Osteonecrosis Essay

Currently there are two main types of licensed physicians in the United States. The first is the medical doctor or the allopathic doctor. About 95% of licensed doctors have been educated at one of over 120 allopathic medical schools and have thus obtained a medical doctor degree (M.D.). The second type of doctor, the doctor of osteopathy, is less common. Osteopathic doctors make up about five percent of the physicians in the nation (Peters 730). Although this represents a significant amount of physicians many people are unfamiliar with the second type of doctor. In a 1981 the AOA (American Osteopathic Association) released the results of a survey about public

Before starting pharmacological medication preventive measures should be taken. For example, weight-bearing exercise, calcium and vitamin D intake, quit smoking and alcohol. After that start osteoporosis medication if it is primary, but if it is secondary treat the underlying cause first. These drugs do not treat osteoporosis, but decrease further loss of BMD which include Bisphosphonates (Alendronate- Risedronate- Ibandronate- Zoledronic acid), Raloxifene (Selective estrogen receptor modulators), Calcitonin (hormone decreases bone resorption by inhibiting osteoclast activity), Denosumab, Teriparatid(Parathyroid hormone). The first drug used is alendronate because of its high efficacy in preventing fractures and low cost. If the first line drug failed other bisphosnates or denosumab can be used. Ralaxofeine used as third line drug because it has a risk of developing blood clot diseases, yet it decreases the risk of breast cancer . Calcitonin is used for those who are contraindicated to the previous drugs because of its low efficacy. Teriparatid is the only drug that works by increasing BMD, but is the last drug used. It is taken for a maximum 2 years and expensive and contraindicated in those who have history or having a bone cancer. For those patients who complain of sever back pain surgery might be suitable for them as a last solution although the efficacy and safety

E. Drugs that block the effect of tumor necrosis factor have not been useful or effective for treating RA patients.

Finally, one article was found by conducting a search of the identified article’s reference section. This article was searched by title on the Cochrane database and was found useful to the clinical

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Osteopetrosis is a rare, genetic disease that causes extremely dense and brittle bones. This is because individuals affected with osteopetrosis do not have normal osteoclasts, which bones need to work correctly. Healthy bones require properly functioning osteoblasts and osteoclasts. Osteoblasts are responsible for making new bones and osteoclasts are bone cells that are responsible for bone resorption, which is the breaking down of bones and providing space for new bone marrow to grow. An individual with osteopetrosis has osteoclasts that do not function properly, therefore their bones are not healthy (Stocks, Wang, Thompson, Stocks, & Horwitz, 1998).

Osteogenesis imperfecta is a group of genetic disorders that mainly affect the bones. The term "osteogenesis imperfecta" means imperfect bone formation. People that suffer from this condition have bones that break or fracture easily; also giving it its more well-known name “brittle bone disease”. These bone fractures often occur from mild trauma or even with no apparent cause. There are eight recognized forms of osteogenesis imperfecta, they range from type I to type VIII. The types can be differentiated by their signs and symptoms, although the main characteristic features overlap between each other. Type I is the mildest form while type II is the most severe form of Osteogenesis imperfecta; the other types of this

The study was a double blind, placebo-controlled study performed between October 2002 and November 2003. The study was conducted in 53 centers throughout the United States, Mexico, South America, Europe, Asia, Australia, South Africa, and Israel. There were a total of 360 patients initially screened, however only 278 patients were included in the randomization process. The reaming 82 patients

Osteoporosis develops when the remodeling cycle, which is when the disruption of the bone resorption and bone formation occurs. The imbalance of the remodeling cycle causes osteoporosis. Hormones, cytokines, and paracrine stromal-cell interactions affect the osteoclast’s processes, which includes proliferation, maturation, fusion and activation. The osteoclasts are controlled by the interaction between several interleukins, tumor necrosis factor, transforming growth factor-beta, prostaglandin E2 and hormones. The glucocorticoid-induced osteoporosis is related to increased destruction of osteocytes. Glucocorticoid increase receptor activator of nuclear factor ligand (RANKL) effect and inhibit osteoprotegerin (OPG) production through

Fosamax is a biphosphonate that is commonly used for the prevention and treatment of osteoporosis. It would be best to take Fosamax on an empty stomach with plenty of water. Do not lie down or eat for at least 30 minutes after taking the pill. The side effects for Fosamax are abdominal pain, bone/skeletal pain, constipation, diarrhea, dyspepsia, and nausea. I would also tell M.S that osteonecrosis of the jaw may occur after dental extraction, root canal, dental implant or other oral surgeries. Lastly I would tell M.S. that oral biphosphonates are commonly associated with a serious problem called esophagitis which is inflammation of the esophagus. If chest discomfort occurs which is a symptom of esophageal irritation, she should discontinue the drug and contact her health care provider. I would assess her for poor renal function, hypocalcemia, and GERD because if she has any of these, she would not be able to take Fosamax.

The treatment of patients with mild disease consists of acid suppression (esomeprazole) and a short course of steroids (prednisolone). Those patients who have moderate to severe disease should be treated aggressively in the following way: acid suppression (esomeprazole), a longer course of steroids with prednisolone, and consideration of immunosuppressive therapy with azathioprine. Infliximab should be considered in refractory patients in order to prevent the complications of stricturing and fistula formation. Treatment with balloon dilatation of the stricture followed by injection of a long-acting steroid such as triamcinolone can also help to alleviate symptoms. Surgery may be required for severe, refractory symptoms, but it has a high morbidity

Osteoarthritis is the most common joint disorder, and more than half of all Americans who are older than 65 have been diagnosed with osteoarthritis. However, recent US data has revealed knee osteoarthritis does not discriminate age, and there is growing evidence that osteoarthritis affects individuals at a young age. The annual cost of osteoarthritis due to treatment and loss of productivity in the US is estimated to be more than 65 billion dollars.1 With no cure currently available for osteoarthritis, current treatments focus on management of symptoms. The primary goals of therapy include improved joint function, pain relief, and increased joint stability. Although the exact cause of osteoarthritis is unknown, many risk factors have been identified including increased age, female gender, obesity, and trauma.2 Within these risk factors, the etiology of osteoarthritis has been divided into anatomy, body mass, and gender.

     Osteoporosis is a health ailment which causes bones to become so porous that they can break easily. Osteoporosis literally means 'porous bones'. The bones in our skeleton are made of a thick outer shell and a strong inner mesh filled with collagen [protein], calcium salts and other minerals. The inside looks like honeycomb, with blood vessels and bone marrow in the spaces between bone. Osteoporosis occurs when the holes between bone become bigger, making it fragile and liable to break easily. Osteoporosis usually affects the whole skeleton but it most commonly causes breaks or fractures to bone in the wrist, spine and hip.

OA is a musculoskeletal disease that causes chronic joint pain and reduced physical functioning (Laba, brien, Fransen, & jan, 2013). Osteoarthritis (OA) is a non-inflammatory disorder of synovial joints that results in loss of hyaline cartilage and remodeling of surrounding bone. OA is the single most common joint disease, with an estimated prevalence of 60% in men and 70% in women later in life after the age of 65 years, affecting an estimated 40 million people in the United States (Goodman & Fuller, 2009). Women are more commonly affected after the age of 55, almost everyone has some symptoms by the age of 70 (Tan, Zahara, Colburn & Hawkins, 2013, p.78). Osteoarthritis can be described radiological, clinical, or subjective.

Vitamin intake is a commonly overlooked necessity in basic nutritional health. What most people do not know is that certain vitamin deficiencies can cause many health risks and problems. Many people believe that are getting all the vitamins they need from their diet, however most of the time they are not. One of the most common vitamin deficiencies is the low intake of Vitamin D. There are some vitamins that are produced by the body such as vitamin K; however some of the most important vitamins are not produced by the body. Vitamin D is one of the vitamins that our body needs to function correctly that is not naturally produced by the body. Vitamin D can be consumed through