Ovarian Cancer Case Study

An abnormality in this process leads to a number of problems, including cancer. MicroRNAs are a type of RNA which inhibit the expression of genes and play a vital role in the development of cancer. Of notable interest is miR-378, as it increases tumor angiogenesis and growth and also enhances the survival of these cells, by decreasing the expression of tumor suppression genes like Sufu. A study testing human cell lines found that when Sufu expression levels were high, miR-378 expression levels were low, and when Sufu levels were low, miR-378 levels were high, showcasing that the two were negatively correlated. Because repression of Sufu can lead to rampant proliferation of cells, the inhibition of Sufu is essential in order for miR-378 to promote angiogenesis and increase cell

Ovarian cancer is a lethal gynecological malignancy; although median age of diagnosis is 56 and older (post-menopausal) it can affect women of any child-birthing age. It is the 5th most common cancer diagnosed in the UK with 7,284 new cases in 2013 (Ovarian Cancer Statistics, 2013) Although the incidence is less than that of breast cancer, there is a greater number of deaths (4,271 deaths) associated with it. Almost three-quarters of the ovarian cancer are diagnosed at late stages after tumors have metastasized within the peritoneal cavity.

Ovarian cancer is cancer that begins in the ovaries. Ovaries are reproductive glands establish only in women. The ovaries produce eggs (ova) for reproduction. The eggs journey during the fallopian tubes into the uterus where the fertilized egg embeds and establish into a fetus. The ovaries are also the major cause of the female hormones estrogen and progesterone. One ovary is situated on each side of the uterus in the pelvis. Many types of tumors can generate rising in the ovaries. The majority of these are benign (noncancerous) and never multiply outside the ovary. Benign tumors can be treated effectively by removing either the ovary or the part of the ovary that contains the tumor. Ovarian tumors that are not benign or malignant (cancerous)

MiR-21 has been found to be over expressed in 20 pancreatic carcinoma tissues and cell lines compared to normal tissue or cell lines. (15)

Epithelial tumors about ninety percent of ovarian cancer develop in the epithelium, which is the thin sheet of tissue that protects the ovaries. This form of ovarian cancer generally occurs in postmenopausal women. Germ cell carcinoma, making up about five percent of ovarian cancer causes, begins in the cells that form eggs. Germ cell carcinoma can transpire in any woman; however, it tends to be found in women who are just entering adulthood. There are several different varieties of germ cell carcinoma that exist, but the three most familiar types are teratomas, dysgerminomas and endodermal sinus tumors. Most of the tumors that surface in the germ cells are not cancerous. However, stromal carcinoma tumors ovarian stromal carcinoma are malignant, accounting for about five percent of ovarian cancer cases. These tumors emerge in the connective tissue cells that connect the ovaries together and those that produce female hormones such as estrogen and progesterone. The two most common types of tumors are granulosa cell tumors and sertoli leydig cell tumors. In contrast to epithelial ovarian carcinoma, 70 percent of stromal carcinoma cases are detected when they are in the beginning stage. Small cell carcinoma of the ovaries is a rare, distinctly c tumor that affects primarily young women whom have an average age of 24 years old. The subtypes of small cell carcinoma of the ovaries includes pulmonary, neuro-endocrine and hypercalcemic small cell carcinoma of the ovaries accounts for 0.1 percent of ovarian cancer instances. Approximately two thirds of patients with small cell carcinoma ovaries have hypercalcemia which is when there is an abundant amount of calcium in the blood. (``Types of Ovarian Cancer``,

Ovarian cancer is cancer of the ovaries and is listed as the fifth cause of death in women. Ovaries are the reproductive glands of only females and the main source of a female’s estrogen and progesterone. The ovaries are made up of 3 kinds of cells, which can also develop different types of tumors. Epithelial tumors start from the cell that covers the outer surface of the ovaries. Germ cell tumors start from the cells that produce the eggs. Stromal tumors start from the structural tissues that hold the ovary together and produce the female hormones (1).

I am writing about Ovarian Cancer it is a terrible disease that can be extremely deadly. It is a disease in which your cells start to become abnormal and grow out of control and uncontrollably. Ninety percent of all ovarian cancer develops in the cells that line the ovaries and are called epithelial cell tumors.

This paper will explain what every woman, teenager, and parent who has female daughter’s needs to know about endometrial cancer. It is important for women to educate themselves about this common disease, but it is also important for parents. If you have abnormal vaginal bleeding that is not related to menses, there is a clear vaginal discharge, you have long and / or heavy bleeding after the age of 40, difficult or painful urination, pain in the pelvic area, or if you feel any kind of pain after intercourse, that it is

Ovarian cancer is the abnormal growth of malignant cells in the ovaries, the egg (ovum) producing part of the female reproductive system. Often, Ovarian cancer goes undetected until it has metastasized (spread) to the pelvis and abdomen. At this late stage, this cancer is difficult to treat. Ovarian Cancer ranks as the 11th most common cancer among women, and it is the 5th leading cause of cancer-related death for women.

According to lead nurse Carolyn Rooth, the majority of ovarian malignancies (approximately 50-60%) are serous carcinomas with epithelial origins (S24). Benign epithelial ovarian tumors do not spread and for the most part do not lead to serious illness. LMP or low malignant potential tumors can be viewed under the microscope can show that they are not cancerous. These borderline cancers are unlike typical ovarian cancers because they do not branch out into the ovarian stroma, also known as supporting tissues (Wolfe). Epithelial tumors that are known to be cancerous are malignant tumors.

Ovarian cancer is the fifth most common cause of death for women in the United States. In 2017, it's estimated that less than 40% of women who are affected by the disease will achieve a successful cure. Some women with the difficult-to-treat disease often have tumors that are not only at advanced stages but also able to resist current chemotherapy drugs.

Ovarian cancer is less common, with a projected 22, 440 new cases. However, it carries a much higher mortality rate.

Ovarian cancer is a type of cancer related to the ovaries. It currently accounts for approximately 3% of all cancers in women. Ovaries are comprised of three types of cells, each of them being able to differentiate into a type of cancer. These three types are epithelial, germ, and stromal cells. The most common type of ovarian cancer is derived from the epithelial cells. According to the American Cancer Society, ovarian cancer is the leading cause of death from all types of cancer that are related to the female reproductive system. Moreover, it is estimated that approximately 55% of women diagnosed with ovarian cancer die in the first 5 years of diagnosis. However, if the tumor is diagnosed before the age of 65, this percentage decreases.

Gynecological cancers continue to be an important health problem worldwide.[1] Gynecological cancers accounts for 1/3 of entire female malignancies. [2] Cervical, endometrial and ovarian cancers are the leading types of gynecologic cancers. While Vulval, vagina, fallopian tubes and choriocarcinoma are less frequent sites for female genital malignancies. [3] Worldwide incidence and mortality rates (per 100.000) of gynecological cancers are respectively as follows: cervical cancer 16.1 and 7.99, endometrial cancer6.4 and 1.5, ovary and other gynecological cancers 6.5 and 3.8. [2]

This is the first study of its kind, with a comprehensive analysis of the prognostic effects of miRNA in stage II colorectal cancer in the form of a systematic review and meta-analysis.