Overview Of Embryonic Stem Cells

Embryonic cells should be allowed to be used because of the medical benefits they provide. They can be used to cure diseases such as Parkinson’s disease, diabetes, traumatic spinal cord injury, Duchenne’s muscular dystrophy, heart disease, and even vision and hearing loss (nih.gov 2009). There is no problem using them for medical purposes and it is not immoral to use them for this reason. Embryonic cells have the potential to save lives. Therefore, the usage of embryonic cells outweighs the ethical issues.

Pluripotent stem cells are the stem cells that can only differentiate into a limited range of differentiated cells. (2) They have the ability to give rise to all somatic cells from ectoderm, mesoderm and endoderm, as well as gametes. Naturally it can be found in embryos as Embryonic stem cells (ES cells). Induced pluripotent stem cells (iPS cells or iPSC) are the pluripotent stem cells that are generated directly from adult cells, first discovered by Shinya Yamanaka in 2006 by using a set of reprogramming factors (Oct4, Sox2, Klf4, and c-Myc or LIN28 and Nanog) (3) to reprogram mature cells back to a pluripotent state (4).

Millions of people die every year from diseases, accidents, and defects, one only needs to turn on the nightly news to hear of the devastating effects of cancer or of horrific accidents that have left people disfigured or paralyzed. Stem cell research is a part of biomedical science that has the potential to cure diseases and defects, create organs for patients needing transplants, regenerate axons in spinal cord injuries, and create new treatments, drugs, and immunizations. However, federal funding is limited and does not cover embryonic stem cell research to an extent that would make a difference in medicine. The United States should support embryonic stem cell research by increasing federal funding, opening new stem cell lines for

Christopher Reeve, better known as superman, was not only an actor, but also an athlete and an adventurer. On two separate occasions, he flew an airplane sole across the Atlantic Ocean. On Memorial Day weekend in 1995, Chris rode his horse, Buck, to the starting box of a cross-country race in Virginia. Chris had trained and raced horses for almost ten years, so he felt the course ahead of him would be easy. But what Chris did not see coming was just as he and Buck approached the third jump, Buck would come to a sudden stop, sending Chris over the jump. He landed directing on his head, fracturing two vertebrae in his neck. From that day on, he was completely paralyzed. At the time, there was no known treatment, no medication, and no surgery to fix his damaged spine. For the rest of his days, Chris raised money and awareness for research into spinal cord injuries. One of the topics he pushed for was embryonic stem cell research. Christopher Reeve died on October 10th, 2004, never fulfilling his goal to walk again. But if he had gotten the support and funding for stem cell research, his story might have ended differently. Embryonic stem cell research should be funded in the U.S because it could lead to the treatment to many diseases, there are other sources of stem cells, but they are limited to their use, and the eight-celled blastocysts cannot grow any further to form a baby, so it is not harming living human beings.

Embryonic stem cells are found in human blastocysts (Marcovitz 17). A blastocyst is a very young embryo (just a few days old) that contains around 200 undifferentiated stem cells (Marcovitz 17). German Zoologist Valentin Hacker coined the term “stem cell” after he discovered them in a blastocyst of a crustacean (Marcovitz 18). Embryonic stem cells were collected for the first time in 1988 by Dr. James Thomson of University of Wisconsin and by Dr. John Gearheart of Johns Hopkins (Panno 76). These stem cells are unspecialized; they do not perform a specific function like cells such as muscle and nerve do (“Stem Cells”). They are also pluripotent, meaning they have the ability to divide and become specialized cells (“Stem Cells”). This is why stem cells hold so

Embryonic stem cells have the ability to grow into any type of cell that your body contains and can potentially aid in curing diseases and or repair many essential things in your body such as a kidney or a lung. This sounds like an extremely favorable advantage to medical advancements but this subject does summon some intense debates on where the stem cells come from. Embryonic meaning that it comes from the embryo veers many people’s opinion to totally protest any use of embryonic stem cells. Opposing abortions and the use of embryonic stem cells go hand in hand. Many people are just not ready for the responsibility of having a child so they take matters into their own hands and many consider having an abortion. In the end everyone takes their own decision and they fit it to what they feel is best for their lives. Many people may see an abortion as killing an innocent life but people make their own decisions and no one can stop them. Abortions are a solution to unprepared individuals that can not handle the responsibility of having a child; why not use the cells from the procedure to save a life. Children are wonderful gifts but some people are just not ready to take up the responsibility of raising that gift so they can use that gift to help another needy life.

Embryonic stem cells (ESCs) are grown in the laboratory from cells found in the early embryo. ESCs have an unlimited chance to

What is Embryonic? Embryonic is relating to an embryo, or an unborn. Embryonic stem cell research is a theory by scientists, that research can cure painful diseases such as Diabetes, Parkinson’s disease, Cancer, Heart Disease, and many other unusual genetic disorders. The Embryonic stem cell research began in 1988 by James Thomson and his associates. James Thomson discovered how to excoriate the human embryonic stem cells from within the cell mass through IVF, given for research intendment. IVF is the act of removing fertile eggs from a female’s ovaries and fertilized with sperm in a laboratory culture dish.

As technology advances, the use of embryonic stem cell research has also expanded. Stem cells have shown promise in personalized medicine as they are undifferentiated and easily conform with the surrounding cells. There are two areas of research that stem cells are showing massive potential, cell regeneration and organ transplantation. It is thought that stem cells have the capability to “model genetic disorders in a reliable fashion such that no other method allows. It seems likely that we could use stem cells to model cells with genetic disorders and figure out how to mute certain genes, thus eliminating or drastically reducing the effects of the disease,” (1). Although embryonic stem cells (ESC) are showing great potential towards medical advancements, there are many people who are opposed to the idea of using these cells due to the aggressive nature in which we extract ESC.

The ability to manipulate the stem cell corresponding to a specific organ/tissue remains important. A type of stem cell that can be manipulated is the embryonic stem cell. These stem cells descend from embryos aging from three to five days (Watt) (Driskell). During earlier stages, scientists describe embryonic stem cells as “blastocysts” which contain over one-hundred and fifty cells (Watt) (Driskell). They duplicate into more cells or transform to any cell located in the body (Watt) (Driskell). This “duplication” allows embryonic stem cells to regenerate and repair diseased tissues. Embryonic stem cells gain importance in cancer treatments—if doctors diagnose patients with leukemia, then during chemotherapy, the doctor can infuse embryonic stem cells into the body. Since the cells are young, they can repair the targeted cell, aiding cancer treatments and the patient. In addition, this technique is used with another type of embryonic stem cell called “pluripotent stem cells”. Pluripotent stem cells originate as inner mast cells (cells

“Over 100 million Americans suffer from diseases that eventually may be treated more effectively or even cured with embryonic stem cell therapy. Some researchers regard this as the greatest potential for the alleviation of human suffering since the advent of antibiotics” (White). However, not everybody agrees with this. While embryonic stem cells offer much hope for medical advancement because of their ability to grow into almost any kind of cell, the moral debate of the destruction of an embryo continues. Embryonic stem cells are taken directly from an embryo before the embryo 's cells begin to develop into their specific cells. While there may be promise of embryonic stem cells triggering medical advancements, the ongoing controversy continues to hinder research.

While embryonic stem cells can restore and repair tissue, there also can be a risk when inducing them into

“Through the isolation and manipulation of cells, scientists are finding ways to identify young, regenerating ones that can be used to replace damaged of dead cells in diseased organs. This therapy is similar to the process of organ transplant, only the treatment consists of the transplantation of cells rather than organs. The cells that have shown by far the most promise of supplying diseased organs with healthy cells are called stem cells.” (Chapter Preface)

iPSCs are adult stem cells that have been genetically reprogrammed to behave like the pluripotent stem cells found in embryos, i.e. can differentiate into any cell type in the human body. This was first completed successfully in mice in 2006 by Shinya Yamanaka and his team (Takahashi et al., 2006), then in humans in 2007 both by Yamanaka (Takahashi et al., 2007), and by James Thomson and his team in America independently (Yu, et al., 2007). Yamanaka and Thomson’s methods were similar. In the report by Yu et

Stem cells in fast emerging scenario act as the best biotechnological application in both therapeutic and cellular therapeutics. With recent advancement in medical and genetic manipulations, its profound applicability in novel therapeutics have put a question its efficiency as a cell based product and of intellectual property rights and technology transfer. In recent times, academic Institutes and Corporations account to over 85% of both published patent applications and granted stem cell patents where corporation are in the priority list. (www.ipo.gov.uk/informatic-stemcells.pdf or report from UK IPO Patent Informatics Team, June 2012). Analysis of published patent applications suggest recent research to be mainly focused on mesenchymal stem cells, embryonic stem cells and artificially induced pluripotent cells where, ESCs, hematopoietic stem cells (HSCs) and neural stem cells (NSCs) appear to be successfully used respectively in cardiovascular disease, diabetes, neurological disease and tissue and organ stem cell therapy.