Osteosarcoma Research Paper

2). In addition, this disease causes death, short stature, blindness, and hearing loss. “Seventy percent of children with malignant infantile osteoporosis die by the age of six years, and almost 100 percent do not live to the age of 10 years” (Stocks et al., p. 2). The main cause of death is bone marrow failure, due to non-functioning osteoclasts. Some children will also have delays in muscle coordination, nerve compression, low levels of iron, crossed eyes, tooth decay, abnormal hardening of the bones, and fractures. (“Osteopetrosis,” 2008).

Osteosarcoma is also called osteogenic sarcoma in medical term (“Osteosarcoma”, n.d.). This cancer usually develops in growing bones. Although it can occur at any age, it‘s most commonly found in teenagers and young adults and is slightly more common in males than females. Any bone in the body can be affected, but the most common sites are the arms or legs, particularly around the knee joint(“Osteosarcoma: An Introduction.”, 2012). This cancer is caused by benign tumors and other bone diseases, radiation exposure, genetic factors, children, adolescents, males more than females.(“Osteosarcoma: An Introduction.”, 2012)

The symptoms form Ewing’s sarcoma is pain, swelling, stiffness, or tenderness of the bone or the surrounding tissue. There may also be a lump near the surface of the skin that may feel warm and soft to the touch. The patients may also have a fever that does not go away. The sarcoma may cause weakening of the bone with the tumor, resulting in the integrity of the bone, thereby having the bone break due to a very minor injury.

Osteosarcoma(OS) is a primary malignant tumor of bone which is characterized by the formation of osteoid tissue. Although it is the most common malignancy of long bones after multiple myeloma [2], it is a relatively rarer entity in the craniofacial region. About 6% of Oss arise in the jaws .The estimated incidence of the new cases of Jaw OS (JOS) per year is 0 .07 in 100,000. (1) The etiology of OS is unknown, but some risk factors such as a previous history of ionizing radiation, alkylating agent, retinoblastoma and benign bone lesions such as paget disease and fibro osseous dysplasia have been associated with the development of head and neck OS.(2-4) JOS occur with a peak in the third through fifth decades of life. The mean age is

Osteoclasts break down bone tissue during the remodeling of bones. The malignant infantile form happens when an infant inherits a copy of the defective gene from both of the parents. For the adult form to occur, however, only one defective gene is necessary. Most of the time, however, the inherited gene is not what causes osteopetrosis. Normally the adult form is caused by a newly formed defective gene that came about at the time of

It is known to have some correlation to a tumor suppressor gene that can run in families, but is not been known to cause every case of osteogenic sarcoma. Even though healthcare professionals haven't found the direct cause there are some patients that have a better chance of developing the disease from their pre existing conditions. This disease has been known to link with familial retinoblastoma. Children that have familial retinoblastoma are more likely to develop Osteogenic sarcoma during development in their adolescent years. Before becoming very serious there are symptoms that you can notice. Some symptoms include: pain in the affected bone, limping, pain when lifting, and redness around area. Pain in the affected bone can come and go and the severity changes over time as well. Limping is caused by tumors in the legs, as the tumor grows it causes swelling and redness around area. Pain when lifting is also caused by tumors. Sometimes the first sign is a bone fracture. Some diagnostic tests include an X-ray, CT, or MRI, these tests can show the characteristics of the tumor. A biopsy can also determine what kind of tumor is causing the problems and aid in treatment. One good thing about Osteogenic sarcoma is that in most children it can be cured even though it varies between patients. Treatment usually lasts 5 to 8

Cancer affects individuals from all backgrounds, regardless of class, age, gender or ethnicity. It is known to be the leading cause of death in many countries (World Health Organization, 2013). According to the Canadian Cancer Society (2013) approximately half of all Canadians will develop cancer at some point during their lifetime. There are many different types of cancers affecting various regions of the body. A sarcoma is one classification of cancer that arises from connective tissues present in the body including bone, fat, muscles, blood vessels or the linings of joints (American Cancer Society, 2014). Rhabdomyosarcoma is defined as a cancerous tumor of undifferentiated skeletal muscle, and generally involves regions of the head and neck (Ojo, Si, Pelaez, & Younis, 2014). Rhabdomyosarcoma can be classified into three main types: embryonal, alveolar and anaplastic (Kikuchi et al., 2013). The purpose of this paper is to explore the disease process of rhabdomyosarcoma and analyze the findings relative to nursing practice.

There are 206 bones in the adult human skeleton; these bones relate to movement, posture, and protect internal organs (American society of Clinical Oncology, 2012).Bones connect to bones with ligaments and are covered and protected by cartilage (American Society of Clinical Oncology, 2012).Cancer of the bone is rare but is caused by normal bone marrow and tissues inside the bone that change and form tumors(American Society of Clinical Oncology, 2012). The tumor happens in the bone and is benign it does not spread (American Society of Clinical Oncology, 2012). The benign tumor can press against surrounding tissues and weaken the bone it it grows big enough (American Society of Clinical Oncology, 2012). Malignant bone tumors break the surrounding tissue and cortex, hard covering of the bone (American Society of Clinical Oncology, 2012). The tumor can then get into the bloodstream and spread all over the body (American Society of Clinical Oncology, 2012). Osteosarcoma and ewing sarcoma are the two most common type of bone cancer (American Society of Clinical Oncology, 2012). Chondrosarcoma is more common in adults and is cancer of the cartilage (American Society of Clinical Oncology, 2012). The last type of bone cancer is chordoma which usually starts in the lower spinal cord (American Society of Clinical Oncology, 2012). Ewing sarcoma is a type of bone cancer that affects the hip, rib, and middle of bone most often (National Cancer Institution, 2015). Ewing

An important factor when treating canine osteosarcoma is managing bone pain. Cronin (2008), a veterinary oncologist, believes pain management is challenging when treating osteosarcoma (as cited in Osborne, 2008). She mentions, “Amputation effectively relieves bone pain and is the standard of care for patients…” (as cited in Osborne, 2008). Amputation of the affected limb manages pain and improves the quality of life when combined with other treatments (as cited in Osborne, 2008). As a result, dogs are usually treated with chemotherapy (“Bone cancer in dogs”,

According to the Mayo Clinic (2013), Osteosarcoma sign and symptoms include the following: pain in and around the bone, swelling and tenderness near the affected site, broken or fractured bones, fatigue and unexplained weight loss. American Cancer Society (2014), says pain in the bone is the most common indicator. Initially, the pain is intermittent and occurs mainly at night. The pain gets worse with any physical activities. If a tumor is in the lower extremity, it may cause a limp. Edema in the region of the pain may not be prominent for a few weeks. You may be able to palpate a lump, depending on its location. Symptoms often go unnoticed in children and teens because pain or swelling in the limb is rather common in normal, active kids and adolescences. Unfortunately because of this, cancer goes undetected for a period of time. Osteosarcoma will weaken the bone in which it was formed, but the bone will not break. Most of the time, people with a fracture next to an osteosarcoma describe that the extremity was aching for a few months, but later noticed it became very painful once the fracture happened.

Osteosarcomas are primary malignant tumors of the bone characterized by the production of osteoid or immature bone by malignant cells. Although uncommon in general, they are the most common primary malignancy of bone in children and adolescents, and the fifth most common malignancy among adolescents and young adults age 15–19 years old. There is a bimodal age distribution of osteosarcoma incidence, with peaks in early adolescence and in adults over the age of 65. In children, the majority of cases are sporadic, while in older adults, about one third of the cases arise in the setting of Paget disease of the bone. Risk factors include prior irradiation or chemotherapy, Paget disease and other benign bone lesions, and inherited conditions. The majority of patients with osteosarcoma present with localized pain over several months’ duration. The pain commonly begins after an injury and may wax and wane over time. The most important finding on physical examination is a soft tissue mass, which may be large and tender to palpation. Osteosarcomas are commonly found in the metaphyseal region of the long bones, most commonly the distal femur and proximal tibia. Laboratory evaluation may find elevations in alkaline phosphatase, lactate dehydrogenase (LDH), and erythrocyte sedimentation rate. Characteristic features found on plain radiographs include destruction of the normal trabecular bone pattern, indistinct margins, and lack of endosteal bone

Most often this cancer is found at the end of the long bones of the body and usually around the knee. More often we see it in males than females (Osteosarcoma: An Introduction). Osteosarcoma goes through many stages as it progresses. Sometimes it is not always caught in the beginning stage either. It gets categorized into two groups; localized and metastatic. The first stage is localized. This is when the osteosarcoma is only seen in the bone where it started and it can also be seen in the tissues near the bone. Normally this is when the cancer is found. About 4 out of 5 patients catch the cancer at its localized stage. Localized can even be divided into two sections of its own; resectable and non-resectable. Resectable is when the tumor can be completely removed by surgery and non-resectable is when the tumor can only be partially removed through surgery. Metastatic osteosarcoma is when the cancer has visibly spread to other parts of the body. It usually spreads to the lungs, but it can also be seen to have spread to the brain, other bones, and organs. Unlike localized osteosarcoma, in metastatic only 1 out 5 of patients are seen to have their cancer spread by the time it is diagnosed. If it is not seen till this stage it is harder to treat unless it can be removed completely by surgery and chemotherapy is performed (How is osteosarcoma staged).

For this unit I chose Ewing's sarcoma, a malignant bone tumor, and a primary bone cancer that originates in bone cells. According to Derrer, David a medical reviewer for WebMD, Ewing's sarcoma is a family of tumors that is located in the long bones of the legs and arms, or bones in the chest, pelvis, back, or head (2014). It also develops in the skull or flat bones of the trunks. The most common symptoms of Ewing's sarcoma is pain, however symptoms might vary, depending on the size and location of the cancer. Other symptoms may also include swelling, tenderness, or stiffness in the affected area, fracture, fatigue, fever, weight loss, and anemia. The exact cause of Ewing sarcoma is not fully understood. There seems to be no known risk factors

There are a wide variety of cancers affecting people and their loved ones everyday such as breast, lung, brain, and skin cancer just to name a few. Bone cancer is a rare type of cancer not talked about quite as often, but it still affects a large number of people. It is important to learn about bone cancer and its many manifestations in order to make quicker diagnoses and hopefully move closer towards finding a cure.

This disease exist when cells that are forced by cancer go away from the tumor and expand to other places in the body to spread to the bones .