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Oxazepam Research Paper

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Oxazepam
It is the prototype of (3-OH) of 1, 4 benzodiazepine-2-one

Chemical structure :

IUPAC Name :
7-Chloro- 3-hydroxy- 5-phenyl- 1,3-dihydro-1,4- benzodiazepine -2-one.
Uses:
Oxazepam is used
1-for reducing the nervous tension
2- for treating anxiety
3- for treating alcohol withdrawal
4- For treating anxiety associated with depression
5-for treating social phobia
6-for treating post traumatic disorder
7- for treating insomnia

Side effects:
Less serious side effect including headache, drowsiness, vomiting, nausea, dizziness and constipation.
Serious side effect including confusion, hallucination, decreased inhibitions and no fear of danger.
Mechanism of action:

Oxazepam has an anxiolytic effect as it potentiates the effect of GABA by acting on GABA receptors. …show more content…

Metabolism:
Oxazepam has short duration and rapid conjugation with glucouronic acid than diazepam or nordazepam.
3-OH make it more polar so it has rapid conjugation and less accumulation in the body
** oxazepam can be used for patients with liver dysfunction as it has low accumulation level in the body so will cause less adverse reaction.
** In neonates, oxazepam storage occurs in some organs like heart so they will have high risk of accumulation.
**During pregnancy and breast feeding, the oxazepam is exerted in breast milk.

Dosage form:
Oxazepam presents in the market as form of tablets or capsule in concentration ranging from 10 to 15 to 30 mg.

*Conclusion part
Oxazepam is safer than other benzodiazepine.
Oxazepam has short duration and rapid conjugation with glucouronic acid than diazepam or nordazepam.
3-OH make it more polar so it has rapid conjugation and less accumulation in the

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