Our patient was admitted to the ICU with respiratory distress. Respiratory distress is caused by an

Type II Diabetes, also known as diabetes mellitus, is also called non-insulin-dependent diabetes or aadult onset diabetes. It is a medical disorder that, due to a number of factors codependent with the modern world, is characterized by higher than normal blood glucose levels that play havoc with insulin deficiency and resistance. Insulin resistance means that cells do not respond appropriately when there is free insulin in the blood system. Essentially, they body is reacting to an improper balance of sugars and insulin. Because obesity is often present, research suggests that even thought the mechanisms controling glucose and insulin are unclear, the adopose tissue likely

Type 2 Diabetes effects about 90% of people who have diabetes. Ways of controlling this type is by losing weight, having a healthy diet, plenty of exercise, and monitoring their blood-glucose levels. Although people people do these things to help, Type 2 is usually a progresses disease where is gets worse, and causes the person to have to take insulin usually in the form of a tablet. People who are overweight and obese have a significantly higher risk of developing Type 2 Diabetes as apposed to those who are at a healthy body weight. Those that are especially at risk are those who have visceral fat, which is also known as central obesity, belly fat, or abdominal obesity. Being overweight of physically inactive along side with eating the wrong foods all increase the risk of developing Type 2 Diabetes. The risk also rises with our age, because as we age we tend to become less active as well as gain weight. When men have low levels of testosterone levels they also get placed at a higher

Diabetes occur when there is a combination of inadequate secretion of insulin by the pancreatic beta cells and the peripheral insulin resistance. Insulin resistance leads to a reduced glucose transport into the muscle cells, increases both hepatic glucose production and breaking down of fats because it has been attributed to the elevated level of free fatty acids and proinflamatory cytokines in the plasma.1

Insulin resistance is the first physiological change occurring in type two diabetes. In these type two diabetic patients, insulin is unable to move glucose into liver, kidney and muscle cells although insulin is able to attach properly to the cell surface receptors. In order to rectify this, most patients with type two diabetes start secreting normal to very high levels of insulin, which can initially overcome this resistance. After a while, the pancreas cannot keep up with this high insulin production and the cells become resistant to glucose intake. Persistent hyperglycemia or high blood glucose levels are not desirable since this causes damage to the beta cells of the pancreas that produces the insulin hormone. This damage to beta cells further hampers insulin synthesis and patients at this stage are categorized as full-blown diabetic. Such patients consistently show a hyperglycemia state even after hours of fasting ( Hinkle & Cheever,

Diabetes Mellitus (DM) or Type 2 Diabetes is seen as a metabolic disease that is categorized by abnormally high blood glucose or hyperglycemia. Diabetes Mellitus is also formerly known as noninsulin-dependent diabetes mellitus and is the most common form of diabetes that is seen. Insulin is a hormone that is supplied to the body that allows us to efficiently use glucose as fuel. When carbohydrates are broken down into sugars in the stomach glucose enters the blood circulation simulating the pancreas to release insulin in an appropriate amount to become used for energy. With diabetes mellitus the body does not properly make use of the insulin supplied for the body. This causes the pancreas to produced an extra amount if insulin which the body cannot keep up with, causing an imbalance to the blood glucose levels (American Diabetes Association, 2015). In the united states diabetes affects almost 29.1 million people, while the another 86 million people have pre-diabetes but do not know. It is also known as the 7th leading cause of death in the country in the recent years (MedicineNet.com, 2016). For a patient suffering from a chronic form of diabetes mellitus understanding how these mechanisms lead to the condition can be used as preventative measures. Potential consequences as well as the causes and clinical manifestations will ensure a better knowledge on the issue to monitor the condition.

He said, diabetes mellitus is a chronic disease that occurs when the body doesn 't make enough of insulin, or the body doesn 't use insulin properly. Insulin is a key to regulation of blood glucose in our body. In types II diabetes a condition of when insulin insensitivity as a result of insulin resistance that decreases insulin production and eventual pancreatic beta-cell failure enough insulin to meet body needs. Impairment of beta- cell also can lead to problems with insulin production and resistance that can interfere with the process of glucose uptake in by cells and muscle. This condition leads to a decrease in glucose transport into the liver, muscle cells, and fat cells which can lead to a condition called hyperglycemia. Hyperglycemia occurs when there is a high level of blood glucose levels in our blood (Concepts Advisory Panel (2015) p.742).

Diabetes mellitus type 2 is an endocrine disorder that causes impaired use of carbohydrates while enhancing the use of proteins and lipids. This is called insulin resistance, in which the pancreas cannot make enough insulin to keep blood glucose levels normal, or the body is unable to use what is produced. The impairment causes blood glucose level to rise higher than normal. There is no cure for type 2 diabetes mellitus and it is life threatening when left untreated. Signs and symptoms of this disorder include vision changes, increased thirst, increased hunger, increased frequency of urination, stomach pain, nausea and vomiting, erectile dysfunction, and absences of mentruation. These can occur abruptly, or over a long period of time.

38. American Journal of Respiratory care and critical care Medicine, Volume 175, issue 7, pages 698 – 704

Diabetes has become a widespread epidemic, primarily because of the increasing prevalence and incidence of type 2 diabetes. Diabetes is an endocrine disease in which the body has either a shortage of insulin or a decrease ability to use insulin or both. Insulin is a hormone that allows glucose to enter the cells and be converted into energy. Diabetes can be characterized as a prevailing, incapacitating, and deadly disease. There are a number of risk factors that increase a person’s tendency toward developing type II diabetes. Modifiable risk factors include obesity, physical inactivity and poor dietary habits are just a few. The

In type 2 diabetes a person’s body produces insulin, but the pancreas does not produce enough insulin to maintain bodily functions or the body cannot use the insulin the way it is supposed to. When the body is unable to use insulin properly it is known as insulin resistance. “When there isn’t enough insulin or the insulin is not used as it should be, glucose (sugar) can’t get into the body’s cells” (WebMD, n.d.). When this happens glucose builds up in the blood and is not absorbed by the cells, which causes the body to not function properly. Some of the subsequent damage that can develop as a result of this

According to the American Lung Association, “Acute respiratory distress syndrome (ARDS) is a rapidly progressive disease occurring in critically ill patients.” ARDS is an extreme manifestation of a lung injury that can be associated with an acute medical problem. This occurs as a result of direct or indirect trauma to the lungs. With nearly 200,000 cases in the United States each year, ARDS is not extremely common (“Acute Respiratory Distress Syndrome”). Most people who acquire this disease are critically ill patients within the hospital. The most common predisposing medical problems of ARDS consist of: shock, trauma, pulmonary infections, sepsis, aspiration, and cardiopulmonary bypass (Ignatavicious, 2013). ARDS is a severe syndrome and even with prompt and aggressive medical treatment, almost fifty percent of those diagnosed do not survive. Those who survive have a longer hospital stay along with recurring hospital admissions throughout their lifetime (“Acute Respiratory Distress Syndrome”). Acute respiratory distress syndrome is a rapidly progressive disease which requires thorough assessment, rapid diagnosis, and emergency treatment measures in order to successfully respond to the disease process.

The organs involved include the liver, muscle, fat cells, liver, alpha and beta cells of the pancreas, GI tract, kidney, and brain. While the liver and muscle ideally increase glucose uptake in the fed state when insulin levels are high, with type 2 diabetes this is impaired. To further exacerbate the hyperglycemic condition, the liver not only fails to properly exhibit glucose uptake, but it actually over produces more glucose and thereby creates a cycle of glucose accumulation and further production. While this is occurring in the muscle and liver, fat cells have accelerated lipolysis. The lipolysis results in an increase in plasma free fatty acids (FFAs), which then in-turn impairs both first and second phase insulin secretion and can lead to excess fat deposition in the liver and muscle, contributing further to impaired insulin production. At the GI tract, gastric inhibitory polypeptide becomes resistant and loss of GLP-1 occurs. With impaired GLP-1, insulin resistance is again further enabled and hyperglycemia can become more profound. This occurs because glucagon suppression from the pancreatic alpha cells post meal does not occur as it would under normal circumstances, thereby enabling even more hepatic glucose production. While theories are not completely conclusive, insulin resistance in the hypothalamus may contribute to excess intake thereby contributing to additional glucose in the circulation. Finally, the kidney also plays a role in glucose dysregulation as it increases glucose reabsorption. All of these discussed mechanisms ultimately contribute to hyperglycemia and chronic hyperglycemia itself contributes to impaired beta cell function (DeFronzo,

The condition is characterized by reduced secretion of insulin and insulin resistance in the body which leads to increased demand for insulin in the body. Consequently, the pancreatic B-cell is unable to meet the need for insulin which leads to an upsurge in blood glucose level. The disease causes eventual failure of body organs including eyes, nerves, kidneys, heart and blood vessels which will ultimately cause death. Poor lifestyle which comprises poor diet and reduced exercise is the primary cause of type 2 diabetes. Type 2 diabetes has become one of the leading killer diseases and is rapidly growing thus raising concern (Sherwin,

Type 2 diabetes is a chronic disorder in which the body does not properly respond to insulin well, thus allowing high concentrations of glucose to

Destruction of beta cells > Beta cells decline> insulin secretion decreases until insulin is no longer available to maintain normal blood glucose levels.>Beta cells