells. Finally, it was observed that the skeletal stem

Advances in medical technology are making it possible for people to get treatment for conditions that were previously either difficult to treat or that required highly invasive surgery. Now, minimally invasive methods of treatment are being developed so that patients who do not have severe or life-threatening health conditions may be able to find relief without the risks and rehabilitation that accompany surgery. One example of a technology that is revolutionizing the field of orthopedics is stem cell therapy, which is a form of regenerative medicine.

Bone Injuries are very frequent all over the world commonly in the United States. According to the American Academy of Orthopaedic Surgeons, approximately six million people break their bones yearly. Out of this six million, 300,000 of these injuries heal over a long period of time or don’t heal at all. Due to emerging technology scientist and researchers on this field of expertise are now able to study these injuries and find a solution to this. Stem cells seem to be a favorable and effective way to treat bone injuries. Bone injuries are common among athletes of all sports. Finding a “cure” to this problem would serve as a way to get players back into shape in the least amount of time possible. We now discovered that stem cells can be manipulated and stimulated in our advantage. This stimulation would encourage the production of a cartilage that could repair long bone injuries.

On January 8th, 2016, Athersys, a clinical stage biotechnology company, extracted stem cells from adult bone marrow donors. "The stem cells caused less injury of the tissue and enhanced the healing process more quickly," says Athersys Vice President of Regenerative Medicine, Dr. Robert Mays. A recent study on lab animals proved that stem cells can benefit the patients who had suffered a spinal cord injury. “The animals were able to more freely walk around their cages and had a return of bladder function," says Athersys scientist, Dr. Sarah Busch. Furthermore, they also restore the nerve cells that have died as a consequence of the injury. They can also guard the cells at the injury site from further damage by discharging protective substances such as growth factors. Lastly, they can preclude the spread of the injury that can occur after injury. We can use this new innovation to reduce the amount of people who are sitting on a wheel chair as a result of this

Unlike embryonic stem cells that are pluripotent, mesenchymal stem cells are multipotent, which means they are able to give rise to other cells, but are limited in their ability to differentiate. Though they are limited, they have “[...] demonstrated the great potential [...] for the prevention and treatment of steroid-resistant acute graft-versus-host disease (GvHD), immune-related disorders, and viral diseases” (Thanunchai, et al). Because of their great potential, MSCs can be used to treat viral diseases such as HIV. However, what comes with HIV are their side effects and the infections that it may cause. One of the most damaging effects of HIV is the risk of bone loss, osteoporosis. However “[...] PI-treated MSCs had a reduced proliferative capacity that worsened with increasing passages” (Hernandez-Vallejo, et al). Using MSCs as treatment for this risk has lowered the ability of osteoporosis to continue to grow and multiply in a patient who has HIV. Using these stem cells not only helps osteoporosis, but also organs in the body. Mesenchymal stem cells “[...] have been shown to increase intestinal barrier function, thus the transfused cells are likely to reduce microbial translocation in HIV-infected patients” (Allam, et al). MSCs has provided aid in not only treating aspects of HIV, but the conditions that may arise from it as well. They have helped patients

One day you can be diagnosed with ALS or CTE, and you feel that it wasn’t your fault because you were never informed about the causes or trained properly. Athletes should play at their own risk, but also be informed about the consequences of playing the sport which could lead to ALS, CTE, Dementia, or Alzheimer's. Sport associations should also make it safe enough to decrease their rate of getting these diseases. By adding more padding to helmets or adding and changing rules can help decrease chances. Athletes should learn how to play safe and play with good sportsmanship. If kids learn how to tackle or play with good sportsmanship can help. ALS and CTE can lead to hard life and death after being diagnosed due to the numerous injuries which lead to concussions and head trauma.

The following is a report of a subjective interview in relation to an individual living with Osteoarthritis (OA). The participant was an 80 year old female who lives independently with her husband, with symptoms mostly affecting her hands and feet, as well as previous history of knee and hip problems. The interview was conducted in a room in AD block at AUT Akoranga campus where both the participant and all three students were present. The interview was recorded and analysed using an audio recorder and written notes, with one student assuming the role of the interviewer and the others documenting the interview, all done with the consent of the participant.

Mesenchymal stem cells are attractive tools in the clinic and have been isolated from different tissues of the body but to be qualified for use in regenerative medicine, they must in addition to the characteristics described by the international society for cell therapy, be expandable ex vivo with high proliferative potentials, possess multipotent capability, and must be easy to harvest for autologous transplantation.4 The latter characteristic ensures that the donor is not subjected to extreme condition or pain in order to access their stem cell. The site for MSC isolation includes but not limited to; bone marrow, adipose tissue, whartson jelly umbilical cord, and skin.

This thesis aimed to develop culture expansion of undifferentiated human mesenchymal stem cells for potential use as autologous cell source for women for gynaecological disorders especially using small molecules, especially A83-01 (ALK 4/5/7 inhibitor). MSCs secret cytokines that act via paracrine effect to exert anti-inflammatory and immunomodulatory properties. Identification of MSCs in almost all postnatal tissues (bone marrow, adipose tissue, umbilical blood, menstrual blood, placenta and pre-/post-menopausal endometrium) have made it possible for women to choose to source MSCs from for autologous use. In addition, surface markers such as CD271, Stro-1 and SUSD2 have been identified that enrich highly clonogenic MSCs beneficial

Stem cells are homogeneous cells found in the human body which have potential to change into, or differentiate into a range of specific types of cells (Stoppler, 1996). The refurbishment and protection of many adult tissues are safeguarded by stem cells (SCs) which exist in the top of the cellular sorting section of these tissues (Beck, 2013). Practical assessments, such as transplantation, in vitro clonogenic assesses (technique used to study efficacy of exact agents in terms of the proliferation and endurance of cells) and in vivo lineage tracing, have been undertaken to evaluate the repairing and differentiation capability of normal SCs (Beck, 2013). Currently, research is on-going to resolve whether stem cell therapy is