Our Comprehensive Synthesis Of Available Evidence Showed A Strong Association Between The Lisa And The Risk Of Late /

1389 WordsAug 17, 20166 Pages
Our comprehensive synthesis of available evidence showed a strong association between the LISA and the risk of late/very late ST and MI during the post imaging follow up. The low incidence of ST events over 18,145 person-months follow up (≈1.4% ST per person-year) in LISA group explains the limited power of previous studies evaluating this association. Our results are consistent with a prior meta-analysis of five studies which found LISA to be associated with increased risk of late ST (OR = 6.51; 95% CI 1.34-34.91)(13). We extended these findings by including 11 additional studies and longer follow up of previous studies published subsequently. Also, we accounted for variable follow up period of included studies by using person-months as offset rather than the number of patients in each group. Moreover, as recommended in literature (17-18), we used multiple statistical methods as part of our sensitivity analysis to assess the robustness of our findings. Our finding stood the test of these sensitivity analysis confirming a strong association between LISA ( and LAISA) and late/very late ST. Although we found a significant association between LISA and clinical events (ST and MI), our results do not establish a cause and effect relationship. The two cohorts, LISA and control, were unbalanced on one or more characteristics in all included studies. For instance, LISA group had longer stents and more commonly associated with acute coronary syndrome as the indication for PCI in

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