Overview of Genetic Ailments in the UAE

The P1 cross was between four wmf females and nine wild-type males. The F1 progeny consisted of 12 wild-type females, and four triple-mutant males. The P2 cross resulted in 13 females, and 3 males, all with the wild-type phenotype (Table 1). The two parental crosses identify that the mutations are X-link recessive. The triple-mutant females of the P1 cross produce mutant male offspring, but wild-type females. The F1 females would be heterozygous for the mutations, but don’t express the mutations because they still have a wild-type X chromosome. However, the F1 males only have one X chromosome that comes from a mutant mother. The offspring for P1 were crossed again to make and F1 cross. The F1 cross would be X+/Y and X+/X. The F1 cross resulted in 100 F2 progenies over the course of 7 days.

Cystic Fibrosis (CF) is the most common and fatal genetic disease currently in the United States, affecting roughly 30,000 Americans each year (National Human Genome Research Institute, 2013). CF is an autosomal inherited disease that adversely affects the mucus and it’s production throughout the entire body. Mucus is normally a slippery substance that lubricates and protects vital organs and body systems including the lining of airways, reproductive system and digestive systems. Patients who are diagnosed with CF actually have mucus that is abnormally sticky and thick, which places them at a high risk for severe pulmonary, digestive, and reproductive problems. Specifically regarding the pulmonary system CF patients often develop clogged airways, leading to bacterial infections and breathing abnormalities such as chronic coughing, wheezing, inflammation and lung damage. As a result of this recurrent and problematic, this places the patient at an increased risk for permanent lung damage and disease. Over time due to recurrent, chronic lung infections the characteristic of the lungs begin to change as more and more scar tissue develop making them fibrotic and develop cysts.

The reading shows disease and inheritance in an entirely new light. It introduces the idea that genetically inherited diseases may have been selected for, which means that they must provide certain evolutionary advantages. It reorients the reader’s perspective about a disease like hemochromatosis, which has the potential to be incredibly harmful and even deadly, establishing that it may have once provided protection from the bubonic plague, making it an advantageous trait. This brings other genetic diseases into question, examining why diseases that appear to be harmful have not been eliminated from the gene pool. The idea that a disease that is harmful and dangerous in modern times could have once been a beneficial adaptation is very interesting.

Genetic disorder is a disease that caused by an abnormality in an individual’s DNA. Genetically inherited disorders has only been discovered within the past 150 years. The Incidence of new disorders in our society has led to change into societal attitudes to disease. Some disorders that affect multiple family members are caused by gene mutations (one or more genes) which can be inherited. There also other conditions that appear to run in families that are not caused by mutations. Which instead, environmental factors such as dietary habits or a combination of genetic and environmental factors that are responsible. Passing on mutations are known as monogenic conditions. Monogenic conditions can be inherited in three main ways; autosomal recessive

Of that number, only 15 percent of the population are nationals. They have a migration rate of 21 percent, which is higher than any other country. The religion in the UAE is 80 percent Muslim with a high concentration of Sunni and Shi’a fanatics, 100 percent of the native born Emirates are Muslim. “The UAE is an Arab country, a state member of the League of Arab States and a member of the Gulf Co-operation Council (GCC). This council includes Bahrain, Kuwait, Oman, Qatar and Saudi Arabia. Arabic is the official language used.” (“5 Cultural Facts,” 2014)

Excellent discussion especially you mentioned about “the American Society of Human Genetics (ASHG) published its policy statement on professional disclosure of familial genetic information”. I agree with you. There is no breach of confidentiality when the life of someone is at risk. There are cases Law about it in California, Florida, and other states in United States. I just quote these cases as an example; however, there are three specific situations when the healthcare provider has a legal duty to intervene and warn a person at risk.

It has long been known that heredity affects health; therefore, genetic disorders do so. Genetic disorders are diseases caused by mutations or abnormalities of genes. Genetic disorders are still viewed as an uncommon event in our world. However, it is revealed that every year, an estimated 7.9 million children, 6 percent of total births worldwide, are born with a serious birth defect of genetic origin. The Middle Easterners, comprising approximately of 400 million individuals, share many similar characteristics with important influence on their genes. Middle Easterners suffer from one of the highest rates of genetic disorders in the world. Over the last decades, the number of genetic disorders in the Middle East had increased significantly

In conclusion, genetic disorders are diseases that are caused genetic mutations. The increase of genetic disorders in the Middle East contributes to the fact that the rates of inbreeding are often high, high maternal age, and the increase of the marriage of carriers. Genetic disorders do not only affect the patient physically, but it can also affect psychologically. Schools and the media should be used to improve understanding of genetic diseases among health professionals and the public to raise awareness and educate people about genetic disorders. In addition, pre-marital screening must be obligatory to direct the Middle East towards a healthy society that is free of genetic disorders.

Genetic disorders have plagued people for ages. However, recent research and new discoveries in gene therapy has brought new hope to those unfortunate individuals that are ailed by their own genetics. Gene therapy is a technique of correcting defective gene sequences specifically responsible for the disease. In 1990, the first successful clinical trial of gene therapy was initiated for adenosine deaminase deficiency (GT). Since then, the number of clinical treatments induced worldwide has increased exponentially. Gene therapies have been a part of modern medicine for almost two decades now. Only recently have scientists started to deliver on their immense promise after a string of setbacks raised doubts about the safety of manipulating human DNA. The idea of gene therapy has been around for a while, but it wasn’t until recently that this field of molecular biology has come more into the light with its advancements over time. Experimentation has been an ongoing process with gene therapy. Although, ethical issues of controversy have surrounded this topic since the beginning. But new facts on gene therapy continues to rebuttal most controversy.

Derived from the name Albus, which in Latin means “white”, Albinism is defined as a genetic condition/disorder in which the sufferer lacks pigmentation in their eyes (ocular albinism) and/or skin (oculocutaneous albinism). Typically, Albinism is inherited when the sufferer obtains a gene from both parents, a single exception is present in the form of ocular albinism, which only requires a mother to pass the gene down. Someone with a complete loss of all pigment is called an albino, but if the sufferer still has some pigmentation, they are then considered Albinoid or leucistic. Albinism is considered rare (with less than 200,000) in America, but is very common in Africa, having 1 in every 1500 births.

There are many genetic diseases and disorders in the world these days, some of which are stranger or more unique then others. One such unique genetic disease is Congenital Insensitivity to Pain with Anhidrosis or CIPA for short. This particular genetic disease causes people who have to it to not be able to feel pain or even differentiated between hot or cold. As well as be unable to sweat, because of the anhidrosis. This genetic condition is also known as hereditary sensory and autonomic neuropathy type IV, but in this paper it will only be referred to as CIPA.

Many people every year find out that they have some sort of genetic disease. Genetic diseases affect an estimated 12 million people and their families. According to Mayo Clinic Staff: Albinism, among all the genetic diseases one of the most uncommon is Albinism, which has less than 20,000 cases in the U.S. per year. Albinism is an inherited disorder that produces little or no pigment due to no melanin. This is one of the genetic diseases that can be self diagnosed although, there are tests available for a professional to diagnose for further precaution. Albinism is a disease that can last for years (which is very rare) or a life time because there is ultimately no cure. Albinism is a very rare disorder that

There are three categories that can classify genetic diseases. They are single gene disorders, chromosome disorders, and multifactorial disorder or complex disease. Each of these categories are different with and affect people in certain ways. Single gene disorders, also called Mendelian disorders, are caused by a modification that occurs in one specific gene. An autosomal dominant defect occurs when there is an altered gene and a healthy gene that are inherited. An example of this type of defect would be Huntington’s disease, an individual only needs one copy of this defective gene on chromosome four to have the disorder. Autosomal recessive defect, is another type of single gene disorders that occurs when there is two altered variations of

The United Arab Emirates (U.A.E) is a federation of seven Emirates that was formed on December 2 1971. It is located between the Arabian Gulf and the Gulf of Oman and it is bordered by Saudi Arabia and Oman. The country has a total population of 3,740,000 as of 2004. Approximately 85% of those resideing the in UAE are not native to the country. Arabic is the official language,

UAE is located at the southeast end of the Arabian Peninsula on the Arabian Gulf sometimes referred to as Persian Gulf, bordering Oman , and Saudi Arabia to the south, sharing sea borders with Qatar and Iran (CIA World Factbook). The population is estimated to be 9.446 million and consists of 1.4 million Emirati citizens and 7.8 million expatriates, majority of whom came from India, Pakistan, Philippines and other Arab countries. It was established in 1971 as a federation of seven emirates (states). Each emirate is governed by a monarch; together, along with some elected representatives, they form the Federal Supreme Council – legislative organ. One of the monarchs is selected as the President of the United Arab Emirates.